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Full name:: anti-Inositol Polyphosphate Phosphatase-Like 1 Anticorps (INPPL1)

Chez www.anticorps-enligne.fr sont 91 Inositol Polyphosphate Phosphatase-Like 1 (INPPL1) Anticorps de 16 de différents fournisseurs disponibles. De plus, nous expédions Inositol Polyphosphate Phosphatase-Like 1 Kits (6) et Inositol Polyphosphate Phosphatase-Like 1 Protéines (3) et beaucoup plus de produits pour cette protéine. Un total de 106 Inositol Polyphosphate Phosphatase-Like 1 produits sont actuellement listés.

Synonymes:: 51C, INPPL1, OPSMD, Ship2, si:bz46j2.7, si:rp71-46j2.7

afficher tous les anticorps	Gène	GeneID	UniProt
	INPPL1	3636	O15357
	INPPL1	16332	Q6P549
	INPPL1	65038	Q9WVR3
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Human Polyclonal INPPL1 Primary Antibody pour ICC, IF - ABIN151139 : Yoshinaga, Ohkubo, Sasaki, Nuriya, Ogawa, Yasui, Tabata, Nakajima: A phosphatidylinositol lipids system, lamellipodin, and Ena/VASP regulate dynamic morphology of multipolar migrating cells in the developing cerebral cortex. dans The Journal of neuroscience : the official journal of the Society for Neuroscience 2012 (PubMed)

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Zebrafish Inositol Polyphosphate Phosphatase-Like 1 (INPPL1) interaction partners

Human Inositol Polyphosphate Phosphatase-Like 1 (INPPL1) interaction partners

The authors report two novel mutations in the INPPL1 gene and show that cell migration is very much decreased in fibroblasts derived from three opsismodysplasia (OPS (Montrer LRP5 Anticorps)) patients as compared with control individuals. In contrast, cell adhesion on fibronectin (Montrer FN1 Anticorps) is increased in OPS (Montrer LRP5 Anticorps) fibroblasts.
Aiming to uncover interdomain regulatory mechanisms in SHIP2, the authors determined crystal structures containing the 5-phosphatase and a proximal region adopting a C2 fold. This reveals an extensive interface between the two domains, which results in significant structural changes in the phosphatase domain.
the expression and intrinsic phosphatase activity of the lipid phosphatase SHIP2 is increased in human colorectal cancer, and that increased expression within a large cohort of CRC (Montrer CALR Anticorps) patient is correlated to a worse patient survival. SHIP2 functions as an oncogene (Montrer RAB1A Anticorps), by enhancing cell migration and invasion, and reducing cell adhesion in colorectal cancer cells.
HIP2 (Montrer UBE2K Anticorps) regulates mitotic spindle alignment. SHIP2 is expressed in G1 phase, whereas Aurora A kinase (Montrer AURKA Anticorps) is enriched in mitosis. SHIP2 binds Aurora A kinase (Montrer AURKA Anticorps) and the scaffolding protein HEF1 (Montrer NEDD9 Anticorps) and promotes their basolateral localization at the expense of their luminal expression connected with cilia resorption.
article focuses on the mutations associated with opsismodysplasia and explores the role of INPPL1/ SHIP2 in skeletal development (Review)
SHIP2 recruits Mena (Montrer EGFR Anticorps) to invadopodia and disruption of SHIP2-Mena (Montrer EGFR Anticorps) interaction in cancer cells leads to attenuated capacity for ECM (Montrer MMRN1 Anticorps) degradation and invasion in vitro, as well as reduced metastasis in vivo.
In glioblastoma 1321 N1 cells, we recently identified Myo1c (Montrer MYO1C Anticorps) as a new interactor of SHIP2. SHIP2 localization at lamellipodia and ruffles is impaired in Myo1c (Montrer MYO1C Anticorps) depleted cells. In the absence of Myo1c (Montrer MYO1C Anticorps), N1 cells tend to associate to form clusters.
decreased expression of transcription factor Sp1 (Montrer SP1 Anticorps) contributes to suppression of SHIP2 in gastric cancer cells.
In order to shed light on the role of the C2 related (C2R) domain, immediately C-terminal to the SHIP2 phosphatase domain, molecular cloning, expression, purification and crystallization of the human SHIP2 fragment containing the phosphatase (Ptase) and C2R domains were performed an X-ray crystallographic data analysis was conducted.
Regulation of phosphatidylinositol 4,5-bisphosphate by SHIP2 controls glioblastoma cell migration through the organization of focal adhesions.

Mouse (Murine) Inositol Polyphosphate Phosphatase-Like 1 (INPPL1) interaction partners

Inactivation of SHIP2 leads to increased microvilli formation and solute reabsorption by the renal proximal tubule and was associated with hyperactivated ezrin/radixin/moesin (Montrer MSN Anticorps) proteins and increased Rho-GTP (Montrer AK3 Anticorps).
data suggest that endothelial SHIP2 is required to maintain normal systemic glucose homeostasis and prevent oxidative stress-induced (Montrer SQSTM1 Anticorps) endothelial dysfunction.
The authors concluded that the FcgammaRIIb-SHIP2 axis links Abeta (Montrer APP Anticorps) neurotoxicity to tau pathology by dysregulating phosphoinositide metabolism, providing insight into therapeutic potential against Alzheimer's disease.
These findings suggest that palmitate contributes to SHIP2 overexpression in skeletal muscle via the mechanisms involving the activation of ceramide-JNK (Montrer MAPK8 Anticorps) and NF-kappaB (Montrer NFKB1 Anticorps) pathways.
results suggest that SHIP2 contributes to the regulation of food intake mainly via the attenuation of insulin (Montrer INS Anticorps) signalling in the hypothalamus of mice
The catalytically-inactive Ship2 mutant protein in a context of reduced PtdIns(4,5)P2 3-kinase activity.
Regulation of insulin signaling and glucose transporter 4 (GLUT4) exocytosis by phosphatidylinositol 3,4,5-trisphosphate (PIP3) phosphatase, skeletal muscle, and kidney enriched inositol polyphosphate phosphatase (SKIP).
These results suggest that SHIP2 is a potent negative regulator of insulin (Montrer INS Anticorps)/IGF-I (Montrer IGF1 Anticorps) actions in the brain, and excess amounts of SHIP2 may be related, at least in part, to brain dysfunction in insulin (Montrer INS Anticorps) resistance with type 2 diabetes.
The SHIP2 is a negative regulator of insulin (Montrer INS Anticorps) signaling, our findings suggest the importance of the phosphoinositide metabolism at endocytic clathrin-coated pits in the regulation of insulin (Montrer INS Anticorps) signal output.
Association with the insulin (Montrer INS Anticorps) resistance of diabetic db/db (Montrer LEPR Anticorps) mice.

Pig (Porcine) Inositol Polyphosphate Phosphatase-Like 1 (INPPL1) interaction partners

we suggest that SHIP2 might play a role in the regulation of skeletal muscle development in pigs

Inositol Polyphosphate Phosphatase-Like 1 (INPPL1) profil antigène

Antigen Summary

The protein encoded by this gene is an SH2-containing 5'-inositol phosphatase that is involved in the regulation of insulin function. The encoded protein also plays a role in the regulation of epidermal growth factor receptor turnover and actin remodelling. Additionally, this gene supports metastatic growth in breast cancer and is a valuable biomarker for breast cancer.

Alternative names and synonyms associated with Inositol Polyphosphate Phosphatase-Like 1 (INPPL1)

inositol polyphosphate phosphatase-like 1b (inppl1b) anticorps
inositol polyphosphate phosphatase like 1 (INPPL1) anticorps
phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2B (LOC100180571) anticorps
inositol polyphosphate phosphatase-like 1 (Inppl1) anticorps

51C anticorps
INPPL1 anticorps
OPSMD anticorps
Ship2 anticorps
si:bz46j2.7 anticorps
si:rp71-46j2.7 anticorps

Protein level used designations for INPPL1

SH2-domain-containing inositol 5-phosphatase 2b , inositol polyphosphate phosphatase-like 1 , ship2b , phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2-like , 51C protein , INPPL-1 , SH2 domain-containing inositol 5'-phosphatase 2 , SH2 domain-containing inositol-5'-phosphatase 2 , SHIP-2 , phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 , phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2 , protein 51C , SH2 domain-containing inositol phosphatase 2 , ablSH3-binding protein , inositol polyphosphate phosphatase-like protein 1 , SH2-containing inositol phosphatase 2

GENE ID	SPECIES
368433	Danio rerio
428692	Gallus gallus
451403	Pan troglodytes
100339369	Oryctolagus cuniculus
100482460	Ailuropoda melanoleuca
100180571	Ciona intestinalis
100596562	Nomascus leucogenys
3636	Homo sapiens
16332	Mus musculus
65038	Rattus norvegicus
485209	Canis lupus familiaris
783833	Bos taurus
100462718	Sus scrofa

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