Use your antibodies-online credentials, if available.
Il n’y a pas de produits dans votre liste de comparaison.
Votre panier est vide.
Afficher tous les synonymes
Sélectionnez vos espèces d'intérêt
Myeloid cell derived tissue factor dampens inflammation in acid-induced acute lung injury.
Ticagrelor, but not clopidogrel, reduces arterial thrombosis via endothelial tissue factor suppression. Ticagrelor reduced TNF-alpha (Montrer TNF Protéines)-induced TF expression via proteasomal degradation.
Macrophage tissue factor prothrombotic activity is regulated by integrin-alpha4/arf6 (Montrer ARF6 Protéines) trafficking.
Evening primrose oil and forskolin decreased the prothrombotic effect of celecoxib initiated by a LPS (Montrer TLR4 Protéines) challenge in mice, and this effect was, at least partly, mediated by mitigating TF expression and activity.
Thrombin (Montrer F2 Protéines)-independent contribution of tissue factor to inflammation and cardiac hypertrophy in a mouse model of sickle cell disease.
These findings reveal a novel biological function and mechanism of the protein C (Montrer PROC Protéines) pathway in which protein S and the aPC (Montrer APC Protéines)-cleaved form of fV are cofactors for anti-inflammatory cell signaling by aPC (Montrer APC Protéines) in the context of endotoxemia and infection
Lung epithelial tissue factor regulates alveolar procoagulant activity and permeability in acute lung injury.
PGE2 increases both TF expression and activity through the regulation of the EP1 (Montrer PTGER1 Protéines)/SIRT1 (Montrer SIRT1 Protéines) pathway.
Fas (Montrer FAS Protéines)-initiated, caspase-3 (Montrer CASP3 Protéines)-dependent hepatocyte apoptosis increases tissue factor procoagulant activity through a mechanism involving phosphatidylserine externalization.
Heme promotes tissue factor-dependent coagulation activation and induces tissue factor expression on leukocytes in vivo.
uPAR (Montrer PLAUR Protéines) and TF could potentially be attractive targets for molecular imaging and therapy in oral squamous cell carcinoma due to high positive expression rates and tumor-specific expression patterns.
The highest tissue factor activity was detected in microparticles from monocytes, lower activity - in microparticles from endothelial cells and THP-1 cells, and no activity - in microparticles from platelets and granulocytes.
Patients with early onset preeclampsia are characterised by an attenuated coagulation response characterised by reduced thrombin (Montrer F2 Protéines) generation stimulated by low-dose TF and elevated plasma TFPI (Montrer TFPI Protéines) activity.
The proinflammatory cytokine IL-33 (Montrer IL33 Protéines) induces differential tissue factor expression and activity in monocyte subsets, as well as the release of procoagulant microvesicless. In this manner, IL-33 (Montrer IL33 Protéines) may contribute to the formation of a prothrombotic state characteristic for cardiovascular disease.
Pin1 (Montrer PIN1 Protéines) is a fast-acting enzyme which may be utilised by cells to protect the phosphorylation state of TF in activated cells prolonging TF activity and release, and therefore ensuring adequate haemostasis.
Circulating pentraxin nCRP has little pro-angiogenic effect but when dissociated into mCRP on the surface of endothelial cells it is able to trigger potent proangiogenic effects by inducing F3-gene upregulation and TF signaling.
In the presence of tissue factor-positive cancer cells, the CAR-modified T cells (TF-CAR T) were highly activated and showed specific cytotoxicity to TF-positive cancer cells.
TF is an angiogenic-specific receptor and the target molecule for fVII (Montrer F7 Protéines)-targeted therapeutics.
It was demonstrated that the nature of the clot (Montrer TXNDC17 Protéines) formed, as determined from the quartz crystal microbalance parameters, was highly dependent on the rate of clot (Montrer TXNDC17 Protéines) formation resulting from the TF concentration used for activation. These parameters could also be related to physical clot (Montrer TXNDC17 Protéines) characteristics such as fibrin fibre diameter and fibre density, as determined by scanning electron microscopic image analysis.
Through induction of TF in vascular endothelial cells, IL-33 (Montrer IL33 Protéines) could enhance their thrombotic capacity and thereby might impact on thrombus formation in the setting of atherosclerosis.
Arterial (18)F-fluorodeoxyglucose uptake reflects balloon catheter-induced thrombus formation and tissue factor expression via nuclear factor-kappaB in rabbit atherosclerotic lesions.
Polycations could present a new class of anticoagulants with such unique upstream downregulation of blood coagulation, selectively blocking tissue factor-dependent factor VII (Montrer TH Protéines) activation.
Upregulated TF expression and increased plasma TF level during reperfusion period, reduced plasma TFPI-1 (Montrer TFPI Protéines) level during reperfusion period.
lectin-like oxidized LDL receptor (Montrer OLR1 Protéines) Oxidized low-density lipoprotein receptor (Montrer LDLR Protéines) 1expression appears to be closely associated with tissue factor expression, apoptotic events and morphological vulnerability in atherosclerotic lesions
Tissue factor expression on porcine neonatal islet cell clusters is an important initiator of instant blood-mediated inflammatory reaction in islet xenotransplantation.
Prolonged clopidogrel treatment reduced coronary tissue factor (TF) expression and tended to reduce the blood TF level post-PCI (Montrer SERPINA5 Protéines), thus possibly modulating the risk of late thrombosis.
Procoagulant porcine tissue factor is induced in primary pig aortic endothelial cells only by fresh human plasma, and not by heat-inactivated plasma.
myocardial infarction induced proinflammatory gene and protein expression in peripheral blood mononuclear cells of tissue factor cyclo-oxygenase-2, monocyte chemoattractant protein-1 (Montrer CCL2 Protéines) and CRP (Montrer CRP Protéines)
This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.
, coagulation factor III
, tissue factor
, brain tissue factor
, coagulation factor 3