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Human Polyclonal MEFV Primary Antibody pour WB - ABIN1881537
Cosan, Ustek, Oku, Duymaz-Tozkir, Cakiris, Abaci, Ocal, Aral, Gül: Association of familial Mediterranean fever-related MEFV variations with ankylosing spondylitis. dans Arthritis and rheumatism 2010
Show all 4 Pubmed References
Human Polyclonal MEFV Primary Antibody pour ELISA, WB - ABIN269824
Rabinovich, Livneh, Langevitz, Brezniak, Shinar, Pras, Shinar: Severe disease in patients with rheumatoid arthritis carrying a mutation in the Mediterranean fever gene. dans Annals of the rheumatic diseases 2005
Human Polyclonal MEFV Primary Antibody pour IP, WB - ABIN1169260
Papin, Cuenin, Agostini, Martinon, Werner, Beer, Grütter, Grütter, Tschopp: The SPRY domain of Pyrin, mutated in familial Mediterranean fever patients, interacts with inflammasome components and inhibits proIL-1beta processing. dans Cell death and differentiation 2007
Human Polyclonal MEFV Primary Antibody pour ELISA, WB - ABIN561791
Taskiran, Cetinkaya, Balci-Peynircioglu, Akkaya, Yilmaz: The effect of colchicine on pyrin and pyrin interacting proteins. dans Journal of cellular biochemistry 2012
Contrary to the NLRP3 (Montrer NLRP3 Anticorps) mutations described in cryopyrin (Montrer NLRP3 Anticorps)-associated periodic syndrome, FMF-associated MEFV mutations do not lead to a constitutive activation of Pyrin. Rather, FMF-associated mutations are hypermorphic mutations that specifically decrease the activation threshold of the Pyrin inflammasome without affecting other canonical inflammasomes.
There was a statistically significant different response to surgical treatment between patients with periodic fever, aphthosis, pharyngitis, and adenitis (PFAPA) Syndrome with and without coexistence of Familial Mediterranean Fever features and MEFV mutations.
The study indicates that the MEFV M694V mutation may contribute to the pathogenesis of ankylosing spondylitis. (Meta-analysis)
The authors evaluated the distribution of MEFV mutations in a Turkish population. Their findings confirm the correlation between M694V and FMF associated amyloidosis found in earlier studies.
we found a significant association between genotypes of variants in rs3743930 with increased Henoch-Schonlein purpura risk, after covariates adjustment. The carriers of homozygous mutant of rs3743930 polymorphisms revealed increased HSP risk than those with wild-type homozygotes.
MEFV gene variations in exons 2, 3, 5 and 10 associate with major clinical symptoms of familial Mediterranean fever. Arthritis was high in K695R heterozygous genotype.
These results provide a novel mechanism underlying the anti-inflammatory effects of carbon monoxide, involving the IL-10 (Montrer IL10 Anticorps)-dependent upregulation of pyrin expression.
High carriage rates of MEFV gene mutations in gouty arthritis suggest that it may play an important role in the pathogenesis of the disease and predisposition to the disease.
The p.M694del variant is associated with autosomal dominantly inherited FMF in Northern European Caucasians.
Inflammatory bowel disease patients, in populations with a high background carrier rate of MEFV variants, should be screened for MEFV gene mutations, especially those diagnosed as indeterminate colitis.
Mechanistically, Yersinia pseudotuberculosis YopM recruits and activates the mouse host kinases PRK1 (Montrer PKN1 Anticorps) and PRK2 (Montrer PKN2 Anticorps) to negatively regulate pyrin by phosphorylation.
These results are consistent with a model in which pyrin acts to limit the release of IL-1beta (Montrer IL1B Anticorps) generated by activation and assembly of inflammasomes in response to subclinical immune challenges.
pyrin has a critical role in the innate immune response, possibly by acting on ASC (Montrer STS Anticorps), a known caspase-1 (Montrer CASP1 Anticorps) activator
This gene encodes a protein, also known as pyrin or marenostrin, that is an important modulator of innate immunity. Mutations in this gene are associated with Mediterranean fever, a hereditary periodic fever syndrome.
Mediterranean fever protein
, Mediterranean fever
, familial mediterranean fever