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C-terminal cytoplasmic fragment of PcdhgC5 (Montrer PCDHGC5 Kits ELISA) acts as a scaffold for CaMKP and CaMKI (Montrer CAMK1 Kits ELISA) to regulate CaMKP activity.
The POPX2 phosphatase regulates cancer cell motility and invasiveness.
The binding of POPX2 (PPM1F) to mDia1 or to an mDia-containing complex greatly decreases the ability of mDia1 to activate transcription from the serum response element (SRE).
This study, combined with our previous findings, suggests that a single ubiquitously expressed phosphatase POPX2 influences cancer metastasis via modulating multiple biological processes including MAPK (Montrer MAPK1 Kits ELISA) signaling and exosome cytokine secretion.
Overexpression of PPM1F is associated with metastasis of hepatocellular carcinoma.
POPX2 affects trafficking by determining the phosphorylation status of KIF3A (Montrer KIF3A Kits ELISA) at serine 690.
POPX2 might regulate cell motility through its regulation of the MAPK1 (Montrer MAPK3 Kits ELISA)/3, leading to changes in the cytoskeleton and cell motility.
hCaMKP activity is reversibly regulated by oxidation/reduction at Cys (Montrer DNAJC5 Kits ELISA)-359
FHOD1 (Montrer FHOD1 Kits ELISA) and PPM1F (direct regulators of the actin cytoskeleton) were identified as novel targets of miR (Montrer MLXIP Kits ELISA)-200c. Expression levels of FHOD1 (Montrer FHOD1 Kits ELISA) and PPM1F were inversely correlated with miR (Montrer MLXIP Kits ELISA)-200c level in breast cancer cell lines and breast cancer patient samples.
Data identify a biochemical pathway through which POPX2 exerts its apparent cellular function: the regulation of activity of glycogen synthase kinase-3 (Montrer GSK3b Kits ELISA), which in turn modulates extracellular signal-regulated kinase and cell motility.
The p21 (Montrer CDKN1A Kits ELISA)-activated kinase PAK is negatively regulated by POPX1 (Montrer PPM1E Kits ELISA) and POPX2, a pair of serine/threonine phosphatases of the PP2C family. (POPX1 (Montrer PPM1E Kits ELISA); POPX2)
PPM1F plays a key role in the regulation of CaMKII (Montrer CAMK2G Kits ELISA) intracellularly
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase can interact with Rho guanine nucleotide exchange factors (PIX), and thus block the effects of p21-activated kinase 1 (PAK), a protein kinase mediating biological effects downstream of Rho GTPases. Calcium/calmodulin-dependent protein kinase II gamma (CAMK2G/CAMK-II) is found to be one of the substrates of this phosphatase. The overexpression of this phosphatase or CAMK2G has been shown to mediate caspase-dependent apoptosis. An alternatively spliced transcript variant has been identified, but its full-length nature has not been determined.
ca(2+)/calmodulin-dependent protein kinase phosphatase
, caM-kinase phosphatase
, calcium/calmodulin-dependent protein kinase phosphatase
, partner of PIX2
, protein phosphatase 1F
, Ca(2+)/calmodulin-dependent protein kinase phosphatase
, CaM-kinase phosphatase
, PP2C phosphatase
, partner of PIX 2
, protein fem-2 homolog
, protein phosphatase 1F (PP2C domain containing)