Aperçu des produits pour anti-ASXL2 (ASXL2) Anticorps

Human Additional Sex Combs Like 2 (Drosophila) (ASXL2) interaction partners

1. Incidence and prognostic impact of ASXL2 mutations in adult acute myeloid leukemia patients with t(8;21)(q22;q22): a study of the German-Austrian AML Study Group.

2. ASXL2 and ZBTB7A mutations were frequently identified in Japanese AML patients with t(8;21), but not in those with inv(16). Further analysis is required to clarify the detailed biological mechanism of AE9a regulation of the cohesin complex.

3. Loss of ASXL2 expression is associated with tumorigenesis.

4. ASXL2 is essential for haematopoiesis and acts as a haploinsufficient tumour suppressor in leukemia.

5. Infrequent occurrence of TET1, TET3, and ASXL2 mutations in myelodysplastic/myeloproliferative neoplasms

6. Data indicate higher ASXL2 expression in ERalpha-positive patients, suggesting that ASXL2 could be a prognostic marker in breast cancer.

7. Mutation in ASXL2 is associated with core-binding factor acute myeloid leukemia.

8. ASXL2 mutation is associated with acute myeloid leukemia.

9. de novo truncating variants in ASXL2 underlie a neurodevelopmental syndrome with a clinically recognizable phenotype; this report expands the germline disorders that are linked to the ASXL genes

10. inactivation of the BAP1/ASXL2 axis might contribute to cancer development.

11. ASXL1, ASXL2 and ASXL3 are epigenetic scaffold proteins that are involved in the pathogenesis of non-cancerous diseases and cancers.[Review]

12. identify a high-frequency mutation in t(8;21)/RUNX1-RUNX1T1 acute myekoid leukemia (AML) and identify the need for future studies to investigate the clinical and biological relevance of ASXL2 mutations in this unique subset of AML

13. WTIP interacts with ASXL2 and blocks ASXL2-mediated activation of retinoic acid signaling.

14. ASXL1 represses, whereas ASXL2 increases, the expression of adipogenic genes, most of which are PPARgamma targets

15. the apparent occurrence of an unusual TG 3' splice site in intron 2 is discussed

Mouse (Murine) Additional Sex Combs Like 2 (Drosophila) (ASXL2) interaction partners

1. ASXL2 functions as a tumour suppressor to maintain normal Hematopoietic stem cell function.

2. ASXL2 is essential for haematopoiesis and acts as a haploinsufficient tumour suppressor in leukemia.

3. ASXL2 is a master regulator of skeletal, lipid, and glucose homeostasis

4. Asxl2-/- neonates have patent ductus arteriosus and consequent lung hemorrhage and die soon after birth.

5. ASXL2 and WTIP are expressed in mouse embryonic epicardial cells. ASXL2 and WTIP participate in regulation of retinoic acid signaling during heart development.

6. ASXL2 and PRC2 interact in the adult heart and co-localize to target promoters.

7. Chromatin factors like Asxl2 function in the adult heart to regulate cell type- and stage-specific patterns of gene expression.

8. the knockdown of Asxl2 in bone marrow macrophages impaired their ability to form osteoclasts.