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anti-Rat (Rattus) ASXL2 Anticorps:
anti-Human ASXL2 Anticorps:
anti-Mouse (Murine) ASXL2 Anticorps:
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Infrequent occurrence of TET1 (Montrer TET1 Anticorps), TET3 (Montrer TET3 Anticorps), and ASXL2 mutations in myelodysplastic/myeloproliferative neoplasms
Data indicate higher ASXL2 expression in ERalpha (Montrer ESR1 Anticorps)-positive patients, suggesting that ASXL2 could be a prognostic marker in breast cancer.
Mutation in ASXL2 is associated with core-binding factor (Montrer CBFB Anticorps) acute myeloid leukemia (Montrer BCL11A Anticorps).
ASXL2 mutation is associated with acute myeloid leukemia (Montrer BCL11A Anticorps).
de novo truncating variants in ASXL2 underlie a neurodevelopmental syndrome with a clinically recognizable phenotype; this report expands the germline disorders that are linked to the ASXL genes
inactivation of the BAP1 (Montrer RNF2 Anticorps)/ASXL2 axis might contribute to cancer development.
ASXL1, ASXL2 and ASXL3 are epigenetic scaffold proteins that are involved in the pathogenesis of non-cancerous diseases and cancers.[Review]
identify a high-frequency mutation in t(8;21)/RUNX1 (Montrer RUNX1 Anticorps)-RUNX1T1 (Montrer RUNX1T1 Anticorps) acute myekoid leukemia (AML (Montrer RUNX1 Anticorps)) and identify the need for future studies to investigate the clinical and biological relevance of ASXL2 mutations in this unique subset of AML (Montrer RUNX1 Anticorps)
WTIP interacts (Montrer WTIP Anticorps) with ASXL2 and blocks ASXL2-mediated activation of retinoic acid (Montrer WTIP Anticorps)signaling.
ASXL1 (Montrer ASXL1 Anticorps) represses, whereas ASXL2 increases, the expression of adipogenic genes, most of which are PPARgamma (Montrer PPARG Anticorps) targets
ASXL2 is a master regulator of skeletal, lipid, and glucose homeostasis
Asxl2-/- neonates have patent ductus arteriosus and consequent lung hemorrhage and die soon after birth.
ASXL2 and WTIP (Montrer WTIP Anticorps) are expressed in mouse embryonic epicardial cells. ASXL2 and WTIP (Montrer WTIP Anticorps) participate in regulation of retinoic acid signaling during heart development.
ASXL2 and PRC2 interact in the adult heart and co-localize to target promoters.
Chromatin factors like Asxl2 function in the adult heart to regulate cell type- and stage-specific patterns of gene expression.
the knockdown of Asxl2 in bone marrow macrophages impaired their ability to form osteoclasts.
ASXL2 is a human homolog of the Drosophila asx gene. Drosophila asx is an enhancer of trithorax (see MIM 159555) and polycomb (see MIM 610231) (ETP) gene that encodes a chromatin protein with dual functions in transcriptional activation and silencing (Katoh and Katoh, 2003
additional sex combs like 2
, additional sex combs like 2 (Drosophila)
, chimeric MOZ-ASXH2 fusion protein-like
, putative Polycomb group protein ASXL2-like
, additional sex combs-like protein 2
, polycomb group protein ASXH2
, putative Polycomb group protein ASXL2
, polycomb group protein ASXH2 homolog