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FcRn Anticorps

(IgG receptor FcRn (FcRn))

The neonatal Fc receptor (FnRn) owes its name to being the receptor that transports maternal IgG from mother to lactating neonatal offspring and for being identified first in the intestine of neonatal rats as the receptor responsible for the transport of IgG from the lumen to the circulation. However, FcRn functions are far more universal, and it is virtually ubiquitously expressed.

FcRn is considered a non-classical Fc receptor for IgG (FcγR). It is structurally related to major histocompatibility class I (MHC-I) family and it associates with beta-2-microglobulin (β2m). On the other hand, it does not present antigenic peptides to T cells and. It has also a second interaction partner, albumin, that is not involved in the body’s immune response. FcRn prevents intracellular degradation of IgG and albumin and extends their half-life considerable, making them the two most abundant serum proteins.

Because of its interaction with IgG and albumin, FcRn has become a high-interest therapeutic target. For one, it can be exploited to extend the half-life of therapeutic antibodies and IgG- or albumin-fused proteins. Mutations of amino acids influencing the pH dependency of IgG and albumin binding can be mutated to achieve the desired effect. Binding of IgG to FcRn also offers the possibility to enhance their clearance. Autoantibodies that recognized self-antigens are the cause of certain autoimmune diseases. By engineering competing antibodies that bind tighter to FcRn and effectively block the receptor increase clearance of the disease-causing antibodies. Lastly, the FcRn enhances the transport of therapeutic IgG fc or albumin fusion-protein across mucosal membranes, thus facilitating distribution and improving their absorption.

Anti-FcRn antibodies are essential tools to elucidate the biological function of FcRn under normal circumstances and in pathologies such as autoimmune disease and cancer. They enable FcRn imaging in tissue using IHC or IF and quantitation through FACS. As blocking reagents they are useful to identify epitopes on FcRn targeted by antibody-based drugs or albumin-conjugated therapeutics. They can also use autoantibody recycling and influence the half-life of therapeutic antibodies.

Albumin and IgG binding to FcRn-β2m - antibodies-online.com

Binding of albumin (orange) and IgG (purple) to the FcRn-β2m heterodimer based on PDB structure 4N0U. Under mildly acidic conditions, glutamate and aspartate residues in the CH2 and CH3 domains of one IgG Fc fragment form hydrogen bonds with histidine residues in the α2 domains of two FcRn molecules. Albumin binds via its DIII and DI domains at a 1:1 stoichiometry to FcRn in a different region. Antibody blocking assays suggest that anti-FcRn antibody clones ADM31 (ABIN1774762) and ADM32 bind to the FcRn-β2m heterodimer within the albumin binding region whereas clone DVN24 (ABIN1774763) and DVN21 block IgG binding.

FcRn anticorps FcRn anticorps FcRn anticorps (ABIN1774762)

FcRn Reactivité: Humain ELISA, IF, FACS, cELISA, Func Hôte: Souris Monoclonal ADM31 unconjugated

FcRn anticorps  (AA 24-297) FcRn anticorps  (AA 24-297) FcRn anticorps (AA 24-297) (ABIN7156043)

FcRn Reactivité: Humain WB, ELISA, IHC, IF Hôte: Lapin Polyclonal unconjugated

FcRn anticorps  (AA 24-365) FcRn anticorps  (AA 24-365) FcRn anticorps (AA 24-365) (ABIN7441535)

FcRn Reactivité: Humain WB, IHC, IP, ICC Hôte: Lapin Polyclonal unconjugated

FcRn Anticorps par Réactivité

Trouvez FcRn Anticorps pour une variété d'espèces telles que anti-Human FcRn, anti-Mouse FcRn, anti-Cynomolgus FcRn. Les espèces listées ci-dessous sont parmi celles disponibles. Cliquez sur un lien pour accéder aux produits correspondants.

FcRn Anticorps par Application

Trouver FcRn Anticorps validé pour une application spécifique telle que WB, ELISA, IHC, FACS. Certaines des applications disponibles sont énumérées ci-dessous. Cliquez sur un lien pour accéder aux produits correspondants

FcRn Anticorps par Hote

On trouve ici des FcRn Anticorps avec un Hote spécifique. Les Hote mentionnés ici sont quelques-uns de ceux qui sont disponibles. Un clic sur le lien correspondant permet d'accéder aux produits

FcRn Anticorps par Epitope

Trouver FcRn Anticorps avec un épitope spécifique. Les épitopes listés ci-dessous sont parmi ceux disponibles. Cliquez sur un lien pour accéder aux produits correspondants.

FcRn Anticorps par Clonalité

Trouvez les FcRn Anticorps monoclonaux ou polyclonaux disponibles. Cliquez sur un lien pour accéder aux produits correspondants.

FcRn Anticorps par Clone

On trouve ici des FcRn Anticorps avec un Clone spécifique. Les Clone mentionnés ici sont quelques-uns de ceux qui sont disponibles. Un clic sur le lien correspondant permet d'accéder aux produits

FcRn Anticorps par Conjugué

Trouvez FcRn Anticorps avec un conjugué spécifique tel que Biotin, FITC, HRP. Les conjugués listés ci-dessous sont parmi ceux disponibles. Cliquez sur un lien pour accéder aux produits correspondants.

FcRn Anticorps fréquemment utilisés

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application ELISA, IF, FACS, cELISA, Func
Validations
  • (15)
  • (6)
N° du produit ABIN1774762
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Application WB, ELISA, IHC, IF
Validations
  • (7)
N° du produit ABIN7156043
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Application WB, IHC, IP, ICC
Validations
  • (4)
N° du produit ABIN7441535
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human
Application WB, ELISA, IHC, ICC, FACS, Neut
Validations
  • (4)
N° du produit ABIN7193244
Quantité 0.1 mg
Fiche technique Fiche technique
Reactivity Human
Application WB, ELISA, IHC, ICC, FACS, Neut
Validations
  • (4)
N° du produit ABIN7193245
Quantité 0.1 mg
Fiche technique Fiche technique
Reactivity Human
Application IHC, ISt, StM
Validations
  • (4)
N° du produit ABIN6939380
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Application WB
Validations
  • (2)
N° du produit ABIN1537146
Quantité 400 μL
Fiche technique Fiche technique
Reactivity Human
Application WB, IF
Validations
  • (2)
N° du produit ABIN6140552
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human, Mouse
Application ELISA, IF, FACS, cELISA
Validations
  • (2)
  • (2)
N° du produit ABIN1774763
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Cow, Dog, Guinea Pig, Horse, Human, Mouse, Sheep
Application WB, IHC
Validations
  • (3)
N° du produit ABIN2782616
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human
Application WB
Validations
  • (1)
N° du produit ABIN321108
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Mouse
Application WB, ELISA, IHC (p)
Validations
  • (2)
N° du produit ABIN3044522
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Application WB, IHC (p)
Validations
  • (2)
N° du produit ABIN3044521
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Application ELISA
Validations
N° du produit ABIN7156046
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Application
Validations
N° du produit ABIN7156045
Quantité 100 μg
Fiche technique Fiche technique

Dernières publications pour nos FcRn Anticorps

Xu, He, Momben-Abolfath, Vertrees, Li, Norton, Struble: "Zika Virus Infection and Antibody Neutralization in FcRn Expressing Placenta and Engineered Cell Lines." dans: Vaccines, Vol. 10, Issue 12, (2022) (PubMed).

Gjølberg, Frick, Mester, Foss, Grevys, Høydahl, Jørstad, Schlothauer, Sandlie, Moe, Andersen: "Biophysical differences in IgG1 Fc-based therapeutics relate to their cellular handling, interaction with FcRn and plasma half-life." dans: Communications biology, Vol. 5, Issue 1, pp. 832, (2022) (PubMed).

Cines, Zaitsev, Rauova, Rux, Stepanova, Krishnaswamy, Sarkar, Kowalska, Zhao, Mast, Blumberg, McCrae, Poncz, Hubbard, Pyzik, Blumberg: "FcRn augments induction of tissue factor activity by IgG-containing immune complexes." dans: Blood, Vol. 135, Issue 23, pp. 2085-2093, (2021) (PubMed).

Hubbard, Pyzik, Rath, Kozicky, Sand, Gandhi, Grevys, Foss, Menzies, Glickman, Fiebiger, Roopenian, Sandlie, Andersen, Sly, Baker, Blumberg: "FcRn is a CD32a coreceptor that determines susceptibility to IgG immune complex-driven autoimmunity." dans: The Journal of experimental medicine, Vol. 217, Issue 10, (2021) (PubMed).

Bern, Nilsen, Ferrarese, Sand, Gjølberg, Lode, Davidson, Camire, Bækkevold, Foss, Grevys, Dalhus, Wilson, Høydahl, Christianson, Roopenian, Schlothauer, Michaelsen, Moe, Lombardi, Pinotti, Sandlie et al.: "An engineered human albumin enhances half-life and transmucosal delivery when fused to protein-based biologics. ..." dans: Science translational medicine, Vol. 12, Issue 565, (2021) (PubMed).

Casulleras, Flores-Costa, Duran-Güell, Alcaraz-Quiles, Sanz, Titos, López-Vicario, Fernández, Horrillo, Costa, de la Grange, Moreau, Arroyo, Clària: "Albumin internalizes and inhibits endosomal TLR signaling in leukocytes from patients with decompensated cirrhosis." dans: Science translational medicine, Vol. 12, Issue 566, (2021) (PubMed).

Catlin, Mitchell, Potchoiba, OHara, Wang, Zhang, Weinbauer, Bowman: "Placental transfer of 125 iodinated humanized immunoglobulin G2Δa in the cynomolgus monkey." dans: Birth defects research, Vol. 112, Issue 1, pp. 105-117, (2020) (PubMed).

Blumberg, Humphries, Jones, Pearce, Holgate, Hearn, Cheung, Mahmood, Del Tito, Graydon, Stolz, Bitonti, Purohit, de Graaf, Kacena, Andersen, Christianson, Roopenian, Hubbard, Gandhi, Lasseter, Pyzik et al.: "Blocking FcRn in humans reduces circulating IgG levels and inhibits IgG immune complex-mediated immune responses. ..." dans: Science advances, Vol. 5, Issue 12, pp. eaax9586, (2020) (PubMed).

Bequignon, Dhommée, Angely, Thomas, Bottier, Escudier, Isabey, Coste, Louis, Papon, Gouilleux-Gruart: "FcRn-Dependent Transcytosis of Monoclonal Antibody in Human Nasal Epithelial Cells In Vitro: A Prerequisite for a New Delivery Route for Therapy?" dans: International journal of molecular sciences, Vol. 20, Issue 6, (2019) (PubMed).

Chung, Nguyen, Lin, Lafrance-Vanasse, Scales, Lin, Deng, Williams, Sperinde, Li, Zheng, Sukumaran, Tesar, Ernst, Fischer, Lazar, Prabhu, Song: "An in vitro FcRn- dependent transcytosis assay as a screening tool for predictive assessment of nonspecific clearance of antibody therapeutics in humans." dans: mAbs, Vol. 11, Issue 5, pp. 942-955, (2019) (PubMed).

Pseudonymes pour FcRn Anticorps

Fc fragment of IgG receptor and transporter (FCGRT) Anticorps
Fc fragment of IgG receptor and transporter (Fcgrt) Anticorps
Fc receptor, IgG, alpha chain transporter (Fcgrt) Anticorps
alpha-chain Anticorps
FCRN Anticorps
FcRn Anticorps
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