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Human SEMA7A Protein expressed in Wheat germ - ABIN1319500
Gan, Reilkoff, Peng, Russell, Chen, Mathai, Homer, Gulati, Siner, Elias, Bucala, Herzog: Role of semaphorin 7a signaling in transforming growth factor ?1-induced lung fibrosis and scleroderma-related interstitial lung disease. dans Arthritis and rheumatism 2011
Sema7A has a significant role in atherosclerosis by mediating endothelial dysfunction in a beta1 integrin-dependent manner.
Sema7A-PlxnC1 interaction is essential to form the post-synaptic assembly.
During differentiation of adult-born dentate gyrus granule cells, Sema7A promotes dendrite growth, complexity and spine development through beta1-subunit-containing integrin receptors.
Genetic ablation of host-derived SEMA7A further enhanced the antitumor effects of SEMA7A shRNA gene silencing in 4T1 cells. Our preclinical findings demonstrate a critical role for SEMA7A in mediating mammary tumor progression.
sema7A is involved in peripheral immunity and central nervous system inflammation in multiple sclerosis pathogenesis.
These findings indicate that Sema7A as a potent activator of T cells and monocytes in the immune response contributes to the inflammation and progression of rheumatoid arthritis
Our results suggest that semaphorin 7a may be novel target for blocking breast tumor progression.
SEMA7A plays a critical role in IgE-mediated neutrophilic airway inflammation
SEMA7A has a role in the development of lung injury
Data suggest that sema7A is involved in the pathogenesis of experimental autoimmune encephalomyelitis, in the modulation of the immune response and in the neurodegeneration that take place in the CNS.
This study demonstrates that Sema7A controls the assembly of actin-based protrusions that drive Dendritic cell migration in response to CCL21.
Sem7a and its receptors regulate Chi3l1 in pulmonary melanoma metastasis
These data identify Sema7A as a regulator of thalamocortical and local circuit development in layer 4 and provide a molecular handle that can be used to explore the coordinated generation of excitatory and inhibitory cortical circuits.
these results suggest that Sema3A and Sema7A have opposite effects and are involved in different stages of synapse elimination.
SEMA7A was expressed in the liver and was increased in the course of liver fibrosis, both in mice and in humans.
Oncogenic Ras may play a role in epithelial mesenchymal transition via the ERF and regulation of Semaphorin-7a.
We report here the expression and induction of semaphorin 7A (SEMA7A) on endothelium through hypoxia-inducible factor 1alpha during hypoxia.
Sema7A mediates signaling through smad6 during West Nile virus infection in an analysis of smad6 expression in cortical neurons from sema7A-deficient mice.
Sema7a is expressed constitutively in the cornea, and potently stimulates nerve regeneration and inflammatory cell influx.
Sema7A plays crucial roles in suppressing intestinal inflammation through alphavbeta1 integrin, but also provides a novel mode of IL-10 induction via interactions between IECs and Mvarphis
short hairpin-mediated silencing of SEMA7A reveals roles for semaphorin 7a in the promotion of DCIS growth, motility and invasion as well as lymphangiogenesis in the tumor microenvironment. Our studies also uncover a relationship between COX-2 and semaphorin 7a expression and suggest that semaphorin 7a promotes tumor cell invasion on collagen and lymphangiogenesis via activation of b1-integrin receptor
Our results identified FGL2, GAL, SEMA4D, SEMA7A, and IDO1 as new candidate genes that could be involved in MSCs-mediated immunomodulation. FGL2, GAL, SEMA4D, SEMA7A, and IDO1 genes appeared to be differentially transcribed in the different MSC populations. Moreover, these genes were not similarly modulated following MSCs-exposure to inflammatory signals
Sema3A and sema7A expression correlated with the inflammatory activity of the multiple sclerosis (MS) lesions, suggesting their involvement in the immunological process that takes place in MS.
These results suggest that SEMA7a plays a role as a CSF biomarkers associated with the conversion to clinically definite multiple sclerosis in clinically isolated syndromes patients
heterozygous missense variants in SEMA3A and SEMA7A may modify the phenotype of Kallmann syndrome but most likely are not alone sufficient to cause the disorder
Semaphorin 7A is a potentially important modulator of eosinophil profibrotic functions in the airway remodeling of patients with chronic asthma.
two MTRAP monomers interact via their tandem TSR domains with the Sema domains of a Semaphorin-7A homodimer
Semaphorin 7A protein variants differentially regulate T-cell activity.
Sema7A markedly reduces the production rates of megakaryocytes and platelets from CD34(+) progenitor cells.
Sema7A on keratinocytes and beta1-integrin on monocytes contribute to monocyte activation by keratinocytes within skin inflammation, inducing IL-8
A new SEMA7A variant was identified in Native American plasma samples, and an alloantibody that recognizes the wild-type protein
Study reports the structures of Sema7A and A39R complexed with the Semaphorin-binding module of PlexinC1; both structures show two PlexinC1 molecules symmetrically bridged by Semaphorin dimers.
Sema7A is a potent stimulator of cytokine production, chemotaxis and superoxide release in monocytes
SEMA 7A might be a molecule involved in the terminal innervation of the dentin-pulp complex.
The protein encoded by this gene binds to cell surfaces through a glycosylphosphatidylinositol (GPI) linkage. The encoded glycoprotein is found on activated lymphocytes and erythrocytes. This protein may be involved in immunomodulatory and neuronal processes. Defects in this gene can result in loss of bone mineral density (BMD). Three transcript variants encoding different isoforms have been found for this gene.
, Semaphorin K1
, sema K1
, sema L
, sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A
, JMH blood group antigen
, John Milton Hagen blood group H-Sema K1
, john-Milton-Hargen human blood group Ag
, sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A (JMH blood group)
, sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, 7A
, semaphorin K1
, semaphorin L
, semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) isoform 1
, semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) isoform 2