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Human SEMA7A Protein expressed in Wheat germ - ABIN1319500
Gan, Reilkoff, Peng, Russell, Chen, Mathai, Homer, Gulati, Siner, Elias, Bucala, Herzog: Role of semaphorin 7a signaling in transforming growth factor ?1-induced lung fibrosis and scleroderma-related interstitial lung disease. dans Arthritis and rheumatism 2011
During differentiation of adult-born dentate gyrus granule cells, Sema7A promotes dendrite growth, complexity and spine development through beta1-subunit-containing integrin receptors.
Genetic ablation of host-derived SEMA7A further enhanced the antitumor effects of SEMA7A shRNA gene silencing in 4T1 cells. Our preclinical findings demonstrate a critical role for SEMA7A in mediating mammary tumor progression.
sema7A is involved in peripheral immunity and central nervous system inflammation in multiple sclerosis pathogenesis.
These findings indicate that Sema7A as a potent activator of T cells and monocytes in the immune response contributes to the inflammation and progression of rheumatoid arthritis
Our results suggest that semaphorin 7a may be novel target for blocking breast tumor progression.
SEMA7A plays a critical role in IgE-mediated neutrophilic airway inflammation
SEMA7A has a role in the development of lung injury
Data suggest that sema7A is involved in the pathogenesis of experimental autoimmune encephalomyelitis, in the modulation of the immune response and in the neurodegeneration that take place in the CNS.
This study demonstrates that Sema7A controls the assembly of actin-based protrusions that drive Dendritic cell migration in response to CCL21 (Montrer CCL21 Protéines).
Sem7a and its receptors regulate Chi3l1 (Montrer CHI3L1 Protéines) in pulmonary melanoma metastasis
short hairpin-mediated silencing of SEMA7A reveals roles for semaphorin 7a in the promotion of DCIS growth, motility and invasion as well as lymphangiogenesis in the tumor microenvironment. Our studies also uncover a relationship between COX-2 and semaphorin 7a expression and suggest that semaphorin 7a promotes tumor cell invasion on collagen and lymphangiogenesis via activation of b1-integrin receptor
Our results identified FGL2 (Montrer FGL2 Protéines), GAL (Montrer GAL Protéines), SEMA4D (Montrer SEMA4D Protéines), SEMA7A, and IDO1 (Montrer IDO1 Protéines) as new candidate genes that could be involved in MSCs-mediated immunomodulation. FGL2 (Montrer FGL2 Protéines), GAL (Montrer GAL Protéines), SEMA4D (Montrer SEMA4D Protéines), SEMA7A, and IDO1 (Montrer IDO1 Protéines) genes appeared to be differentially transcribed in the different MSC (Montrer MSC Protéines) populations. Moreover, these genes were not similarly modulated following MSCs-exposure to inflammatory signals
Sema3A (Montrer SEMA3A Protéines) and sema7A expression correlated with the inflammatory activity of the multiple sclerosis (MS) lesions, suggesting their involvement in the immunological process that takes place in MS.
These results suggest that SEMA7a plays a role as a CSF (Montrer CSF2 Protéines) biomarkers associated with the conversion to clinically definite multiple sclerosis in clinically isolated syndromes patients
heterozygous missense variants in SEMA3A (Montrer SEMA3A Protéines) and SEMA7A may modify the phenotype of Kallmann syndrome but most likely are not alone sufficient to cause the disorder
SEMA7A was expressed in the liver and was increased in the course of liver fibrosis, both in mice and in humans.
Semaphorin 7A is a potentially important modulator of eosinophil profibrotic functions in the airway remodeling of patients with chronic asthma.
The protein encoded by this gene binds to cell surfaces through a glycosylphosphatidylinositol (GPI) linkage. The encoded glycoprotein is found on activated lymphocytes and erythrocytes. This protein may be involved in immunomodulatory and neuronal processes. Defects in this gene can result in loss of bone mineral density (BMD). Three transcript variants encoding different isoforms have been found for this gene.
, Semaphorin K1
, sema K1
, sema L
, sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A
, JMH blood group antigen
, John Milton Hagen blood group H-Sema K1
, john-Milton-Hargen human blood group Ag
, sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A (JMH blood group)
, sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, 7A
, semaphorin K1
, semaphorin L
, semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) isoform 1
, semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) isoform 2