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Human Polyclonal Apelin Primary Antibody pour ELISA, IF - ABIN347115
Daviaud, Boucher, Gesta, Dray, Guigne, Quilliot, Ayav, Ziegler, Carpene, Saulnier-Blache, Valet, Castan-Laurell: TNFalpha up-regulates apelin expression in human and mouse adipose tissue. dans FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006
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Human Polyclonal Apelin Primary Antibody pour WB - ABIN522328
Li, Takai, Yuge, Furukawa, Tsuno, Tsukamoto, Kong, Moriyama, Narahara: Novel target genes responsive to the anti-growth activity of triptolide in endometrial and ovarian cancer cells. dans Cancer letters 2010
Apelin signaling regulates lymphatic development by promoting serine-threonine kinase Akt/protein kinase B (Montrer AKT1 Anticorps) activity in a VEGF-C (Montrer VEGFC Anticorps)/VEGF receptor (Montrer FLT1 Anticorps) 3-independent manner during zebrafish embryogenesis.
Apelin knockdown inhibits both hypoxia-induced endothelial cell proliferation in vitro and hypoxia-induced vessel regeneration in the caudal (Montrer CAD Anticorps) fin regeneration of zebrafish.
the expression of APLNR (APJ/AGTRL1 (Montrer APLNR Anticorps)), the only known receptor for apelin, is predominantly restricted to the endothelial cells.
apelin effects on dynamic mechanical characteristics of single ventricular cardiomyocytes
Study shows that apelin-13 ameliorates chronic normobaric hypoxia-induced anxiety-like behavior in mice. Anxiolytic effects of apelin-13 might be associated with an inhibition of NF-kappaB (Montrer NFKB1 Anticorps) and microglial activation in the hippocampus.
Results revealed that apelin-13 attenuated brain edema and reduced cellular death by suppressing apoptosis after intracerebral hemorrhage in mice.
Apelin-36-[L28C(30kDa (Montrer TAF10 Anticorps)-PEG (Montrer PAEP Anticorps))] provides a starting point for the development of diabetes therapeutics that are devoid of the blood pressure effects associated with canonical APJ (Montrer APLNR Anticorps) activation
miR (Montrer MLXIP Anticorps)-503 promotes cardiac fibrosis via miR (Montrer MLXIP Anticorps)-503-Apelin-13-TGF-beta (Montrer TGFB1 Anticorps)-CTGF (Montrer CTGF Anticorps)-collagen production pathway.
Apelin directly interferes with thrombin-mediated signaling pathways and platelet activation, secretion, and aggregation, but not with ADP and thromboxane A2-mediated pathways.
Apelin regulates inflammatory response, diminishes inflammatory remote organ damage and improves survival in an experimental model of burn sepsis, which is at least partly mediated by a phosphatidylinositol 3-kinase/protein kinase B (Montrer AKT1 Anticorps) dependent pathway.
apelin is a potential activator of inflammation factors through the PI3K/Akt (Montrer AKT1 Anticorps) and Erk (Montrer EPHB2 Anticorps) signaling pathway and is potential therapeutically relevant to inflammatory responses of microglia cells
we showed the effect of Apelin on RAW264.7 macrophage under normal and hypoxic condition, which could further influence the angiogenesis and inflammation process that promoted by macrophages.
APJ receptor (Montrer APLNR Anticorps) in granulosa cells and both apelin and the APJ receptor (Montrer APLNR Anticorps) in theca tissues are expressed in bovine ovary.
The data suggest that apelin/APJ (Montrer APLNR Anticorps) system is involved in the mechanism regulating angiogenesis during follicle maturation as well as during corpora lutea formation and function in the bovine ovary.
these observations suggest apelin-APJ (Montrer APLNR Anticorps) signaling in hepatocytes functions to protect against lipid accumulation in liver through two signaling pathways, that is, via AMPK (Montrer PRKAA1 Anticorps) activation and PPARalpha (Montrer PPARA Anticorps) induction.
Studies suggest that apelin/APJ (Montrer APLNR Anticorps) system may be applied to the treatment of cancers by regulating apoptosis, which may play a vital role in anticancer therapy [review].
miR (Montrer MLXIP Anticorps)-497 contributes to oxLDL-induced lipid deposition in macrophages largely via targeting of apelin.
we have identified APLN as putative predictive bvz biomarker in CRC (Montrer CALR Anticorps) patients. High APLN levels predict a poor response to bvz therapy in CRC (Montrer CALR Anticorps).
Apelin-12 influences troponin I levels in the acute phase of STEMI, whereas during the non-acute phase, low apelin levels were associated with a high rate of MACE.
Apelin concentrations are associated with altered plaque stability mediator levels and atherosclerosis in patients with rheumatoid arthritis. These relations are partially dependent on population origin and systemic inflammatory status.
APLN and APLNR (Montrer APLNR Anticorps) are present in human ovarian cells and APLN increases IGF1 (Montrer IGF1 Anticorps)-induced steroidogenesis in granulosa cells through an increase in HSD3B (Montrer HSD3B1 Anticorps) protein expression and activation of the MAPK3 (Montrer MAPK3 Anticorps)/1 and Akt (Montrer AKT1 Anticorps) pathways. Therefore, APLN and APLNR (Montrer APLNR Anticorps) may play a role in human follicular development and the pathogenesis of PCOS.
Apelin levels mirror the cardiovascular changes seen in pregnancy. Serum and placental apelin levels are decreased in intrauterine growth restriction .
Reduced apelin levels may enhance vasoconstriction to influence high BP and heart's workload in EH and ACS.
Our data suggest that tumor Apelin can be used as a marker to evaluate clinical characteristics and predict prognosis in GC patients.
Apelin and its receptor (APJ (Montrer APLNR Anticorps)) appear to regulate ovarian follicular functions such as steroidogenesis and proliferation via APJ (Montrer APLNR Anticorps) activation and different signaling pathways.
Pig Apelin mRNA was sequenced.
This gene encodes a peptide that functions as an endogenous ligand for the G protein coupled receptor APJ. The encoded protein is synthesized as a prepropeptide that is processed into biologically active C-terminal fragments. The peptide fragments activate different tissue specific signaling pathways that regulate diverse biological functions including fluid homeostasis, cardiovascular function and insulin secretion. This protein also functions as a coreceptor for the human immunodeficiency virus 1.
, apelin, AGTRL1 ligand
, APJ endogenous ligand
, apelin; peptide ligand for APJ receptor
, AGTRL1 ligand