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anti-Human GABBR1 Anticorps:
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Mammalian Monoclonal GABBR1 Primary Antibody pour ISt, IHC - ABIN1304650
Karls, Mynlieff: GABAB receptors couple to Gαq to mediate increases in voltage-dependent calcium current during development. dans Journal of neurochemistry 2015
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Human Monoclonal GABBR1 Primary Antibody pour IF, RNAi - ABIN560976
Tse, Su, Chang, Tsang, Yu, Tang, See, Hsueh, Yang, Hao, Li, Wang, Liao, Chen, Lin, Jorgensen, Chang, Shugart: Genome-wide association study reveals multiple nasopharyngeal carcinoma-associated loci within the HLA region at chromosome 6p21.3. dans American journal of human genetics 2009
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Human Polyclonal GABBR1 Primary Antibody pour WB - ABIN152505
Fatemi, Folsom, Reutiman, Thuras: Expression of GABA(B) receptors is altered in brains of subjects with autism. dans Cerebellum (London, England) 2009
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Cow (Bovine) Polyclonal GABBR1 Primary Antibody pour WB - ABIN2473736
Bowery, Bettler, Froestl, Gallagher, Marshall, Raiteri, Bonner, Enna: International Union of Pharmacology. XXXIII. Mammalian gamma-aminobutyric acid(B) receptors: structure and function. dans Pharmacological reviews 2002
There was no statistically significant association for the two SNPs of the GABBR1 gene (rs29230 and rs29267). However, a significant difference between AUD individuals and controls was observed at genotype level for rs2900512 of GABBR2 (Montrer GABBR2 Anticorps) gene.
The combined analysis confirmed evidence of genome-wide significant associations in the Han Chinese population for three loci, at 2p16.1 (rs1051061, in an exon of VRK2, P=1.14 x 10-12, odds ratio (OR)=1.17), 6p22.1 (rs115070292 in an intron of GABBR1, P=4.96 x 10-10, OR=0.77) and 10q24.32 (rs10883795 in an intron of AS3MT, P=7.94 x 10-10, OR=0.87; rs10883765 at an intron of ARL3, P=3.06 x 10-9, OR=0.87).
Genotype and allele frequencies of rs29230 in GABR1 were significantly different between cases and controls, especially for male patients, for obstructive sleep apnea risk in Chinese Han population.
presynaptic gamma-aminobutyric acid type B receptor deficits contribute to altered neuronal excitability in fragile X (Montrer FMR1 Anticorps) syndrome
Results show that GABBR1 minor genotypes/alleles were protective against risk for alcoholism in 3 ethnically diverse cohorts.
Cell surface ubiquitination precedes endocytosis, after which USP14 acts as an ubiquitin-binding protein that targets the ubiquitinated GABA B receptor to lysosomal degradation and promotes its deubiquitination.
GABA(B)R stimulation promotes chemotaxis in RBL cells which is dependent on signaling via PI3-K/Akt, Src kinases and on rearrangement of both microtubules and actin cytoskeleton.
GABBR1 receptors are expressed in aortic smooth muscle cells and regulate the [Ca(2 (Montrer CA2 Anticorps)+)]i via a Gi/o-coupled receptor pathway and a phospholipase C (Montrer PLC Anticorps) activation pathway.
GABBR1 protein involved in phenylthiourea bitter taste detection.
Authors suggest GABBR1, GABA receptor B1, is implicated in schizophrenia based on a Human endogenous retrovirus long terminal repeat (HERV-W LTR) in the regulatory region of GABBR1.
These data suggest that GABA, acting through both presynaptic GABAA (Montrer GABRg1 Anticorps) and GABAB receptors, modulate the amplitude and short-term plasticity of excitatory synapses, a result not possible from activation of either receptor type alone
These results suggest a role for GABAB receptor in Fmrp (Montrer FMR1 Anticorps) regulation and a potential interest of GABAB receptor signaling in Fragile X (Montrer FMR1 Anticorps) syndrome improvement.
Activation of GABA(B) or mGlu2 (Montrer GRM2 Anticorps)/3 receptors inhibited both evoked presynaptic Ca(2 (Montrer CA2 Anticorps)+) transients and striatal field potentials.
Immunoblotting and RT-PCR results showed that NIHL increased the expression of PKCgamma (Montrer PRKCG Anticorps) but decreased that of GABABR1 and GABABR2 (Montrer GABBR2 Anticorps) at both protein and mRNA levels in the CNC
GABAB(1) receptor subunit isoforms differentially regulate the deleterious effects of stress and, thus, may be important therapeutic targets for the treatment of depression
Results establish an endogenous GABA/GABAB1 feedback mechanism that keeps TRPV1 (Montrer TRPV1 Anticorps)-mediated pain hypersensitivity in check.
The Gabbr1 has an important role in mediating the anxiety-related effects induced by nicotine.
Sex differences in reproductive genes Gnrh1 (Montrer GNRH1 Anticorps), Gad1 (Montrer GAD1 Anticorps), and Kiss1 (Montrer KISS1 Anticorps) are critically disturbed in GABAB1-deficient mice, probably altering the organization and development of neural circuits governing the reproductive axis.
GABAB signaling may normally directly or indirectly inhibit Kiss1 (Montrer KISS1 Anticorps) expression, particularly in the bed nucleus of the stria terminalis and medial amygdala
Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the mammalian central nervous system. GABA exerts its effects through ionotropic
, GABAB, subunit 1c
, gamma-aminobutyric acid type B receptor subunit 1
, seven transmembrane helix receptor
, gamma-aminobutyric acid (GABA) B receptor, 1
, gamma-aminobutyric acid (GABA) B receptor 1
, gamma-aminobutyric acid B receptor 1
, GABA-B receptor 1
, GABA-BR1b receptor
, bM573K1.1.1 (gamma-aminobutyric acid (GABA) B receptor, 1a)
, gamma-aminobutyric acid (GABA-B) receptor, 1