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Chicken Polyclonal GCG Primary Antibody pour IEM, ICC - ABIN617889
Pak, Cha, Rajotte, McArthur, Yoon: Human pancreatic islet cell specific 38 kilodalton autoantigen identified by cytomegalovirus-induced monoclonal islet cell autoantibody. dans Diabetologia 1991
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Human Monoclonal GCG Primary Antibody pour IHC (p) - ABIN3043073
Jiang, Deng, Duan, Chen, Xiang, Lu, Ma: Somatostatin receptors SSTR2 and SSTR5 are expressed in the human thoracic duct. dans Lymphology 2011
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Human Polyclonal GCG Primary Antibody pour IHC (p) - ABIN3042419
Chen, Yang, Zheng, Hu, Kong, Zhang: Effect of catch-up growth after food restriction on the entero-insular axis in rats. dans Nutrition & metabolism 2010
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Human Monoclonal GCG Primary Antibody pour CyTOF, FACS - ABIN4900763
Kornete, Beauchemin, Polychronakos, Piccirillo: Pancreatic islet cell phenotype and endocrine function throughout diabetes development in non-obese diabetic mice. dans Autoimmunity 2013
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Human Polyclonal GCG Primary Antibody pour ELISA, IF - ABIN2473808
Koistinaho, Hatanpää, Hervonen: Human paraganglion cells differentiate into adrenergic neurons in culture. dans Experimental neurology 1990
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Human Monoclonal GCG Primary Antibody pour ELISA, WB - ABIN966191
Geliebter, Hashim, Gluck: Appetite-related gut peptides, ghrelin, PYY, and GLP-1 in obese women with and without binge eating disorder (BED). dans Physiology & behavior 2008
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Human Polyclonal GCG Primary Antibody pour ELISA - ABIN2473805
Woods, Lutz, Geary, Langhans: Pancreatic signals controlling food intake; insulin, glucagon and amylin. dans Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2006
Human Polyclonal GCG Primary Antibody pour IF (p), IHC (p) - ABIN704246
Sun, Nie, Wang, Yang, Meng, Xiao, Xiang, Li, Fu, Wang: Factors that Affect Pancreatic Islet Cell Autophagy in Adult Rats: Evaluation of a Calorie-Restricted Diet and a High-Fat Diet. dans PLoS ONE 2016
Human Monoclonal GCG Primary Antibody pour ELISA, WB - ABIN969171
Arnés, González, Tornero-Esteban, Sancho, Acitores, Valverde, Delgado, Villanueva-Peñacarrillo: Characteristics of GLP-1 and exendins action upon glucose transport and metabolism in type 2 diabetic rat skeletal muscle. dans International journal of molecular medicine 2008
Human Polyclonal GCG Primary Antibody pour RIA - ABIN2473807
Figueroa, Hess, Ky, Brown, Sandig, Hermanowski-Vosatka, Twells, Todd, Austin: Expression of the type I diabetes-associated gene LRP5 in macrophages, vitamin A system cells, and the Islets of Langerhans suggests multiple potential roles in diabetes. dans The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2000
RYGB increased circulating bile acids, ileal Takeda G protein-coupled receptor 5 (Montrer XCR1 Anticorps) (TGR5 (Montrer GPBAR1 Anticorps)) and mTORC1 signaling activity, as well as GLP-1 production in both mice and human subjects. Inhibition of ileal mTORC1 signaling by rapamycin significantly attenuated the stimulation of bile acid secretion, TGR5 (Montrer GPBAR1 Anticorps) expression and GLP-1 synthesis induced by RYGB in lean and diet-induced obese mice.
Glucagon role in the pathophysiology of type 2 diabetes.[review]
This review summarizes the current knowledge regarding the role of GLP-1 in the protection against oxidative damage and the activation of the Nrf2 (Montrer GABPA Anticorps) signaling pathway. [review]
Study concludes that in healthy subjects, glucagon-like peptide-1 (GLP-1) increases cardiac output acutely due to a GLP-1-induced vasodilation in adipose tissue and skeletal muscle together with an increase in cardiac work.
Chenodeoxycholic acid stimulates glucagon-like peptide-1 secretion in patients after Roux-en-Y gastric bypass.
The results demonstrate that glucagon-like peptide-1 and insulin (Montrer INS Anticorps) synergistically and additively activate vagal afferent neurons.
DPP-4 (Montrer DPP4 Anticorps) activity and GLP (Montrer RCBTB1 Anticorps)-1total levels were higher in patients with microvascular complications associated with T2DM. Contrary to expectations, no negative correlation was seen between GLP-1 and DDP (Montrer TIMM8A Anticorps)-4 levels. This result suggests the possible inefficacy of DDP (Montrer TIMM8A Anticorps)-4 activity as a marker to predict in vivo degradation of endogenous GLP-1.
Data suggest that cAMP acts as amplifier of insulin (Montrer INS Anticorps) secretion triggered by Ca2 (Montrer CA2 Anticorps)+ elevation in beta-cells; both messengers are also positive modulators of glucagon release from alpha-cells, but in this case cAMP signaling may be the important regulator and Ca2 (Montrer CA2 Anticorps)+ signaling has a more permissive role. [REVIEW]
This study provides evidence that, in HepG2 cells, GLP-1 may affect cholesterol homeostasis by regulating the expression of miR (Montrer MLXIP Anticorps)-758 and ABCA1 (Montrer ABCA1 Anticorps).
This study reports the transition dipole strengths and frequencies of the amyloid beta-sheet amide I mode for the aggregated proteins amyloid-beta1-40, calcitonin (Montrer CALCA Anticorps), alpha-synuclein, and glucagon.
data show that the CREB (Montrer CREB1 Anticorps)/CRTC2 (Montrer CRTC2 Anticorps)-dependent transcriptional pathway is critical for regulating glucose homeostasis by controlling production of GLP-1 from the L cells at the level of transcription, maturation, and exocytosis.
the results of the present study indicated that GLP1 may be a promising target for the development of novel therapeutic strategies for HGinduced nephropathy, and may function through the activation of SIRT1 (Montrer SIRT1 Anticorps)
this study, we investigated whether glucagon and glucagon-like peptide-1 (GLP-1), hormones produced by alpha cells, contribute to insulin (Montrer INS Anticorps) secretion in INS-1 cells, a beta (Montrer SUCLA2 Anticorps) cell line. Co-treatment with glucagon and exendin-4 (Ex-4), a GLP-1 receptor (Montrer GLP1R Anticorps) agonist, additively increased glucose-stimulated insulin (Montrer INS Anticorps) secretion in INS-1 cells
FXR (Montrer NR1H4 Anticorps) exerts its function in L cells through interacting with CREB (Montrer CREB1 Anticorps), a crucial transcriptional regulator of cAMP-CREB (Montrer CREB1 Anticorps) signaling pathway, to inhibit its transcriptional activity. Targeting FXR (Montrer NR1H4 Anticorps) to rescue GLP-1 secretion may be a promising strategy for type II diabetes.
results show that glucagon controls gene expression and metabolic zonation in the liver through a counterplay with the Wnt (Montrer WNT2 Anticorps)/beta-catenin (Montrer CTNNB1 Anticorps) signaling pathway.
Data (including data from studies using transgenic and knockout mice) suggest that Glp1/Glp1r (Montrer GLP1R Anticorps) signaling in insulin (Montrer INS Anticorps)-secreting cells plays important role in development of glucose intolerance in obesity; however, Glp1r (Montrer GLP1R Anticorps) is not required in insulin (Montrer INS Anticorps)-secreting cells for improvement in glucose intolerance after weight loss due to bariatric surgery (here, vertical sleeve gastrectomy).
Chronic stress accelerates DPP4-mediated GLP-1 degradation and alters plasma adiponectin, accelerating vascular senescence and impairing ischemia-induced neovascularization.
Data suggest that metabolism of glutamine (Montrer GFPT1 Anticorps) and related analogs by Gdh (Montrer UGDH Anticorps) in intestinal L-cells explains why Glp1 secretion, but not that of insulin (Montrer INS Anticorps) by pancreatic beta-cells, is activated by these secretagogues. (Gdh (Montrer UGDH Anticorps) = glutamate (Montrer GRIN1 Anticorps) dehydrogenase; Glp1 = glucagon-like peptide 1)
Glucokinase (Montrer GCK Anticorps) governs an alpha-cell metabolic pathway that suppresses secretion at or above normoglycemic levels; abnormal suppression of glucagon secretion deregulates hepatic glucose metabolism and, over time, induces a pre-diabetic phenotype.
in colonic crypt cultures, the GLP-1 secretion induced by such Gq + Gs GPR40 (Montrer FFAR1 Anticorps) agonists is indeed inhibited by blockers of both Gq and Gs and is eliminated by combining these.
data demonstrate that cattle express proglucagon and glucagon-like peptide 2 receptor (Montrer GLP2R Anticorps) mRNA primarily in small intestinal and colon tissues and increased nutrient intake increases ileal proglucagon mRNA and plasma glucagon-like peptide 2
Data suggest that casein, safflower oil, sucrose, and sweetening agent rebaudioside A stimulate GLP1 release/secretion from enteroendocrine cells. (GLP1 = glucagon-like peptide 1, a peptide fragment derived from proglucagon)
The patterns of colocalization of the K cell marker, glucagon-like insulinotropic peptide, and L cell markers, glucagon like peptide-1 and peptide YY, in enteroendocrine cells of the small intestine and colon of mouse and pig, were investigated.
The findings indicate that the brainstem preproglucagon neuronal system is highly conserved between rat and non-human primate
The protein encoded by this gene is actually a preproprotein that is cleaved into four distinct mature peptides. One of these, glucagon, is a pancreatic hormone that counteracts the glucose-lowering action of insulin by stimulating glycogenolysis and gluconeogenesis. Glucagon is a ligand for a specific G-protein linked receptor whose signalling pathway controls cell proliferation. Two of the other peptides are secreted from gut endocrine cells and promote nutrient absorption through distinct mechanisms. Finally, the fourth peptide is similar to glicentin, an active enteroglucagon.
, glucagon-like peptide 1
, glucagon-like peptide 2
, glucagon-like peptide I
, glucagon-like peptide-1
, preproglucagon B
, glucagon preproprotein
, preproglucagon A
, glucagon I
, proglucagon I