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anti-Human RAD9A Anticorps:
anti-Mouse (Murine) RAD9A Anticorps:
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Human Monoclonal RAD9A Primary Antibody pour ICC, IF - ABIN266064
Shi, Chang, Cheng, Guan, Venclovas, Lu: Physical and functional interactions between MutY glycosylase homologue (MYH) and checkpoint proteins Rad9-Rad1-Hus1. dans The Biochemical journal 2006
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Human Monoclonal RAD9A Primary Antibody pour IF, IP - ABIN531964
Komatsu, Wharton, Hang, Wu, Singh, Lieberman, Pledger, Wang: PCNA interacts with hHus1/hRad9 in response to DNA damage and replication inhibition. dans Oncogene 2000
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Human Polyclonal RAD9A Primary Antibody pour IHC (p), WB - ABIN389631
Kelly, Davey: Tousled-like kinase-dependent phosphorylation of Rad9 plays a role in cell cycle progression and G2/M checkpoint exit. dans PLoS ONE 2013
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Polyclonal RAD9A Primary Antibody pour IHC (fro), WB - ABIN540317
Chen, Lin, Lieberman, Chen, Lee: ATM-dependent phosphorylation of human Rad9 is required for ionizing radiation-induced checkpoint activation. dans The Journal of biological chemistry 2001
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Human Polyclonal RAD9A Primary Antibody pour IHC (p), WB - ABIN389638
Xu, Vaithiyalingam, Glick, Mordes, Chazin, Cortez: The basic cleft of RPA70N binds multiple checkpoint proteins, including RAD9, to regulate ATR signaling. dans Molecular and cellular biology 2008
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Human Polyclonal RAD9A Primary Antibody pour ICC, IF - ABIN151428
Lieberman, Hopkins, Nass, Demetrick, Davey: A human homolog of the Schizosaccharomyces pombe rad9+ checkpoint control gene. dans Proceedings of the National Academy of Sciences of the United States of America 1997
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Yeast (Saccharomyces cerevisiae) Polyclonal RAD9A Primary Antibody pour ELISA, WB - ABIN2476309
Yamamoto, Tomita, Mikuni, Kobayashi, Kagaya, Katada, Ui, Takahashi: Direct activation of purified Go-type GTP binding protein by tricyclic antidepressants. dans Neuroscience letters 1992
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Human Polyclonal RAD9A Primary Antibody pour DB, IHC (p) - ABIN389633
Ronald, Awate, Rath, Carroll, Galiano, Dwyer, Kleiner-Hancock, Mathis, Vigod, De Benedetti: Phenothiazine Inhibitors of TLKs Affect Double-Strand Break Repair and DNA Damage Response Recovery and Potentiate Tumor Killing with Radiomimetic Therapy. dans Genes & cancer 2013
Human Polyclonal RAD9A Primary Antibody pour EIA, ELISA - ABIN188717
Brandt, Helt, Keng, Bambara: The Rad9 protein enhances survival and promotes DNA repair following exposure to ionizing radiation. dans Biochemical and biophysical research communications 2006
The authors show that human Cyclin (Montrer PCNA Anticorps)-Dependent-Kinases (CDKs) target the RAD9 subunit of the 9-1-1 checkpoint clamp (Montrer PDZK1 Anticorps) on Thr292, to modulate DNA damage checkpoint activation. Thr292 phosphorylation on RAD9 creates a binding site for Polo (Montrer PLK1 Anticorps)-Like-Kinase1 (PLK1 (Montrer PLK1 Anticorps)), which phosphorylates RAD9 on Thr313.
TLK1B mediated phosphorylation of Rad9 regulates its nuclear/cytoplasmic localization and cell cycle checkpoint
RAD9 has a prominent role in the ATR (Montrer ANTXR1 Anticorps)-Chk1 (Montrer CHEK1 Anticorps) pathway that is necessary for successful formation of the damage-sensing complex and DNA damage checkpoint signaling.
these results demonstrate a positive feedback loop involving Rad9A-dependend activation of Chk1 (Montrer CHEK1 Anticorps).
Intramolecular binding of the rad9 C-terminus in the checkpoint clamp (Montrer PDZK1 Anticorps) Rad9-Hus1 (Montrer HUS1 Anticorps)-Rad1 (Montrer ERCC4 Anticorps) is closely linked with its DNA binding.
The role of Rad9 in homologous recombination is independent of its function in checkpoint activation, and this function is important for preventing alternative non-homologous end joining.
we found that H1299 cells with reduced RAD9 protein levels showed a higher frequency of radiation induced bystander micronuclei formation
These data reveal that human Rad9 interacts directly with N-terminal region of human MYH (Montrer MUTYH Anticorps).
Downregulation of RAD9 when combined with ionizing radiation results in reduction of ITGB1 (Montrer ITGB1 Anticorps) protein levels in prostate cancer cells, and increased lethality.
Loss of hrad9 expression is associated with breast and lung cancer.
Rad9a is indispensable for spermatogonia differentiation and testicular development in mice.
RAD9 has a prominent role in the ATR (Montrer ATR Anticorps)-Chk1 (Montrer CHEK1 Anticorps) pathway that is necessary for successful formation of the damage-sensing complex and DNA damage checkpoint signaling.
We demonstrated that Mrad9 null enhances chromatid aberration frequency induced by radiation in bystander mouse embryonic stem cells
RAD9A is essential for male fertility and for repair of DNA double-strand breaks during meiotic prophase I.
HUS1 (Montrer HUS1 Anticorps) acts as a component of the canonical 9-1-1 complex during meiotic prophase I to promote DSB repair and further propose that RAD1 (Montrer RAD1 Anticorps) and TOPBP1 (Montrer TOPBP1 Anticorps) respond to unsynapsed chromatin through an alternative mechanism that does not require RAD9 or HUS1 (Montrer HUS1 Anticorps).
A review of the many activities assigned to Rad9, and speculation as to which influence its function in tumor development.
Data show that Rad9 plays dual roles in generating functional antibodies and in maintaining the integrity of the whole genome in B cells.
Rad9A-mediated Claspin (Montrer CLSPN Anticorps) localization is a vital step during checkpoint activation.
tousled-like kinases play important roles in DNA repair, not only by modulation of chromatin assembly via Asf1 (Montrer PEG3 Anticorps), but also by a more direct function in processing the ends of a tousled-like kinase via interaction with Rad9.
HRAD9 and Mrad9 are part of a gene family and reveal a new genetic element encoding a product that interacts with multiple, known cell cycle checkpoint control proteins.
MiR (Montrer MYLIP Anticorps)-2425-5p targets RAD9A and MYOG (Montrer MYOG Anticorps) to regulate the proliferation and differentiation of bovine skeletal muscle-derived satellite cells.
Data show that Rad17 (Montrer RAD17 Anticorps) mediates the interaction of the Rad9-Hus1 (Montrer HUS1 Anticorps)-Rad1 (Montrer ERCC4 Anticorps) (9-1-1) complex with the ATR (Montrer ATR Anticorps)-activating protein TopBP1 (Montrer TOPBP1 Anticorps) in Xenopus egg extracts.
interaction of the 9-1-1 complex (Rad9-Hus1-Rad1) with the BRCT I-II region of TopBP1 is necessary for binding of ATR-ATRIP to the ATR-activating domain of TopBP1 and the ensuing activation of ATR
TopBP1 (Montrer TOPBP1 Anticorps) and DNA polymerase-alpha directly recruit the 9-1-1 complex (rad9-rad1 (Montrer ERCC4 Anticorps)-Hus1 (Montrer HUS1 Anticorps)) to stalled DNA replication forks.
This gene product is highly similar to Schizosaccharomyces pombe rad9, a cell cycle checkpoint protein required for cell cycle arrest and DNA damage repair. This protein possesses 3' to 5' exonuclease activity, which may contribute to its role in sensing and repairing DNA damage. It forms a checkpoint protein complex with RAD1 and HUS1. This complex is recruited by checkpoint protein RAD17 to the sites of DNA damage, which is thought to be important for triggering the checkpoint-signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
DNA repair exonuclease rad9 homolog A
, cell cycle checkpoint control protein RAD9A
, RAD9 homolog A (S. pombe)
, cell cycle checkpoint control protein RAD9A-like
, Rad9-like protein
, RAD9 homolog A
, PCNA-like DNA checkpoint protein Rad9
, RAD9 checkpoint clamp component A L homeolog