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Mouse (Murine) Polyclonal CAD Primary Antibody pour ELISA, ICC - ABIN4286809
Hara, Miyake, Arakawa, Kamidono, Hara: Over expression of inhibitor of caspase 3 activated deoxyribonuclease in human renal cell carcinoma cells enhances their resistance to cytotoxic chemotherapy in vivo. dans The Journal of urology 2001
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Human Polyclonal CAD Primary Antibody pour ICC, IF - ABIN253268
Morin, Fritsch, Mathieu, Gilbert, Guarmit, Firlej, Gallou-Kabani, Vieillefond, Delongchamps, Cabon: Identification of CAD as an androgen receptor interactant and an early marker of prostate tumor recurrence. dans FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012
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structural evidences indicated that post-translational carbamylated Lys was not required for Znalpha binding in PaDHPase and in huDHOase.
The catalytic flexibile loop in the dihydrooratase domain possesses an absolutely conserved Phe-1563 residue required for catalytic activity.
CAD dihydroorotase and aspartate transcarbamoylase domains self-assembles into dimers and trimers.
Detection of the CAD-ALK gene fusion in urine tr-DNA anticipated radiological confirmation of disease progression. Analysis of plasma ctDNA identified ALK kinase mutations that emerged during treatment with the ALK inhibitor entrectinib
Charge neutralization in the active site of the catalytic trimer of aspartate transcarbamoylase promotes diverse structural changes.
This study showed that CAD deficiency co-occurrence of anaemia, anisopoikilocytosis, global developmental delay, and seizures.
Previous study found three metal ions in huDHOase active site; in the present study, the putative third metal binding site in type II enzymes, such as StDHOase and ScDHOase, was created and identified.
Changes in glycosylation in caused by mutations in CAD.
These results establish CAD as a downstream effector of Rheb and suggest a possible role of Rheb in regulating de novo pyrimidine nucleotide synthesis
Recombinant aspartate carbamoyltransferase domain from the CAD enzyme complex forms homotrimers in solution.
The results obtained indicate that mLST8 bridges between CAD and mTOR, and plays a role in the signaling mechanism where CAD is regulated in the mTOR pathway through the association with mLST8
preliminary X-ray diffraction analysis of the dihydroorotase domain of human CAD
findings show that in prostate tumor cells, CAD fosters androgen receptor translocation into the nucleus and stimulates its transcriptional activity; in radical prostatectomy specimens, CAD expression was not correlated with proliferation markers, but a higher CAD mRNA level was associated with local tumor extension and cancer relapse
the cad gene is regulated by a nonclassical ERalpha/Sp1-mediated pathway.
Data show that PRMT5 can be found in association with hSWI/SNF complexes and is involved in regulating the expression of carbamoyl-phosphate synthase-aspartate carbamoyltransferase-dihydroorotase.
the nuclear import of CAD appears to promote optimal cell growth
cad gene expression is repressed by hypoxia-inducible factor-1alpha, which represents a functional link between hypoxia and cell-cycle arrest.
hCPS_DeltaA was not able to fully assume the catalytically competent conformation, with specific activity of CP formation decreased 700-fold.
CAD functions as a necessary modulator of the hypertrophic response by regulating the mitogen-activated protein kinase-extracellular signal-regulated kinase 1/2 signaling pathway in the heart.
These findings suggest important posttranslational modifications requiring Cad as an unappreciated mechanism that regulates Notch/Vegf signaling during angiogenesis.
This study demonistrated that a novel role for carbamoyl phosphate synthetase 2 in cranial sensory circuit formation.
an essential role for CAD in facilitating proliferation and differentiation events in a tissue-specific manner
The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides.
, CAD trifunctional protein
, multifunctional protein CAD
, carbamyl phosphatate synthetase 2
, carbamoylphosphate synthetase 2/aspartate transcarbamylase/dihydroorotase
, carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
, CAD protein-like
, CAD protein carbamylphosphate synthetase domain
, dihydrorotate synthase