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CD27 expression is upregulated in a subset of hematopoietic cluster cells, and CD27 marks hematopoietic stem cells (HSC (Montrer FUT1 Protéines)), type II pre-HSCs, and progenitors with lymphoid potential within the cluster cells.
CD70 (Montrer CD70 Protéines) reverse signaling enhances NK cell function and immunosurveillance in CD27-expressing B-cell malignancies.
CD27-dependent CD8 (Montrer CD8A Protéines)(+) T cell priming and differentiation are shaped by the efficiency of NK responses to virus infection.
HSCs appear to maintain expression of CD27 after hematopoietic injury when Kit expression is downregulated.
Mature CD27low NK cells promote allograft survival under costimulatory blockade conditions by regulating alloreactive memory CD8+ T-cell responses in T-bet dependent manner.
identify an IL-17 (Montrer IL17A Protéines)-dependent lymphoid/myeloid cross-talk involving CD27(-) gammadelta T cells and small peritoneal macrophages that promotes ovarian tumor cell growth and thus counteracts cancer immunosurveillance
memory CD8 (Montrer CD8A Protéines) T cells, generated through priming with CD27 agonists, proliferated more extensively than did 4-1BB (Montrer TNFRSF9 Protéines)-generated memory cells, but these cells failed to persist.
the central role played by CD27/70 during secondary CD8 (Montrer CD8A Protéines)(+) T-cell activation to a peptide Ag, and identify sCD70 as an immunotherapeutic adjuvant for antitumor immunity.
under conditions of constitutive CD70 (Montrer CD70 Protéines) expression reflecting chronic immune activation, the CD27/CD70 (Montrer CD70 Protéines) system inhibits OC differentiation and favors DC differentiation
mTECs and DCs form dedicated niches in the thymic medulla, in which CD27-CD70 (Montrer CD70 Protéines) co-stimulation rescues developing Treg cells from apoptosis, subsequent to Foxp3 (Montrer FOXP3 Protéines) induction by TCR and CD28 (Montrer CD28 Protéines) signals.
Results suggests that CD27 could be a marker for poor prognosis for non-ETV6 (Montrer ETV6 Protéines)-RUNX1 (Montrer RUNX1 Protéines) B-cell precursor acute lymphoblastic leukemia.
The authors observed differential expression of CD95(Fas (Montrer FAS Protéines)) in CD27(+) B-cells from cirrhotic patients that was inversely correlated with peripheral CD27(+) B-cell frequency. They conclude that peripheral CD27(+) memory B-cells in cirrhosis exhibit increased sensitivity to Fas (Montrer FAS Protéines)-induced apoptosis in an activation-dependent manner to which endotoxin contributes, associated with reduced frequency of circulating memory B-cells.
Preclinical testing supports the safety and efficacy of a CD27-containing CAR targeting CD70 (Montrer CD70 Protéines)-expressing tumors
Crystal structure of CD27 in complex with a neutralizing noncompeting antibody has been reported.
High CD27 expression is associated with B-cell Lymphoma.
activated CD70 (Montrer CD70 Protéines)-expressing lymphocytes may trigger CD27 on AML (Montrer RUNX1 Protéines) blasts or stem/progenitor cells
the CD70 (Montrer CD70 Protéines)-CD27 pathway appears to be a crucial component of EBV-specific T cell immunity and more generally for the immune surveillance of B cells and may be a target for immunotherapy of B cell malignancies.
This study demonstrates increased level of sCD27 in patients with active vitiligo (Montrer MITF Protéines).
This study demonstrated that Soluble CD27 in cerebrospinal fluid of patients with Clinically Isolated Syndrome was associated with multiple sclerosis diagnosis and a high relapse rate.
HCV infection increased the frequency of CD4 (Montrer CD4 Protéines)+CXCR5 (Montrer CXCR5 Protéines)+ T cells and decreased the frequency of CD27+IgG+ B cells. CD4 (Montrer CD4 Protéines)+CXCR5 (Montrer CXCR5 Protéines)+ T cells activated CD27+IgG+ B cells via the secretion of IL-21 (Montrer IL17C Protéines).
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor.
tumor necrosis factor receptor superfamily, member 7
, CD27 antigen
, CD27L receptor
, CD antigen 27
, T-cell activation antigen CD27
, tumor necrosis factor receptor superfamily member 7
, T cell activation antigen S152