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PNUTS is a bifunctional RNA encoding both PNUTS mRNA and lncRNA-PNUTS, each eliciting distinct biological functions. While PNUTS mRNA is ubiquitously expressed, lncRNA-PNUTS appears to be tightly regulated dependent on the status of hnRNP E1 (Montrer PCBP1 Kits ELISA) and tumour context.
Biophysical analysis of PNUTS suggests an extended transcription factor TFIIS (Montrer TCEA1 Kits ELISA)-like fold.
PNUTS was a valid target of miR (Montrer MLXIP Kits ELISA)-383 and was involved in the inhibition of gammaH2AX (Montrer H2AFX Kits ELISA).
PNUTS inhibits the PP1-mediated dephosphorylation of critical substrates, especially retinoblastoma protein, by blocking their binding sites on PP1.
our studies reveal PNUTS as a novel PTEN regulator and a likely oncogene (Montrer RAB1A Kits ELISA).
PNUTS is identified as a new and integral component of the DNA damage response involved in DNA repair.
stimulation of PP1 (Montrer PPA1 Kits ELISA) activity via siRNA mediated knockdown of its interacting protein PNUTS (Phosphatase Nuclear Targeting Subunit) leads to Rb dephosphorylation and apoptosis in cancer cells
mammalian Wdr82 functions in a variety of cellular processes; PTW/PP1 phosphatase complex (PNUTS, Tox4, Wdr82, PP1) has a role in the regulation of chromatin structure during the transition from mitosis into interphase
PNUTS has a role in protein kinase A-regulated targeting of PP1 to specific RNA-associated complexes in the nucleus
PNUTS, encoded by CAT 53 on 6p21.3, may have a role in the progression of AD.
stimulation of PP1 (Montrer PPP1CC Kits ELISA) activity via siRNA mediated knockdown of its interacting protein PNUTS (Phosphatase Nuclear Targeting Subunit) leads to Rb dephosphorylation and apoptosis in cancer cells
Protein phosphatase 1 (Montrer PPP1CB Kits ELISA) (PP1 (Montrer PPP1CC Kits ELISA)) and GABA(C (Montrer GABRR1 Kits ELISA)) receptors simultaneously bind to different domains of PNUTS, demonstrating that PNUTS crosslinks PP1 (Montrer PPP1CC Kits ELISA) and GABA(C (Montrer GABRR1 Kits ELISA)) receptors.
This gene encodes a protein phosphatase 1 binding protein. The encoded protein plays a role in many cellular processes including cell cycle progression, DNA repair and apoptosis by regulating the activity of protein phosphatase 1. This gene lies within the major histocompatibility complex class I region on chromosome 6, and alternatively spliced transcript variants have been observed for this gene.
HLA-C associated transcript 53
, MHC class I region proline-rich protein CAT53
, PP1-binding protein of 114 kDa
, phosphatase 1 nuclear targeting subunit
, protein phosphatase 1, regulatory (inhibitor) subunit 10
, serine/threonine-protein phosphatase 1 regulatory subunit 10
, HLA-C adjacent transcript 53
, protein phosphatase I
, putative protein phosphatase 1 nuclear targeting subunit