anti-Rat (Rattus) SIX3 anticorps pour ELISA

Recommended SIX3 Antibody (fourni par: Connectez-vous pour afficher )

Antigène
Sine Oculis-Related Homeobox 3 (SIX3) Anticorps
  • HPE2
  • SIX3
  • cb347
  • six3.2
  • six6
  • E130112M24Rik
  • Six3a
  • Six3alpha
  • Six3b
  • Six3beta
  • SIX homeobox 3
  • SIX homeobox 3b
  • sine oculis-related homeobox 3
  • sine oculis homeobox homolog 3
  • SIX3
  • six3b
  • Six3
  • six3
Reactivité
Humain, Souris, Rat (Rattus)
67
36
28
19
3
3
2
2
2
Hôte
Lapin
61
15
10
2
Clonalité
Polyclonal
Conjugué
Cet anticorp SIX3 est non-conjugé
4
4
4
3
3
3
1
1
1
1
1
1
1
1
1
1
1
Application
ELISA, Immunohistochemistry (IHC), Western Blotting (WB)
60
43
13
5
5
5
4
1
1
Fournisseur
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N° du produit (Fournisseur)
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N° du produit ABIN6265097
$ 390.77
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General

Antigène Sine Oculis-Related Homeobox 3 (SIX3) Anticorps
Reactivité Humain, Souris, Rat (Rattus)
(67), (36), (28), (19), (3), (3), (2), (2), (2)
Hôte Lapin
(61), (15), (10), (2)
Clonalité
Polyclonal
Conjugué Cet anticorp SIX3 est non-conjugé
(4), (4), (4), (3), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application ELISA, Immunohistochemistry (IHC), Western Blotting (WB)
(60), (43), (13), (5), (5), (5), (4), (1), (1)
Fournisseur Connectez-vous pour afficher

Détail du produit anti-SIX3 anticorps

Détail du antigène SIX3 Information d'application Stockage Images
Specificité SIX3 Antibody detects endogenous levels of total SIX3
 Réactivité croisée Humain, Souris, Rat (Rattus)
Purification The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
Immunogène A synthesized peptide derived from human SIX3
Isotype IgG
Plasmids, Primers & others

Détail du antigène SIX3

Détail du produit anti-SIX3 anticorps Information d'application Stockage Images Haut de la page
Antigène
Autre désignation SIX3 (SIX3 Antibody Extrait)
Sujet

Description: Transcriptional regulator which can act as both a transcriptional repressor and activator by binding a ATTA homeodomain core recognition sequence on these target genes. During forebrain development represses WNT1 expression allowing zona limitans intrathalamica formation and thereby ensuring proper anterio-posterior patterning of the diencephalon and formation of the rostral diencephalon. Acts as a direct upstream activator of SHH expression in the rostral diencephalon ventral midline and that in turn SHH maintains its expression. In addition, Six3 activity is required for the formation of the telencephalon. During postnatal stages of brain development is necessary for ependymal cell maturation by promoting the maturation of radial glia into ependymal cells through regulation of neuroblast proliferation and migration. Acts on the proliferation and differentiation of neural progenitor cells through activating transcription of CCND1 AND CCND2. During early lens formation plays a role in lens induction and specification by activating directly PAX6 in the presumptive lens ectoderm. In turn PAX6 activates SIX3 resulting in activation of PDGFRA and CCND1 promoting cell proliferation. Also is required for the neuroretina development by directly suppressing WNT8B expression in the anterior neural plate territory. Its action during retina development and lens morphogenesis is AES and TLE4-dependent manner. Furthermore, during eye development regulates several genes expression. Before and during early lens development represses the CRYGF promoter by binding a SIX repressor element. Directly activates RHO transcription, or cooperates with CRX or NRL. Six3 functions also in the formation of the proximodistal axis of the optic cup, and promotes the formation of optic vesicles-like structures. During pituitary development, acts in parallel or alternatively with HESX1 to control cell proliferation through Wnt/beta-catenin pathway (By similarity). Plays a role in eye development by suppressing WNT1 expression and in dorsal-ventral patterning by repressing BMP signaling pathway.

Gene: SIX3

Poids moléculaire 35 kDa
ID gène 6496
UniProt O95343
Pathways Protein targeting to Nucleus

Information d'application

Détail du produit anti-SIX3 anticorps Détail du antigène SIX3 Stockage Images Haut de la page
Indications d'application WB 1:1000-3000 IHC 1:200
Restrictions For Research Use only

Stockage

Détail du produit anti-SIX3 anticorps Détail du antigène SIX3 Information d'application Images Haut de la page
Format Liquid
Concentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock -20 °C
Stockage commentaire Store at -20 °C.Stable for 12 months from date of receipt
Date de péremption 12 months

Images

Détail du produit anti-SIX3 anticorps Détail du antigène SIX3 Information d'application Stockage Haut de la page
Images (Fournisseur)
Western Blotting (WB) image for anti-Sine Oculis-Related Homeobox 3 (SIX3) antibody (ABIN6265097) Western blot analysis SIX3 using A549 whole cell lysates
Immunohistochemistry (IHC) image for anti-Sine Oculis-Related Homeobox 3 (SIX3) antibody (ABIN6265097) ABIN6279503 at 1/100 staining Mouse kidney tissue by IHC-P. The sample was formaldehy...