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Combining these results with small-angle X-ray scattering data for the complex of TRN-SR2 with truncated integrase, we propose a molecular model of the complex. We speculate that nuclear import of the PIC may proceed concurrently with the normal nuclear transport.
IRF5 (Montrer IRF5 Protéines)-TNPO3 genetic variation is associated systemic lupus erythematosus.
Data suggest that the HIV-1 integrase (IN)/transportin-SR2 (TRN-SR2) interaction interface is a potential target for antiviral therapy.
Tnpo3 mutants that are not able to interact with cleavage and polyadenylation specificity factor 6 (Montrer CPSF6 Protéines) do not facilitate HIV-1 infectivity, suggesting a potential route of pharmacological intervention in the treatment of AIDS.
In skeletal muscle of limb-girdle muscular dystrophy 1F individuals, expression of transportin 3 indicates altered transportin 3 function.
The TNPO3 gene is mapped within the Limb-girdle muscular dystrophy 1F critical interval and its 923-amino acid human gene product is also expressed in skeletal muscle.
a model wherein one monomer of TRN-SR2 is bound to one monomer of RanGTP.
These results suggested that inhibition of HIV-1 by TNPO3-depleted cells requires CPSF6 (Montrer CPSF6 Protéines).
TNPO3 promotes HIV-1 infectivity indirectly, by shifting the CA-binding protein CPSF6 (Montrer CPSF6 Protéines) to the nucleus, thus preventing the excessive HIV-1 CA stability that would otherwise result from cytoplasmic accumulation of CPSF6 (Montrer CPSF6 Protéines).
These results suggest that TNPO3 and cyclophilin A (Montrer PPIA Protéines) facilitate HIV-1 infection by coordinating proper uncoating of the core in target cells.
The protein encoded by this gene is a nuclear import receptor for serine/arginine-rich (SR) proteins such as the splicing factors SFRS1 and SFRS2. The encoded protein has also been shown to be involved in HIV-1 infection, apparently through interaction with the HIV-1 capsid protein. Two transcript variants encoding different isoforms as well as a noncoding transcript have been found for this gene.
, transportin 3
, importin 12