IGF2R Protein (AA 2328-2491, partial) (GST tag)

N° du produit ABIN1046788

Détail du produit

Antigène: IGF2R (Insulin-Like Growth Factor 2 Receptor (IGF2R))

Type de proteíne: Recombinant

Attributs du protein: AA 2328-2491, partial

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette IGF2R protéine est marqué à la GST tag.

Application: ELISA

Séquence: KKERRETVIS KLTTCCRRSS NVSYKYSKVN KEEETDENET EWLMEEIQLP PPRQGKEGQE NGHITTKSVK ALSSLHGDDQ DSEDEVLTIP EVKVHSGRGA GAESSHPVRN AQSNALQERE DDRVGLVRGE KARKGKSSSA QQKTVSSTKL VSFHDDSDED LLHI

Attributs du produit: Please inquire if you are interested in this recombinant protein expressed in E. coli, mammalien cells or by baculovirus infection. Be aware about differences in price and lead time.

Pureté: 90 %

Information d'application

Commentaires:

The yeast protein expression system is the most economical and efficient eukaryotic system for secretion and intracellular expression. A protein expressed by the mammalian cell system is of very high-quality and close to the natural protein. But the low expression level, the high cost of medium and the culture conditions restrict the promotion of mammalian cell expression systems. The yeast protein expression system serve as a eukaryotic system integrate the advantages of the mammalian cell expression system. A protein expressed by yeast system could be modificated such as glycosylation, acylation, phosphorylation and so on to ensure the native protein conformation. It can be used to produce protein material with high added value that is very close to the natural protein. Our proteins produced by yeast expression system has been used as raw materials for downstream preparation of monoclonal antibodies.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Concentration: 0.2-2 mg/mL

Buffer: Tris-based buffer, 50 % glycerol

Conseil sur la manipulation: Repeated freezing and thawing is not recommended. Store working aliquots at 4 °C for up to one week

Stock: -20 °C

Stockage commentaire: Store at -20 °C for extended storage, conserve at -20 °C or -80 °C

Référence

Killian, Jirtle: "Genomic structure of the human M6P/IGF2 receptor." dans: Mammalian genome : official journal of the International Mammalian Genome Society, Vol. 10, Issue 1, pp. 74-7, (1999) (PubMed).

Oshima, Nolan, Kyle, Grubb, Sly: "The human cation-independent mannose 6-phosphate receptor. Cloning and sequence of the full-length cDNA and expression of functional receptor in COS cells." dans: The Journal of biological chemistry, Vol. 263, Issue 5, pp. 2553-62, (1988) (PubMed).

Morgan, Edman, Standring, Fried, Smith, Roth, Rutter: "Insulin-like growth factor II receptor as a multifunctional binding protein." dans: Nature, Vol. 329, Issue 6137, pp. 301-7, (1987) (PubMed).

Détail du antigène

Antigène: IGF2R (Insulin-Like Growth Factor 2 Receptor (IGF2R))

Autre désignation: Cation-independent mannose-6-phosphate receptor protein (IGF2R Produits)

Synonymes: CD222 Protein, CIMPR Protein, M6P-R Protein, MPR1 Protein, MPRI Protein, AI661837 Protein, CI-MPR Protein, M6P/IGF2R Protein, Mpr300 Protein, mpri Protein, cd222 Protein, cimpr Protein, m6p-r Protein, insulin like growth factor 2 receptor Protein, insulin-like growth factor 2 receptor Protein, IGF2R Protein, Igf2r Protein, igf2r Protein

Sujet: Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4.

Poids moléculaire: 45.7 kD

UniProt: P20645