HNRNPD/AUF1 Protein (AA 18-355, partial) (GST tag)

N° du produit ABIN1047165

Détail du produit

Antigène: HNRNPD/AUF1 (HNRNPD) (Heterogeneous Nuclear Ribonucleoprotein D (HNRNPD))

Type de proteíne: Recombinant

Attributs du protein: AA 18-355, partial

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette HNRNPD/AUF1 protéine est marqué à la GST tag.

Application: SDS-PAGE (SDS), ELISA

Séquence: AVGGSAGEQE GAMVAATQGA AAAAGSGAGT GGGTASGGTE GGSAESEGAK IDASKNEEDE GHSNSSPRHS EAATAQREEW KMFIGGLSWD TTKKDLKDYF SKFGEVVDCT LKLDPITGRS RGFGFVLFKE SESVDKVMDQ KEHKLNGKVI DPKRAKAMKT KEPVKKIFVG GLSPDTPEEK IREYFGGFGE VESIELPMDN KTNKRRGFCF ITFKEEEPVK KIMEKKYHNV GLSKCEIKVA MSKEQYQQQQ QWGSRGGFAG RARGRGGDQQ SGYGKVSRRG GHQNSYKPY

Attributs du produit: Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Also binds to double- and single-stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5'-UUAG-3' sequence and also weaker to the single-stranded 5'-TTAGGG-3' telomeric DNA repeat. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. Binding of RRM1 to DNA inhibits the formation of DNA quadruplex structure which may play a role in telomere elongation. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Ref.13 Ref.30

Pureté: 90 %

Information d'application

Commentaires:

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: PBS buffer, 20mM GSH

Stock: -20 °C

Référence

Ota, Suzuki, Nishikawa, Otsuki, Sugiyama, Irie, Wakamatsu, Hayashi, Sato, Nagai, Kimura, Makita, Sekine, Obayashi, Nishi, Shibahara, Tanaka, Ishii, Yamamoto, Saito, Kawai, Isono, Nakamura, Nagahari et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs. ..." dans: Nature genetics, Vol. 36, Issue 1, pp. 40-5, (2003) (PubMed).

Dempsey, Li, DePace, Bray-Ward, Maizels: "The human HNRPD locus maps to 4q21 and encodes a highly conserved protein." dans: Genomics, Vol. 49, Issue 3, pp. 378-84, (1998) (PubMed).

Kajita, Nakayama, Aizawa, Ishikawa: "The UUAG-specific RNA binding protein, heterogeneous nuclear ribonucleoprotein D0. Common modular structure and binding properties of the 2xRBD-Gly family." dans: The Journal of biological chemistry, Vol. 270, Issue 38, pp. 22167-75, (1995) (PubMed).

Détail du antigène

Antigène: HNRNPD/AUF1 (HNRNPD) (Heterogeneous Nuclear Ribonucleoprotein D (HNRNPD))

Autre désignation: Heterogeneous nuclear ribonucleoprotein D0 (HNRNPD Produits)

Synonymes: AUF1 Protein, AUF1A Protein, HNRPD Protein, P37 Protein, hnRNPD0 Protein, Auf1 Protein, Hnrnpd Protein, HNRNPD Protein, p37 Protein, auf1a Protein, hnrpd Protein, hnrnpd0 Protein, C230004L04 Protein, Hnrpd Protein, wu:fa28b06 Protein, zgc:162951 Protein, heterogeneous nuclear ribonucleoprotein D Protein, heterogeneous nuclear ribonucleoprotein D L homeolog Protein, HNRNPD Protein, Hnrnpd Protein, hnrnpd Protein, hnrnpd.L Protein

Sujet: Synonyms: AU-rich element RNA-binding protein 1

Poids moléculaire: 58.6 kD

UniProt: Q14103