PRMT1 Protein (AA 1-248, partial) (GST tag)

N° du produit ABIN1047576

Détail du produit

Antigène: PRMT1 (Protein Arginine Methyltransferase 1 (PRMT1))

Type de proteíne: Recombinant

Attributs du protein: AA 1-248, partial

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette PRMT1 protéine est marqué à la GST tag.

Application: SDS-PAGE (SDS), ELISA

Séquence: MAAAEAANCI MENFVATLAN GMSLQPPLEE VSCGQAESSE KPNAEDMTSK DYYFDSYAHF GIHEEMLKDE VRTLTYRNSM FHNRHLFKDK VVLDVGSGTG ILCMFAAKAG ARKVIGIECS SISDYAVKIV KANKLDHVVT IIKGKVEEVE LPVEKVDIII SEWMGYCLFY ESMLNTVLYA RDKWLAPDGL IFPDRATLYV TAIEDRQYKD YKIHWWENVY GFDMSCIKDV AIKEPLVDVV DPKQLVTN

Attributs du produit: Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, PIAS1, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15 and EWS. Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 'Arg-4' (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation. Together with dimethylated PIAS1, represses STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway. Ref.9 Ref.10 Ref.11 Ref.13 Ref.14 Ref.15 Ref.16 Ref.17 Ref.18 Ref.19

Pureté: 90 %

Information d'application

Commentaires:

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 6M guanidine hydrochloride, 20mM Tris

Stock: -20 °C

Référence

Scorilas, Black, Talieri, Diamandis: "Genomic organization, physical mapping, and expression analysis of the human protein arginine methyltransferase 1 gene." dans: Biochemical and biophysical research communications, Vol. 278, Issue 2, pp. 349-59, (2000) (PubMed).

Scott, Antonarakis, Lalioti, Rossier, Silver, Henry: "Identification and characterization of two putative human arginine methyltransferases (HRMT1L1 and HRMT1L2)." dans: Genomics, Vol. 48, Issue 3, pp. 330-40, (1998) (PubMed).

Détail du antigène

Antigène: PRMT1 (Protein Arginine Methyltransferase 1 (PRMT1))

Autre désignation: Protein arginine N-methyltransferase 1 (PRMT1 Produits)

Sujet: Synonyms: Histone-arginine N-methyltransferase PRMT1,Interferon receptor 1-bound protein 4

Poids moléculaire: 55.4 kD

UniProt: Q99873