CES1 Protein (AA 19-562) (His tag)

N° du produit ABIN1096215

Détail du produit

Antigène: CES1 (Carboxylesterase 1 (CES1))

Type de proteíne: Recombinant

Attributs du protein: AA 19-562

Origine: Humain

Source: Human Cells

Purification/Conjugué: Cette CES1 protéine est marqué à la His tag.

Fonction: Recombinant Human Carboxylesterase 1/CES1 (C-6His)

Séquence: HPSSPPVVDT VHGKVLGKFV SLEGFAQPVA IFLGIPFAKP PLGPLRFTPP QPAEPWSFVK NATSYPPMCT QDPKAGQLLS ELFTNRKENI PLKLSEDCLY LNIYTPADLT KKNRLPVMVW IHGGGLMVGA ASTYDGLALA AHENVVVVTI QYRLGIWGFF STGDEHSRGN WGHLDQVAAL RWVQDNIASF GGNPGSVTIF GESAGGESVS VLVLSPLAKN LFHRAISESG VALTSVLVKK GDVKPLAEQI AITAGCKTTT SAVMVHCLRQ KTEEELLETT LKMKFLSLDL QGDPRESQPL LGTVIDGMLL LKTPEELQAE RNFHTVPYMV GINKQEFGWL IPMLMSYPLS EGQLDQKTAM SLLWKSYPLV CIAKELIPEA TEKYLGGTDD TVKKKDLFLD LIADVMFGVP SVIVARNHRD AGAPTYMYEF QYRPSFSSDM KPKTVIGDHG DELFSVFGAP FLKEGASEEE IRLSKMVMKF WANFARNGNP NGEGLPHWPE YNQKEGYLQI GANTQAAQKL KDKEVAFWTN LFAKKAVEKP PQTEVDHHHH HH

Attributs du produit: Recombinant Human Carboxylesterase 1/CES1 is produced with our mammalian expression system in human cells. The target protein is expressed with sequence (His19-Glu562) of Human CES1 fused with a polyhistidine tag at the C-terminus.

Pureté: > 95 % as determined by reducing SDS-PAGE.

Stérilité: 0.2 μm filtered

niveau d'endotoxine: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Reconstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM HAc-NaAc, 150 mM NaCl, pH 4.0.

Conseil sur la manipulation: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Stock: -80 °C

Stockage commentaire: Store at < -20°C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles.

Date de péremption: 6 months

Détail du antigène

Antigène: CES1 (Carboxylesterase 1 (CES1))

Autre désignation: ces1 (CES1 Produits)

Synonymes: ACAT Protein, CE-1 Protein, CEH Protein, CES2 Protein, HMSE Protein, HMSE1 Protein, PCE-1 Protein, REH Protein, SES1 Protein, TGH Protein, hCE-1 Protein, CESDD1 Protein, CES1 Protein, CES-K1 Protein, APLE Protein, PMPMEase Protein, CES Protein, carboxylesterase 1 Protein, liver carboxylesterase 1 Protein, liver carboxylesterase Protein, carboxylesterase 1 (monocyte/macrophage serine esterase 1) Protein, CES1 Protein, CpipJ_CPIJ013026 Protein, CpipJ_CPIJ016339 Protein, LOC100009551 Protein, LOC454097 Protein, LOC699486 Protein, LOC100050915 Protein

Sub Type: Fusionprotein

Sujet: Carboxylesterase 1 (CES1) is a member of a large family of carboxylesterases that are responsible for the hydrolysis of ester and amide bonds. These enzymes have broad substrate specificity ranging from small molecule esters such as phenylester to long chain fatty acid esters and thioesters. They are major determinants of the pharmacokinetic behavior of most therapeutic agents containing an ester or amide bond. CES1 shares the serine hydrolase fold observed in other esterases. CES1 hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl-CoA ester. CES1 participates in detoxification of drugs such as cocaine and heroin in serum and liver. It may also play a role in detoxification in the lung and/or protection of the central nervous system from ester or amide compounds.
Alternative Names: Liver Carboxylesterase 1, Acyl-Coenzyme A:Cholesterol Acyltransferase, ACAT, Brain Carboxylesterase hBr1, Carboxylesterase 1, CE-1, hCE-1, Cocaine Carboxylesterase, Egasyn, HMSE, Methylumbelliferyl-Acetate Deacetylase 1, Monocyte/Macrophage Serine Esteras

Poids moléculaire: 61.05 kDa

Pathways: Monocarboxylic Acid Catabolic Process