GNMT Protein (AA 2-294) (His tag)

N° du produit ABIN1096756

Détail du produit

Antigène: GNMT (Glycine N-Methyltransferase (GNMT))

Type de proteíne: Recombinant

Attributs du protein: AA 2-294

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette GNMT protéine est marqué à la His tag.

Fonction: Recombinant Human Glycine N-Methyltransferase/GNMT (N-6His)

Séquence: MGSSHHHHHH SSGLVPRGSH MVDSVYRTRS LGVAAEGLPD QYADGEAARV WQLYIGDTRS RTAEYKAWLL GLLRQHGCQR VLDVACGTGV DSIMLVEEGF SVTSVDASDK MLKYALKERW NRRHEPAFDK WVIEEANWMT LDKDVPQSAE GGFDAVICLG NSFAHLPDCK GDQSEHRLAL KNIASMVRAG GLLVIDHRNY DHILSTGCAP PGKNIYYKSD LTKDVTTSVL IVNNKAHMVT LDYTVQVPGA GQDGSPGLSK FRLSYYPHCL ASFTELLQAA FGGKCQHSVL GDFKPYKPGQ TYIPCYFIHV LKRTD

Attributs du produit: Recombinant Human Glycine N-Methyltransferase/GNMT is produced by our E. coli expression system. The target protein is expressed with sequence (Val2-Asg294) of Human GNMT fused with a 6His tag at the N-terminus.

Pureté: > 95 % as determined by reducing SDS-PAGE.

Stérilité: 0.2 μm filtered

niveau d'endotoxine: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Reconstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM TrisHCl, 150 mM NaCl, pH 8.0.

Conseil sur la manipulation: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Stock: -80 °C

Stockage commentaire: Store at < -20°C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles.

Date de péremption: 6 months

Détail du antigène

Antigène: GNMT (Glycine N-Methyltransferase (GNMT))

Autre désignation: Glycine-N-methyltransferase (GNMT Produits)

Synonymes: glycine N-methyltransferase Protein, CpipJ_CPIJ015956 Protein, Gnmt Protein, GNMT Protein

Sub Type: Fusionprotein

Sujet: Glycine N-Methyltransferase (GNMT) is a tetrameric cytosolic protein. GNMT catalyzes the synthesis of N-methylglycine from glycine using S-adenosylmethionine (AdoMet) as the methyl donor. It can affects DNA methylation by regulating the ratio of S-adenosylmethionine to S-adenosylhomocystine, playing an important role in maintaining normal AdoMet levels. GNMT is highly expressed in liver. As a major folate-binding protein, GNMT takes part in the detoxification pathway. Defects in GNMT are the cause of hypermethioninemia. the patients with this deficiency are mild hepatomegaly and chronic elevation of serum transaminases.
Alternative Names: Glycine N-Methyltransferase, GNMT

Poids moléculaire: 34.9 kDa

UniProt: Q14749

Pathways: Cellular Glucan Metabolic Process, Regulation of Carbohydrate Metabolic Process