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GRB2 Protein (AA 1-217) (His tag)

GRB2 Origine: Humain Hôte: Escherichia coli (E. coli) Recombinant > 95 % as determined by reducing SDS-PAGE.
N° du produit ABIN1096789
  • Antigène Voir toutes GRB2 Protéines
    GRB2 (Growth Factor Receptor-Bound Protein 2 (GRB2))
    Type de proteíne
    Recombinant
    Attributs du protein
    AA 1-217
    Origine
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Source
    • 4
    • 3
    • 2
    • 1
    Escherichia coli (E. coli)
    Purification/Conjugué
    Cette GRB2 protéine est marqué à la His tag.
    Fonction
    Recombinant Human Growth Factor Receptor-Bound Protein 2/GRB2/ASH (C-6His)
    Séquence
    MEAIAKYDFK ATADDELSFK RGDILKVLNE ECDQNWYKAE LNGKDGFIPK NYIEMKPHPW FFGKIPRAKA EEMLSKQRHD GAFLIRESES APGDFSLSVK FGNDVQHFKV LRDGAGKYFL WVVKFNSLNE LVDYHRSTSV SRNQQIFLRD IEQVPQQPTY VQALFDFDPQ EDGELGFRRG DFIHVMDNSD PNWWKGACHG QTGMFPRNYV TPVNRNVLEH HHHHH
    Attributs du produit
    Recombinant Human Growth Factor Receptor-Bound Protein 2/GRB2 is produced by our E. coli expression system. The target protein is expressed with sequence (Met1-Val217) of Human GRB2 fused with a 6His tag at the C-terminus.
    Pureté
    > 95 % as determined by reducing SDS-PAGE.
    Stérilité
    0.2 μm filtered
    niveau d'endotoxine
    Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test
    Top Product
    Discover our top product GRB2 Protéine
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    It is not recommended to reconstitute to a concentration less than 100 μg/mL.
    Dissolve the lyophilized protein in ddH2O.
    Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
    Buffer
    Lyophilized from a 0.2 μm filtered solution of 20 mM TrisHCl, 150 mM NaCl, pH 8.0.
    Conseil sur la manipulation
    Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
    Stock
    4 °C/-20 °C/-80 °C
    Stockage commentaire
    Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
    Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
    Aliquots of reconstituted samples are stable at < -20°C for 3 months.
    Date de péremption
    3 months
  • Antigène
    GRB2 (Growth Factor Receptor-Bound Protein 2 (GRB2))
    Autre désignation
    GRB2 (GRB2 Produits)
    Synonymes
    GRB2 Protein, grb2 Protein, AA408164 Protein, Ash Protein, ASH Protein, EGFRBP-GRB2 Protein, Grb3-3 Protein, MST084 Protein, MSTP084 Protein, NCKAP2 Protein, wu:fb18e12 Protein, wu:fb34e06 Protein, zgc:73077 Protein, growth factor receptor bound protein 2 Protein, growth factor receptor-bound protein 2 Protein, growth factor receptor-bound protein 2b Protein, GRB2 Protein, grb2 Protein, Grb2 Protein, grb2b Protein
    Sub Type
    Fusionprotein
    Sujet
    As an adaptor protein, Growth Factor Receptor-Bound Protein 2 (GRB2) is involved in siganl transduction and consists of a central SH2 domain flanked by two SH3 domains. GRB2 associates with activated Tyr-phosphorylated EGF receptor/EGFR and PDGF receptors via its SH2 domain, stimulating GTP binding to Ras, which in turn activates MAPK and other signaling pathway.It also associates to other cellular Tyr-phosphorylated proteins such as SIT1, IRS1, IRS4, SHC and LNK. probably via the concerted action of both its SH2 and SH3 domains.
    Alternative Names: Growth Factor Receptor-Bound Protein 2, Adapter Protein GRB2, Protein Ash, SH2/SH3 Adapter GRB2, GRB2, ASH
    Poids moléculaire
    26.3 kDa
    UniProt
    P62993
    Pathways
    Signalisation RTK, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Actin Filament Polymerization, Hepatitis C, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, EGFR Downregulation
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