Oncostatin M Receptor Protein (OSMR) (AA 28-739) (His tag)

N° du produit ABIN1096939

Détail du produit

Antigène: Oncostatin M Receptor (OSMR)

Type de proteíne: Recombinant

Attributs du protein: AA 28-739

Origine: Humain

Source: Human Cells

Purification/Conjugué: Cette Oncostatin M Receptor protéine est marqué à la His tag.

Fonction: Recombinant Human Oncostatin-M-Specific Receptor Subunit β/OSMRB/IL-31RB (C-6His)

Séquence: ERLPLTPVSL KVSTNSTRQS LHLQWTVHNL PYHQELKMVF QIQISRIETS NVIWVGNYST TVKWNQVLHW SWESELPLEC ATHFVRIKSL VDDAKFPEPN FWSNWSSWEE VSVQDSTGQD ILFVFPKDKL VEEGTNVTIC YVSRNIQNNV SCYLEGKQIH GEQLDPHVTA FNLNSVPFIR NKGTNIYCEA SQGNVSEGMK GIVLFVSKVL EEPKDFSCET EDFKTLHCTW DPGTDTALGW SKQPSQSYTL FESFSGEKKL CTHKNWCNWQ ITQDSQETYN FTLIAENYLR KRSVNILFNL THRVYLMNPF SVNFENVNAT NAIMTWKVHS IRNNFTYLCQ IELHGEGKMM QYNVSIKVNG EYFLSELEPA TEYMARVRCA DASHFWKWSE WSGQNFTTLE AAPSEAPDVW RIVSLEPGNH TVTLFWKPLS KLHANGKILF YNVVVENLDK PSSSELHSIP APANSTKLIL DRCSYQICVI ANNSVGASPA SVIVISADPE NKEVEEERIA GTEGGFSLSW KPQPGDVIGY VVDWCDHTQD VLGDFQWKNV GPNTTSTVIS TDAFRPGVRY DFRIYGLSTK RIACLLEKKT GYSQELAPSD NPHVLVDTLT SHSFTLSWKD YSTESQPGFI QGYHVYLKSK ARQCHPRFEK AVLSDGSECC KYKIDNPEEK ALIVDNLKPE SFYEFFITPF TSAGEGPSAT FTKVTTPDEH SSVDHHHHHH

Attributs du produit: Recombinant Human Oncostatin-M-Specific Receptor Subunit beta/OSMRB produced by transfected human cells is a secreted protein with sequence (Glu28-Ser739) of Human OSMRB fused with a polyhistidine tag at the C-terminus.

Pureté: > 95 % as determined by reducing SDS-PAGE.

Stérilité: 0.2 μm filtered

niveau d'endotoxine: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.2.

Conseil sur la manipulation: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Stock: 4 °C/-20 °C/-80 °C

Stockage commentaire: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Date de péremption: 3 months

Détail du antigène

Antigène: Oncostatin M Receptor (OSMR)

Autre désignation: Il-31-Rb (OSMR Produits)

Synonymes: OSMRB Protein, PLCA1 Protein, oncostatin M receptor Protein, OSMR Protein, Osmr Protein

Sub Type: Fusionprotein

Sujet: Oncostatin-M-Specific Receptor Subunit beta (OSMRbeta) is a 150 - 180 kDa member of the IL-6 receptor family. OSMRbeta associates with gp130 to form the type II OSM receptor, the receptor is responsive to OSM. Gp130 subunit is shared by other IL-6 family cytokine receptors, and OSMRbeta associates with gp130-like receptor (GPL) to form a receptor complex responsive to IL-31. The human OSMRbeta cDNA encodes a 979 amino acid (aa) precursor, the precursor includes a 27 aa signal sequence, a 712 aa extracellular domain (ECD), a 22 aatransmembrane segment, and a 218 aa cytoplasmic domain. The ECD contains one partial and one complete hematopoietin domain, an Ig-like domain, and three Fibronectin type-III domains.
Alternative Names: Oncostatin-M-Specific Receptor Subunit Beta, Interleukin-31 Receptor Subunit Beta, IL-31 Receptor Subunit Beta, IL-31R Subunit Beta, IL-31R-Beta, IL-31RB, OSMR, OSMRB

Poids moléculaire: 82.03 kDa

UniProt: Q99650

Pathways: Signalistation JAK/STAT, Growth Factor Binding