ARFIP2 Protein (His tag)

N° du produit ABIN1098383

Détail du produit

Antigène: ARFIP2 (ADP-Ribosylation Factor Interacting Protein 2 (ARFIP2))

Type de proteíne: Recombinant

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette ARFIP2 protéine est marqué à la His tag.

Application: SDS-PAGE (SDS)

Purification: purified by chromatography

Pureté: > 90 % by SDS - PAGE

Information d'application

Commentaires:

Synonyms: Arfaptin 2, POR1

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.25 mg/ml (determined by Bradford assay)

Buffer: 20 mM Tris-HCl buffer (pH 8.0) containing 0.2 M NaCl, 40% glycerol,1 MM DTT

Stock: 4 °C

Stockage commentaire: Avoid repeated freezing and thawing cycles.

Détail du antigène

Antigène: ARFIP2 (ADP-Ribosylation Factor Interacting Protein 2 (ARFIP2))

Autre désignation: ARFIP2 (ARFIP2 Produits)

Synonymes: POR1 Protein, 2310002N04Rik Protein, POR Protein, Por1 Protein, ARFIP2 Protein, im:7136059 Protein, zgc:112066 Protein, ADP ribosylation factor interacting protein 2 Protein, ADP-ribosylation factor interacting protein 2 Protein, ADP-ribosylation factor interacting protein 2b Protein, ARFIP2 Protein, Arfip2 Protein, arfip2b Protein

Sujet: Arfaptin 2, also known as ARFIP2, is a Rac1 binding protein necessary for Rac-mediated actin polymerization and the subsequent formation of membrane ruffles and lamellipodia. ARFIP2 has also been shown to interact with the ADP ribosylation factor ARF6, a GTPase that associates with the plasma membrane and intracellular endosome vesicles, in a GTP dependent manner. Arfaptin 2 also regulates the aggregation of mutant Huntingtin protein by possibly impairing proteasome function. Expression of ARFIP2 was shown to be increased at sites of neurodegeneration. Recombinant human ARFIP2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Poids moléculaire: 40.2 kDa (364aa), confirmed by MALDI-TOF

NCBI Accession: NP_036534