TK1 Protein (His tag)

N° du produit ABIN1098640

Détail du produit

Antigène: TK1 (Thymidine Kinase 1, Soluble (TK1))

Type de proteíne: Recombinant

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette TK1 protéine est marqué à la His tag.

Application: SDS-PAGE (SDS)

Purification: purified by using conventional chromatography.

Pureté: > 90 % by SDS - PAGE

Information d'application

Commentaires:

Synonyms: Thymidine kinase, cytosolic, TK2

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/ml (determined by Bradford assay)

Buffer: 20 mM Tris-HCl buffer (pH 8.0) containing 20% glycerol, 0.1 M NaCl, 1 MM DTT

Stock: 4 °C

Stockage commentaire: Avoid repeated freezing and thawing cycles.

Détail du antigène

Antigène: TK1 (Thymidine Kinase 1, Soluble (TK1))

Autre désignation: TK1 (TK1 Produits)

Synonymes: fi19b06 Protein, zgc:55362 Protein, wu:fi19b06 Protein, TK1 Protein, tk2 Protein, D530002A18Rik Protein, Tk-1 Protein, Tk1a Protein, Tk1b Protein, TK2 Protein, Tk Protein, TK Protein, thymidine kinase 1, soluble Protein, thymidine kinase 1 Protein, thymidine kinase, cytosolic Protein, Thymidine kinase, cytosolic Protein, temporal expression: early Protein, thymidine kinase Protein, Tk thymidine kinase Protein, tk1 Protein, TK1 Protein, EDI_049980 Protein, kith Protein, J2R Protein, HVT031 Protein, Tk1 Protein, tk Protein

Sujet: TK1, also known as thymidine kinase, is an enzyme, a phosphotransferase (a kinase): 2'-deoxythymidine kinase, ATP-thymidine 5'-phosphotransferase. It is present in two forms in mammalian cells, TK1 and TK2. Thymidine kinases have a key function in the synthesis of DNA and thereby in cell division, as they are part of the unique reaction chain to introduce deoxythymidine into the DNA. Deoxythymidine is present in the body fluids as a result of degradation of DNA from food and from dead cells. Thymidine kinase is required for the action of many antiviral drugs. It is used to select hybridoma cell lines in production of monoclonal antibodies. In clinical chemistry it is used as a proliferation marker in the diagnosis, control of treatment and follow-up of malignant disease, mainly of hematological malignancies. Recombinant human TK1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.

Poids moléculaire: 28.0 kDa (258aa) confirmed by MALDI-TOF

NCBI Accession: NP_003249