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IDO1 Protein (AA 1-407) (His tag)

IDO1 Origine: Souris Hôte: Escherichia coli (E. coli) Recombinant >90 % (SDS-PAGE) SDS Active
N° du produit ABIN1344081
  • Antigène Voir toutes IDO1 Protéines
    IDO1 (Indoleamine 2,3-Dioxygenase 1 (IDO1))
    Type de proteíne
    Recombinant
    Activité biologique
    Active
    Attributs du protein
    AA 1-407
    Origine
    • 10
    • 3
    • 1
    Souris
    Source
    • 7
    • 2
    • 2
    • 2
    • 1
    Escherichia coli (E. coli)
    Purification/Conjugué
    Cette IDO1 protéine est marqué à la His tag.
    Application
    SDS-PAGE (SDS)
     Réactivité croisée
    Souris
    Attributs du produit
    Mouse IDO (aa 1-407) is fused at the C-terminus to a His-tag.
    Pureté
    >90 % (SDS-PAGE)
    Stérilité
    0.2 μm filtered
    niveau d'endotoxine
    <1EU/μg purified protein (LAL test, Lonza).
    Top Product
    Discover our top product IDO1 Protéine
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Commentaires

    Specific Activity: >100'000U/mg protein with L-tryptophan as substrate and after addition of 7μM hemin for protein induction. One unit is defined as the amount of enzyme that produces 1nmol of kynurenine per hour.

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    0.2μm-filtered solution in 50 mM TRIS-Cl, pH 7.4, containing 1 mM EDTA.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Short Term Storage: +4°C
    Long Term Storage: -20°C
    Working aliquots are stable for up to 3 months when stored at -20°C.
    Date de péremption
    3 months
  • Antigène
    IDO1 (Indoleamine 2,3-Dioxygenase 1 (IDO1))
    Autre désignation
    IDO (IDO1 Produits)
    Synonymes
    INDO Protein, ido Protein, indo Protein, IDO Protein, cd107b Protein, IDO1 Protein, IDO-1 Protein, Ido Protein, Indo Protein, indoleamine 2,3-dioxygenase 1 Protein, indoleamine 2,3-dioxygenase 1 L homeolog Protein, indoleamine 2,3-dioxygenase 1-like Protein, IDO1 Protein, ido1.L Protein, ido1 Protein, Ido1 Protein, LOC100050681 Protein
    Sujet
    IDO catalyzes the first and rate-limiting step in the main pathway of human tryptophan catabolism, the kynurenine pathway. Proinflammatory mediators, such as endotoxin and IFN-gamma induce the expression of IDO in several tissues. IDO-dependent suppression of T cell responses might function as natural immunoregulatory mechanism. Physiological IDO activity has been implicated in T cell tolerance to tumors, dysfunctional selftolerance in non-obese diabetic (NOD) mice, and as a protective negative regulator in autoimmune disorders.
    Poids moléculaire
    ~40kDa (SDS-PAGE)
    UniProt
    P28776
    Pathways
    Activated T Cell Proliferation
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