ANGPTL4 Protein (AA 1-410) (DYKDDDDK Tag)

N° du produit ABIN1344083

Détail du produit

Antigène: ANGPTL4 (Angiopoietin-Like 4 (ANGPTL4))

Type de proteíne: Recombinant

Activité biologique: Active

Attributs du protein: AA 1-410

Origine: Souris

Source: COS-7 Cells

Purification/Conjugué: Cette ANGPTL4 protéine est marqué à la DYKDDDDK Tag.

Application: SDS-PAGE (SDS)

Réactivité croisée: Souris

Attributs du produit: Mouse ANGPTL4 (aa 1-410) is fused at the C-terminus to a FLAG®-tag.

Pureté: >90 % (SDS-PAGE)

Stérilité: 0.2 μm filtered

niveau d'endotoxine: <0.1EU/μg purified protein (LAL test, Lonza).

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

Activates ERK phosphorylation in THP-1 cells.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: 0.2μm-filtered solution in PBS.

Stock: 4 °C,-20 °C

Stockage commentaire: Short Term Storage: +4°C
Long Term Storage: -20°C
Working aliquots are stable for up to 3 months when stored at -20°C.

Date de péremption: 3 months

Détail du antigène

Antigène: ANGPTL4 (Angiopoietin-Like 4 (ANGPTL4))

Autre désignation: ANGPTL4 (ANGPTL4 Produits)

Synonymes: ANGPTL2 Protein, ARP4 Protein, FIAF Protein, HFARP Protein, NL2 Protein, PGAR Protein, pp1158 Protein, Arp4 Protein, Bk89 Protein, Fiaf Protein, Hfarp Protein, Ng27 Protein, Pgar Protein, Pgarg Protein, Pp1158 Protein, ANGPTL4 Protein, fiaf Protein, im:7144703 Protein, si:rp71-39b20.7 Protein, angiopoietin like 4 Protein, angiopoietin-like 4 Protein, ANGPTL4 Protein, Angptl4 Protein, angptl4 Protein

Sujet: ANGPTL4 (Angiopoietin-like protein 4) mainly expressed in endothelial cells (hypoxia-induced). Regulates angiogenesis and modulates tumorigenesis and directly regulates lipid, glucose, and energy metabolism. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. ANGPTL4 is a protein consisting of an N-terminal coiled-coil domain and a C-terminal fibrinogen-like domain (FLD). Both domains have distinct biological functions. The coiled-coil domain is responsible for the inhibitory effects on lipoprotein lipase (LPL) converting the active form of LPL into an inactive form, and the FLD domain mediates its antiangiogenic functions. The coiled coil and the FLD domains are separated by a short linker that can be cleaved after secretion. ANGPTL4 appears on the cell surface as the full-length form, where it can be released by heparin treatment. ANGPTL4 protein is then proteolytically cleaved by proprotein convertases (PCs), including furin, PC5/6, paired basic amino acid-cleaving enzyme 4, and PC7.

Poids moléculaire: ~50kDa (SDS-PAGE)

UniProt: Q9Z1P8

Pathways: Regulation of Lipid Metabolism by PPARalpha