Clusterin Protein (CLU) (AA 23-449, Nuclear) (His tag)

N° du produit ABIN1344142

Détail du produit

Antigène: Clusterin (CLU)

Type de proteíne: Recombinant

Attributs du protein: Nuclear, AA 23-449

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette Clusterin protéine est marqué à la His tag.

Application: SDS-PAGE (SDS)

Réactivité croisée: Humain

Attributs du produit: Human nuclear clusterin (aa 23-449) is fused at the C-terminus to a His-tag.

Pureté: >90 % (SDS-PAGE)

Stérilité: 0.2 μm filtered

niveau d'endotoxine: <1EU/μg purified protein (LAL test, Lonza).

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: 0.2μm-filtered solution in 55 mM TRIS-Cl, pH 8.2, containing 150 mM NaCl.

Stock: 4 °C,-20 °C

Stockage commentaire: Short Term Storage: +4°C
Long Term Storage: -20°C
Working aliquots are stable for up to 3 months when stored at -20°C.

Date de péremption: 3 months

Référence

Shim, Kang, Jeon, Park, Lee, Lee, Park, Lee, Schedin, Min: "Clusterin induces matrix metalloproteinase-9 expression via ERK1/2 and PI3K/Akt/NF-?B pathways in monocytes/macrophages." dans: Journal of leukocyte biology, Vol. 90, Issue 4, pp. 761-9, (2011) (PubMed).

Détail du antigène

Antigène: Clusterin (CLU)

Autre désignation: Clusterin (CLU Produits)

Synonymes: LOC100136120 Protein, clu Protein, MGC53055 Protein, zgc:73352 Protein, xclu Protein, MGC89163 Protein, CLU Protein, APO-J Protein, APOJ Protein, CLI Protein, CLU1 Protein, CLU2 Protein, KUB1 Protein, NA1/NA2 Protein, SGP-2 Protein, SGP2 Protein, SP-40 Protein, TRPM-2 Protein, TRPM2 Protein, DAG Protein, RATTRPM2B Protein, SP40 Protein, TRPM2B Protein, Trpm2 Protein, Trpmb Protein, AI893575 Protein, ApoJ Protein, Cli Protein, D14Ucla3 Protein, Sgp-2 Protein, Sgp2 Protein, Sugp-2 Protein, GP80 Protein, gpIII Protein, 40 Protein, clusterin-1 Protein, clusterin L homeolog Protein, clusterin Protein, Clusterin Protein, LOC100136120 Protein, clu.L Protein, clu Protein, CLU Protein, clus Protein, Clu Protein, LOC101113728 Protein

Sujet: Clusterin shares homology with the small heat shock protein family of molecular chaperones. The mature secreted form of the protein is a glycosylated, 80- kDa disulfide-linked heterodimer of alpha and beta subunits (produced by internal cleavage). Clusterin is expressed in virtually all tissues and found in all human fluids. It is involved in numerous physiological processes important for carcinogenesis and tumor growth, including apoptotic cell death, cell cycle regulation, DNA repair, cell adhesion, tissue remodeling, lipid transportation, membrane recycling, and immune system regulation. Clusterin also exists as a nuclear protein. The secreted form of Clusterin has extracellular chaperone and anti-apoptotic activities while the nuclear form acts as a proapoptotic factor.

Poids moléculaire: ~45kDa (SDS-PAGE)

UniProt: P10909

Pathways: Apoptose, Negative Regulation of intrinsic apoptotic Signaling