HES1 Protein (AA 2-280) (His tag)

N° du produit ABIN1344335

Détail du produit

Antigène: HES1 (Hes Family bHLH Transcription Factor 1 (HES1))

Type de proteíne: Recombinant

Attributs du protein: AA 2-280

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette HES1 protéine est marqué à la His tag.

Application: SDS-PAGE (SDS)

Réactivité croisée: Humain

Attributs du produit: Human HES1 (aa 2-280) is fused at the N-terminus to a His-tag.

Pureté: >90 % (SDS-PAGE)

Stérilité: 0.2 μm filtered

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: 0.2μm-filtered solution in 55 mM TRIS-Cl, pH 8.2, containing 150 mM NaCl.

Stock: 4 °C,-20 °C

Stockage commentaire: Short Term Storage: +4°C
Long Term Storage: -20°C
Working aliquots are stable for up to 3 months when stored at -20°C.

Date de péremption: 3 months

Détail du antigène

Antigène: HES1 (Hes Family bHLH Transcription Factor 1 (HES1))

Autre désignation: HES1 (HES1 Produits)

Synonymes: HES-1 Protein, HHL Protein, HRY Protein, bHLHb39 Protein, Hry Protein, HAIRY1 Protein, c-hairy1A Protein, Xhairy1 Protein, hairy1 Protein, hes1 Protein, Xhairy-1 Protein, Xlh1 Protein, hes family bHLH transcription factor 1 Protein, hairy and enhancer of split 1 (Drosophila) Protein, hes family bHLH transcription factor 4 Protein, hes family bHLH transcription factor 1 S homeolog Protein, hes family bHLH transcription factor 1 L homeolog Protein, HES1 Protein, Hes1 Protein, HES4 Protein, hes1.S Protein, hes1.L Protein

Sujet: BHLH proteins are essential for neurogenesis, myogenesis, hematopoiesis and sex determination. HES1 (Hairy and Enhancer of Split 1) is a basic Helix-Loop-Helix (bHLH) transcriptional repressor regulated by the Notch pathway and expressed in various tissues. HES1 is well known in development of different tissues, particularly endoderm derived endocrine organs like pancreas and neuroendocrine cells of lung. HES1 controls normal development by regulating proliferation and differentiation and so cell fate. Notch signaling plays both oncogenic and tumor suppressor roles depending on cell type. In contrast to T cell acute lymphoblastic leukemia (ALL), where Notch activation promotes leukemogenesis, induction of Notch signaling in B cell ALL (B-ALL) leads to growth arrest and apoptosis. The Notch target HES1 is sufficient to reproduce this tumor suppressor phenotype in B-ALL by interacting and activating PARP-1 and regulating proapoptotic signals.

Poids moléculaire: ~35kDa (SDS-PAGE)

UniProt: Q14469

Pathways: Réparation de l'ADN