IGFL3 Protein (AA 25-140) (DYKDDDDK Tag)

N° du produit ABIN1344381

Détail du produit

Antigène: IGFL3 (IGF-Like Family Member 3 (IGFL3))

Type de proteíne: Recombinant

Attributs du protein: AA 25-140

Origine: Souris

Source: HEK-293 Cells

Purification/Conjugué: Cette IGFL3 protéine est marqué à la DYKDDDDK Tag.

Application: SDS-PAGE (SDS)

Réactivité croisée: Souris

Attributs du produit: Mouse IGFL (aa 25-140) is fused at the N-terminus to a FLAG®-tag.

Pureté: >95 % (SDS-PAGE)

niveau d'endotoxine: <0.1EU/μg purified protein (LAL test, Lonza).

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Reconstitute with 100 μL sterile water.

Concentration: Lot specific

Buffer: Lyophilized. Contains PBS.

Stock: 4 °C,-20 °C

Stockage commentaire: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 6 months after receipt when stored at -20°C.

Date de péremption: 6 months

Référence

Lobito, Ramani, Tom, Bazan, Luis, Fairbrother, Ouyang, Gonzalez: "Murine insulin growth factor-like (IGFL) and human IGFL1 proteins are induced in inflammatory skin conditions and bind to a novel tumor necrosis factor receptor family member, IGFLR1." dans: The Journal of biological chemistry, Vol. 286, Issue 21, pp. 18969-81, (2011) (PubMed).

Détail du antigène

Antigène: IGFL3 (IGF-Like Family Member 3 (IGFL3))

Autre désignation: IGFL (IGFL3 Produits)

Synonymes: UNQ483 Protein, Gm580 Protein, Igfl Protein, Rprc483 Protein, Ceacam12 Protein, IGF like family member 3 Protein, IGF-like family member 3 Protein, IGFL3 Protein, Igfl3 Protein

Sujet: Insulin-growth factor-like gene family is a new family of proteins consisting of four proteins in humans (IGFL1 to 4) and one in mice (mIGFL). mIGFL is expressed in normal skin in mice and further upregulated during inflammation responses in skin or after skin wounding. In human only IGFL1 expression is increased in psoriatic skin samples. mIGFL and human IGFL1 and 3 interact with specificity and high affinity to a novel receptor named IGF-like family receptor 1 (formerly TMEM-149). Analysis of the amino acid sequence of IGFLR1 indicated that this receptor is likely a novel member of the TNF-R family. IGFLR1 is expressed most abundantly on mouse T cells, suggesting that mIGFL and IGFL1 produced in the skin may potentially exert regulatory functions on T cell responses.

Poids moléculaire: ~12kDa (SDS-PAGE)

UniProt: Q6B9Z0