LAG3 Protein (Fc Tag)

N° du produit ABIN1344460

Détail du produit

Antigène: LAG3 (Lymphocyte-Activation Gene 3 (LAG3))

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Humain, Souris

Source: CHO Cells

Purification/Conjugué: Cette LAG3 protéine est marqué à la Fc Tag.

Application: SDS-PAGE (SDS), Flow Cytometry (FACS)

Specificité: Binds to human and mouse MHC class II.

Réactivité croisée: Humain, Souris

Attributs du produit: The sequence coding for the 4 extracellular Ig-like domains of mouse LAG-3 (D1-D4) is fused to the Fc portion of mouse IgG2a (hinge-CH2-CH3).

Pureté: >95 % (SDS-PAGE)

niveau d'endotoxine: <0.01EU/μg purified protein (LAL test, Lonza).

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

Flow Cytometry: Detection of MHC class II molecules in combination with fluorescently labeled antibodies to IgG2a. Uni-Prot link Q61790: LAG-3 (mouse) http://www.uniprot.org/uniprot/Q61790Induces maturation of mouse dendritic cells in vitro. Induces CD4 and CD8 antigen-specific T cells responses when coinjected s.c. in mice, together with the antigen.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: In PBS.

Stock: -20 °C

Stockage commentaire: Short Term Storage: -20°C
Long Term Storage: -20°C
Stable for at least 6 months after receipt when stored at -20°C.

Date de péremption: 6 months

Référence

Cappello, Triebel, Iezzi, Caorsi, Quaglino, Lollini, Amici, Di Carlo, Musiani, Giovarelli, Forni: "LAG-3 enables DNA vaccination to persistently prevent mammary carcinogenesis in HER-2/neu transgenic BALB/c mice." dans: Cancer research, Vol. 63, Issue 10, pp. 2518-25, (2003) (PubMed).

Détail du antigène

Antigène: LAG3 (Lymphocyte-Activation Gene 3 (LAG3))

Autre désignation: LAG-3 (LAG3 Produits)

Synonymes: CD223 Protein, LAG-3 Protein, Ly66 Protein, lymphocyte activating 3 Protein, lymphocyte-activation gene 3 Protein, LAG3 Protein, Lag3 Protein

Sujet: Lymphocyte activation gene 3 (LAG-3, CD223) plays an important role in negatively regulating T cell proliferation, function and homeostasis. It is required for maximal natural and induced regulatory T cell (Treg) function. LAG-3 is closely related to the T cell co-receptor CD4 and binds to MHC class II molecules but with a significantly higher affinity than CD4.

Poids moléculaire: ~180kDa (SPS-PAGE, nonreducing), ~80kDa (SPS-PAGE, reducing)

UniProt: Q61790

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints