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PDCD10 Protein (His tag)

PDCD10 Origine: Humain Hôte: Escherichia coli (E. coli) Recombinant > 95 % by SDS-PAGE. Visualized by silver stain
N° du produit ABIN1589742
  • Antigène Voir toutes PDCD10 Protéines
    PDCD10 (Programmed Cell Death 10 (PDCD10))
    Type de proteíne
    Recombinant
    Origine
    • 7
    • 1
    • 1
    Humain
    Source
    • 5
    • 2
    • 1
    • 1
    Escherichia coli (E. coli)
    Purification/Conjugué
    Cette PDCD10 protéine est marqué à la His tag.
    Séquence
    MGSSHHHHHHSSGLVPRGSMRMTMEEMKNEAETTSMVSMP LYAVMYPVFNELERVNLSAAQTLRAAFIKAEKENPGLTQD IIMKILEKKSVEVNFTESLLRMAADDVEEYMIERPEPEFQ DLNEKARALKQILSKIPDEINDRVRFLQTIKDIASAIKEL LDTVNNVFKKYQYQNRRALEHQKKEFVKYSKSFSDTLKTY FKDGKAINVFVSANRLIHQTNLILQTFKTVA
    Attributs du produit
    Length (AA): 231
    Chromosomal location: 3q26.1
    Pureté
    > 95 % by SDS-PAGE. Visualized by silver stain
    Top Product
    Discover our top product PDCD10 Protéine
  • Indications d'application
    Not determined yet.
    Commentaires

    Cytokines & Growth Factors

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    The lyophilized CCM3 is soluble in water and most aqueous buffers and should be reconstituted in water or PBS.
    Buffer
    PBS
    Stock
    -20 °C/-80 °C
    Stockage commentaire
    Lyophilized samples are stable for greater than six months at -20 °C to -70 °C. Reconstituted CCM-3 should be stored in working aliquots at -20 °C.
    Date de péremption
    6 months
  • Antigène
    PDCD10 (Programmed Cell Death 10 (PDCD10))
    Autre désignation
    CCM-3 (PDCD10 Produits)
    Synonymes
    CCM3 Protein, TFAR15 Protein, 2410003B13Rik Protein, Ccm3 Protein, Tfa15 Protein, Tfar15 Protein, zgc:85629 Protein, ccm3a Protein, pdcd10 Protein, zgc:65826 Protein, programmed cell death 10 Protein, programmed cell death 10 S homeolog Protein, programmed cell death 10b Protein, programmed cell death 10a Protein, PDCD10 Protein, Pdcd10 Protein, pdcd10.S Protein, pdcd10b Protein, pdcd10a Protein
    Sujet
    Cerebral cavernous malformations (CCMs) are sporadically acquired or inherited vascular lesions of the central nervous system consisting of clusters of dilated thin-walled blood vessels that predispose individuals to seizures and stroke. Mutations in CCM1, CCM2, or CCM3 lead to cerebral cavernous malformations, one of the most common hereditary vascular diseases of the brain. Endothelial cells within these lesions are the main disease compartments. Here, we show that adenoviral CCM3 expression inhibits endothelial cell migration, proliferation, and tube formation while down regulation of endogenous CCM3 results in increased formation of tube-like structures. Adenoviral CCM3 expression does not induce apoptosis under normal endothelial cell culture conditions but protects endothelial cells from staurosporine-induced cell death. Tyrosine kinase activity profiling suggests that CCM3 supports PDPK-1/Akt-mediated endothelial cell quiescence and survival (Schleider et al, Neurogenetics 12, 2011). The CCM-3 is fused to a N-terminal His-tag (6x His).
    Synonyms: PDCD10, CCM3, TFAR15, programmed cell death 10
    Poids moléculaire
    26.7 kDa
    NCBI Accession
    NP_009148, NM_007217
    UniProt
    Q9BUL8
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