MESP1 Protéine
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- Antigène Voir toutes MESP1 Protéines
- MESP1 (Mesoderm Posterior 1 (MESP1))
- Type de proteíne
- Recombinant
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Origine
- Humain
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Source
- Cellules d'insectes
- Séquence
- MAQPLCPPLS ESWMLSAAWG PTRRPPPSDK DCGRSLVSSP DSWGSTPADS PVASPARPGT LRDPRAPSVG RRGARSSRLG SGQRQSASER EKLRMRTLAR ALHELRRFLP PSVAPAGQSL TKIETLRLAI RYIGHLSAVL GLSEESLQRR CRQRGDAGSP RGCPLCPDDC PAQMQTRTQA EGQGQGRGLG LVSAVRAGAS WGSPPACPGA RAAPEPRDPP ALFAEAACPE GQAMEPSPPS PLLPGDVLAL LETWMPLSPL EWLPEEPK
- Attributs du produit
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Length (AA): 268
Chromosomal location: 15q26.1 - Pureté
- > 95 % by SDS-PAGE. Visualized by silver stain
- Top Product
- Discover our top product MESP1 Protéine
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Mesoderm Posterior 1 (MESP1) (AA 1-63) protein (GST tag)
MESP1 Origine: Humain Hôte: Wheat germ Recombinant ELISA, WB, AP, AA
Mesoderm Posterior 1 (MESP1) (AA 1-243) protein (Strep Tag)Crystallography grade MESP1 Origine: Souris Hôte: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS
Mesoderm Posterior 1 (MESP1) (AA 1-268) protein (Strep Tag)Crystallography grade MESP1 Origine: Humain Hôte: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS
Mesoderm Posterior 1 (MESP1) protein (Myc-DYKDDDDK Tag)MESP1 Origine: Humain Hôte: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- Indications d'application
- Not determined yet.
- Commentaires
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Cytokines & Growth Factors
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Human MesP1 should be reconstituted in sterile water to a concentration of 0.1 mg/mL. This solution can be diluted in water or other buffer solutions or stored at -20 °C.
- Buffer
- 0.5X PBS
- Conseil sur la manipulation
- Freeze/thaw cycles will result in significant loss of activity.
- Stock
- 0 °C
- Stockage commentaire
- The lyophilized human MesP1, though stable at room temperature, is best stored desiccated below 0 °C.
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- Antigène
- MESP1 (Mesoderm Posterior 1 (MESP1))
- Autre désignation
- MesP1 (MESP1 Produits)
- Synonymes
- bHLHc5 Protein, mesp Protein, mesp1 Protein, mespa Protein, CMESO-1 Protein, CMESO2 Protein, MESP1 Protein, mesoderm posterior 1 Protein, mesoderm posterior bHLH transcription factor 1 Protein, mesoderm posterior 1 homolog (mouse) Protein, mesoderm posterior homolog B Protein, mesoderm posterior homolog B L homeolog Protein, Mesp1 Protein, MESP1 Protein, mesp1 Protein, mespb Protein, mespb.L Protein
- Sujet
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ES-cell-based cardiovascular repair requires an in-depth understanding of the molecular mechanisms underlying the differentiation of cardiovascular ES cells. A candidate cardiovascular-fate inducer is the bHLH transcription factor MesP1 (1,2). As one of the earliest markers, it is expressed specifically in almost all cardiovascular precursors and is required for cardiac morphogenesis (2,3). It was shown that MesP1 is a key factor sufficient to induce the formation of ectopic heart tissue in vertebrates and increase cardiovasculogenesis by ES cells. Electrophysiological analysis showed all subtypes of cardiac ES-cell differentiation (4). MesP1 overexpression and knockdown experiments revealed a prominent function of MesP1 in a gene regulatory cascade, causing Dkk-1-mediated blockade of canonical Wnt-signalling. Independent evidence from ChIP and in vitro DNA-binding studies, expression analysis in wild-type and MesP knockout mice, and reporter assays confirm that Dkk-1 is a direct target of MesP1.
Synonyms: MESP1, bHLHc5 - Poids moléculaire
- 34 kDa
- NCBI Accession
- NM_018670, NP_061140
- UniProt
- Q9BRJ9
- Pathways
- Regulation of Muscle Cell Differentiation
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