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CCM2 Protein (His tag)

CCM2 Origine: Humain Hôte: Escherichia coli (E. coli) Recombinant > 95 % by SDS-PAGE. Visualized by silver stain
N° du produit ABIN1589765
  • Antigène Voir toutes CCM2 Protéines
    CCM2 (Cerebral Cavernous Malformation 2 (CCM2))
    Type de proteíne
    Recombinant
    Origine
    • 5
    • 1
    Humain
    Source
    • 2
    • 2
    • 1
    • 1
    Escherichia coli (E. coli)
    Purification/Conjugué
    Cette CCM2 protéine est marqué à la His tag.
    Séquence
    MGSSHHHHHHSSGLVPRGSHMEEEGKKGKKPGIVSPFKRV FLKGEKSRDKKAHEKVTERRPLHTVVLSLPERVEPDRLLS DYIEKEVKYLGQLTSIPGYLNPSSRTEILHFIDNAKRAHQ LPGHLTQEHDAVLSLSAYNVKLAWRDGEDIILRVPIHDIA AVSYVRDDAAHLVVLKTAQDPGISPSQSLCAESSRGLSAG SLSESAVGPVEACCLVILAAESKVAAEELCCLLGQVFQVV YTESTIDFLDRAIFDGASTPTHHLSLHSDDSSTKVDIKET YEVEASTFCFPESVDVGGASPHSKTISESELSASATELLQ DYMLTLRTKLSSQEIQQFAALLHEYRNGASIHEFCINLRQ LYGDSRKFLLLGLRPFIPEKDSQHFENFLETIGVKDGRGI ITDSFGRHRRALSTTSSSTTNGNRATGSSDDRSAPSEGDE WDRMISDISSDIEALGCSMDQDSA
    Attributs du produit
    Length (AA): 464
    Chromosomal location: 7p13
    Pureté
    > 95 % by SDS-PAGE. Visualized by silver stain
    Top Product
    Discover our top product CCM2 Protéine
  • Indications d'application
    Not tested so far.
    Commentaires

    Cytokines & Growth Factors

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    The lyophilized CCM-2 is soluble in water and most aqueous buffers and should be reconstituted in water or PBS.
    Buffer
    PBS
    Stock
    0 °C
    Stockage commentaire
    The lyophilized human CCM2, though stable at room temperature, is best stored desiccated below 0 °C.
  • Antigène
    CCM2 (Cerebral Cavernous Malformation 2 (CCM2))
    Autre désignation
    CCM-2 (CCM2 Produits)
    Synonymes
    C7orf22 Protein, OSM Protein, malcavernin Protein, CCM2 Protein, BC029157 Protein, TUF2 Protein, vtn Protein, zgc:110233 Protein, CCM2 scaffolding protein Protein, cerebral cavernous malformation 2 Protein, malcavernin Protein, CCM2 Protein, Ccm2 Protein, LOC100304744 Protein, ccm2 Protein
    Sujet
    Cerebral cavernous malformations (CCMs) are sporadically acquired or inherited vascular lesions of the central nervous system consisting of clusters of dilated thin-walled blood vessels that predispose individuals to seizures and stroke. Familial CCM is caused by mutations in KRIT1 (CCM1) or in malcavernin (CCM2). The roles of the CCM proteins in the pathogenesis of the disorder remain largely unknown. It was shown that the CCM1 gene product, KRIT1, interacts with the CCM2 gene product, malcavernin. Analogous to the established interactions of CCM1 and beta1 integrin with ICAP1, the CCM1/CCM2 association is dependent upon the phosphotyrosine binding (PTB) domain of CCM2. A familial CCM2 missense mutation abrogates the CCM1/CCM2 interaction, suggesting that loss of this interaction may be critical in CCM pathogenesis. CCM2 and ICAP1 bound to CCM1 via their respective PTB domains differentially influence the subcellular localization of CCM1. The data indicate that the genetic heterogeneity observed in familial CCM may reflect mutation of different molecular members of a coordinated signaling complex. The CCM-2 is fused to a N-terminal His-tag (6x His).
    Synonyms: CCM-2, malcavernin, cerebral cavernous malformation 2, OSM, C7orf22, PP10187
    Poids moléculaire
    51.0 kDa
    NCBI Accession
    NP_001025006, NM_001029835
    UniProt
    Q9BSQ5
    Pathways
    Cell-Cell Junction Organization
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