ICAM1 Protein (AA 26-480) (Fc Tag)

N° du produit ABIN1691618

Détail du produit

Antigène: ICAM1 (Intercellular Adhesion Molecule 1 (ICAM1))

Type de proteíne: Recombinant

Attributs du protein: AA 26-480

Origine: Humain

Source: Human Cells

Purification/Conjugué: Cette ICAM1 protéine est marqué à la Fc Tag.

Fonction: Recombinant Human Intercellular Adhesion Molecule 1/ICAM-1/CD54 (C-Fc)

Séquence: NAQTSVSPSK VILPRGGSVL VTCSTSCDQP KLLGIETPLP KKELLLPGNN RKVYELSNVQ EDSQPMCYSN CPDGQSTAKT FLTVYWTPER VELAPLPSWQ PVGKNLTLRC QVEGGAPRAN LTVVLLRGEK ELKREPAVGE PAEVTTTVLV RRDHHGANFS CRTELDLRPQ GLELFENTSA PYQLQTFVLP ATPPQLVSPR VLEVDTQGTV VCSLDGLFPV SEAQVHLALG DQRLNPTVTY GNDSFSAKAS VSVTAEDEGT QRLTCAVILG NQSQETLQTV TIYSFPAPNV ILTKPEVSEG TEVTVKCEAH PRAKVTLNGV PAQPLGPRAQ LLLKATPEDN GRSFSCSATL EVAGQLIHKN QTRELRVLYG PRLDERDCPG NWTWPENSQQ TPMCQAWGNP LPELKCLKDG TFPLPIGESV TVTRDLEGTY LCRARSTQGE VTRKVTVNVL SPRYEVDDIE GRMDEPKSCD KTHTCPPCPA PELLGGPSVF LFPPKPKDTL MISRTPEVTC VVVDVSHEDP EVKFNWYVDG VEVHNAKTKP REEQYNSTYR VVSVLTVLHQ DWLNGKEYKC KVSNKALPAP IEKTISKAKG QPREPQVYTL PPSREEMTKN QVSLTCLVKG FYPSDIAVEW ESNGQPENNY KTTPPVLDSD GSFFLYSKLT VDKSRWQQGN VFSCSVMHEA LHNHYTQKSL SLSPGK

Attributs du produit: Recombinant Human Intercellular Adhesion Molecule 1/ICAM-1 is produced by our mammalian expression system. The target protein is expressed with sequence (Asn26 ­ Glu480) ofHuman CD54 fused with a FC tag at the C-terminus.

Pureté: > 95 % as determined by reducing SDS-PAGE.

Stérilité: 0.2 μm filtered

niveau d'endotoxine: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl, pH 7.4.

Conseil sur la manipulation: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Stock: 4 °C/-20 °C/-80 °C

Stockage commentaire: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Date de péremption: 5 months

Détail du antigène

Antigène: ICAM1 (Intercellular Adhesion Molecule 1 (ICAM1))

Autre désignation: CD54 (ICAM1 Produits)

Synonymes: BB2 Protein, CD54 Protein, P3.58 Protein, Icam-1 Protein, Ly-47 Protein, MALA-2 Protein, ICAM Protein, ICAM-1 Protein, ICAM1 Protein, intercellular adhesion molecule 1 Protein, intercellular adhesion molecule-1 Protein, ICAM1 Protein, Icam1 Protein, ICAM-1 Protein

Sub Type: Fusionprotein

Classe de substances: Viral Protein

Sujet: Inter-Cellular Adhesion Molecule 1 (ICAM1) is a type of intercellular adhesion molecule continuously present in low concentrations in the membranes of leukocytes and endothelial cells. As an endothelial and leukocyte-associated transmembrane protein, ICAM1 is well known for its importance in stabilizing cell-cell interactions and facilitating leukocyte endothelial transmigration. The presence of heavy glycosylation and other structural characteristics lend ICAM1 binding sites for a number of immune-associated ligands. Notably, ICAM-1 binds to macrophage adhesion ligand-1 (Mac-1, ITGB2 / ITGAM), leukocyte function associated antigen-1 (LFA-1/integrin), and fibrinogen.ICAM-1 expressed by respiratory epithelial cells is also the binding site for rhinovirus, the causative agent of most common colds.
Alternative Names: Intercellular Adhesion Molecule 1, ICAM-1, Major Group Rhinovirus Receptor, CD54, ICAM1

Poids moléculaire: 76.8 kDa

UniProt: P05362

Pathways: Cellular Response to Molecule of Bacterial Origin, Regulation of Actin Filament Polymerization, Carbohydrate Homeostasis, Regulation of Leukocyte Mediated Immunity, Thromboxane A2 Receptor Signaling