STAT1 Protein (AA 1-712)

N° du produit ABIN1692001

Détail du produit

Antigène: STAT1 (Signal Transducer and Activator of Transcription 1, 91kDa (STAT1))

Type de proteíne: Recombinant

Attributs du protein: AA 1-712

Origine: Humain

Source: Escherichia coli (E. coli)

Fonction: Recombinant Human Signal Transducer and Activator of Transcription 1/STAT1

Séquence: GSHMSQWYEL QQLDSKFLEQ VHQLYDDSFP MEIRQYLAQW LEKQDWEHAA NDVSFATIRF HDLLSQLDDQ YSRFSLENNF LLQHNIRKSK RNLQDNFQED PIQMSMIIYS CLKEERKILE NAQRFNQAQS GNIQSTVMLD KQKELDSKVR NVKDKVMCIE HEIKSLEDLQ DEYDFKCKTL QNREHETNGV AKSDQKQEQL LLKKMYLMLD NKRKEVVHKI IELLNVTELT QNALINDELV EWKRRQQSAC IGGPPNACLD QLQNWFTIVA ESLQQVRQQL KKLEELEQKY TYEHDPITKN KQVLWDRTFS LFQQLIQSSF VVERQPCMPT HPQRPLVLKT GVQFTVKLRL LVKLQELNYN LKVKVLFDKD VNERNTVKGF RKFNILGTHT KVMNMEESTN GSLAAEFRHL QLKEQKNAGT RTNEGPLIVT EELHSLSFET QLCQPGLVID LETTSLPVVV ISNVSQLPSG WASILWYNML VAEPRNLSFF LTPPCARWAQ LSEVLSWQFS SVTKRGLNVD QLNMLGEKLL GPNASPDGLI PWTRFCKENI NDKNFPFWLW IESILELIKK HLLPLWNDGC IMGFISKERE RALLKDQQPG TFLLRFSESS REGAITFTWV ERSQNGGEPD FHAVEPYTKK ELSAVTFPDI IRNYKVMAAE NIPENPLKYL YPNIDKDHAF GKYYSRPKEA PEPMELDGPK GTGYIKTELI SVSEV

Attributs du produit:

Recombinant Human Signal Transducer and Activator of Transcription 1/STAT1

Pureté: > 95 % as determined by reducing SDS-PAGE.

Stérilité: 0.2 μm filtered

niveau d'endotoxine: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl, pH 7.4.

Conseil sur la manipulation: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Stock: 4 °C/-20 °C/-80 °C

Stockage commentaire: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: STAT1 (Signal Transducer and Activator of Transcription 1, 91kDa (STAT1))

Autre désignation: Signal Transducer and Activator of Transcription 1-alpha/beta/stat1 (STAT1 Produits)

Synonymes: CANDF7 Protein, ISGF-3 Protein, STAT91 Protein, 2010005J02Rik Protein, AA408197 Protein, XStat1 Protein, STAT4 Protein, DD6G4-4 Protein, STAT Protein, STAT1 Protein, dZ182H3.3 Protein, si:by134g18.2 Protein, si:by51f19.1 Protein, si:dz182h3.3 Protein, si:dz199m19.1 Protein, si:dz73o4.2 Protein, stat1 Protein, signal transducer and activator of transcription 1 Protein, signal transducer and activator of transcription 1 L homeolog Protein, signal transducer and activator of transcription 1, 91kDa Protein, signal transducer and activator of transcription 4 Protein, signal transducer and activator of transcription 1a Protein, STAT1 Protein, Stat1 Protein, stat1.L Protein, stat4 Protein, stat1a Protein

Sujet: Recombinant Human Signal Transducer and Activator of Transcription 1-α/β/STAT1 is produced with our E. coli expression system. The target protein is expressed with sequence (Met1-Val712) of Human STAT1.
Signal Transducer and Activator of Transcription 1-α/β (STAT1) contains one SH2 domain and belongs to the transcription factor STAT family. When tyrosine- and serine-phosphorylated, STAT1 can form a homodimer termed IFN-γ-activated factor (GAF), migrate into the nucleus and bind to the IFN γ activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. STAT1 functions as signal transducer and transcription activator that mediates cellular responses to interferons. Defects in STAT1 are the cause of STAT1 deficiency complete and familial candidiasis type 7.

Poids moléculaire: 83.3 kDa

UniProt: P42224

Pathways: Signalistation JAK/STAT, Signalisation RTK, Interferon-gamma Pathway, Response to Growth Hormone Stimulus, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Endopeptidase Activity, Hepatitis C, CXCR4-mediated Signaling Events