P4HB Protein (AA 18-505) (His tag)

N° du produit ABIN1692113

Détail du produit

Antigène: P4HB (Prolyl 4-Hydroxylase, beta Polypeptide (P4HB))

Type de proteíne: Recombinant

Attributs du protein: AA 18-505

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette P4HB protéine est marqué à la His tag.

Fonction: Recombinant Human Prolyl 4-Hydroxylase Subunit β/P4HB/PDIA1 (C-6His)

Séquence: DAPEEEDHVL VLRKSNFAEA LAAHKYLLVE FYAPWCGHCK ALAPEYAKAA GKLKAEGSEI RLAKVDATEE SDLAQQYGVR GYPTIKFFRN GDTASPKEYT AGREADDIVN WLKKRTGPAA TTLPDGAAAE SLVESSEVAV IGFFKDVESD SAKQFLQAAE AIDDIPFGIT SNSDVFSKYQ LDKDGVVLFK KFDEGRNNFE GEVTKENLLD FIKHNQLPLV IEFTEQTAPK IFGGEIKTHI LLFLPKSVSD YDGKLSNFKT AAESFKGKIL FIFIDSDHTD NQRILEFFGL KKEECPAVRL ITLEEEMTKY KPESEELTAE RITEFCHRFL EGKIKPHLMS QELPEDWDKQ PVKVLVGKNF EDVAFDEKKN VFVEFYAPWC GHCKQLAPIW DKLGETYKDH ENIVIAKMDS TANEVEAVKV HSFPTLKFFP ASADRTVIDY NGERTLDGFK KFLESGGQDG AGDDDDLEDL EEAEEPDMEE DDDQKAVKVD HHHHHH

Attributs du produit:

Recombinant Human Prolyl 4-Hydroxylase Subunit β/P4HB/PDIA1 (C-6His)

Pureté: > 95 % as determined by reducing SDS-PAGE.

Stérilité: 0.2 μm filtered

niveau d'endotoxine: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Reconstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

Conseil sur la manipulation: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Stock: -80 °C

Stockage commentaire: Store at < -20°C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles.

Date de péremption: 6 months

Détail du antigène

Antigène: P4HB (Prolyl 4-Hydroxylase, beta Polypeptide (P4HB))

Autre désignation: Prolyl 4-Hydroxylase Subunit beta/p4hb (P4HB Produits)

Synonymes: DSI Protein, ERBA2L Protein, GIT Protein, P4Hbeta Protein, PDI Protein, PDIA1 Protein, PHDB Protein, PO4DB Protein, PO4HB Protein, PROHB Protein, PDA2 Protein, PDIP Protein, PDIR Protein, ERp59 Protein, Pdia1 Protein, Thbp Protein, p55 Protein, XPDIp Protein, pdi Protein, 1810041F13Rik Protein, AI661267 Protein, Pdip Protein, Pdipl Protein, p58 Protein, prolyl 4-hydroxylase subunit beta Protein, protein disulfide isomerase family A member 2 Protein, prolyl 4-hydroxylase, beta polypeptide Protein, protein disulfide isomerase family A member 2 L homeolog Protein, protein disulfide isomerase associated 2 Protein, prolyl 4-hydroxylase subunit beta L homeolog Protein, protein disulfide-isomerase Protein, P4HB Protein, PDIA2 Protein, P4hb Protein, pdia2.L Protein, Pdia2 Protein, p4hb.L Protein, LOC8281065 Protein

Sujet: Recombinant Human Prolyl 4-Hydroxylase Subunit β/P4HB is produced with our E. coli expression system. The target protein is expressed with sequence (Asp18-Lys505) of Human P4HB fused with a 6His tag at the C-terminus.
Protein Disulfide-Isomerase (P4HB) is an endoplasmic reticulum lumen protein that belongs to the protein disulfide isomerase family. P4HB contains two thioredoxin domains and catalyzes the formation, breakage, and rearrangement of -S-S- bonds in proteins. P4HB is involved in hydroxylation of prolyl residues in preprocollagen. P4HB has the ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner. P4HB plays a role in both the influx and efflux of S-nitrosothiol-bound nitric oxide.

Poids moléculaire: 55.9 kDa

UniProt: P07237

Pathways: Maintenance of Protein Location, Cell RedoxHomeostasis, Lipid Metabolism