ABCB5 Protein (AA 141-247) (TRX tag)

N° du produit ABIN1692397

Détail du produit

Antigène: ABCB5 (ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 5 (ABCB5))

Type de proteíne: Recombinant

Attributs du protein: AA 141-247

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette ABCB5 protéine est marqué à la TRX tag.

Fonction: Recombinant Human ATP-binding Cassette B5/ABCB5 (N-Trx)

Séquence: MSDKIIHLTD DSFDTDVLKA DGAILVDFWA EWCGPCKMIA PILDEIADEY QGKLTVAKLN IDQNPGTAPK YGIRGIPTLL LFKNGEVAAT KVGALSKGQL KEFLDANLAG SGSGHMHHHH HHSSGLVPRG SGMKETAAAK FERQHMDSPD LGTDDDDKAM AIRSADLIVT LKDGMLAEKG AHAELMAKRG LYYSLVMSQD IKKADEQMES MTYSTERKTN SLPLHSVKSI KSDFIDKAEE STQSKEISLP EVSLLKILKL NKPEWPFV

Attributs du produit: Recombinant Human ATP-binding cassette sub-family B member 5/ABCB5 is produced with our E. coli expression system. The target protein is expressed with sequence (Ile141-Val247) of Human ABCB5 fused with a Trx tag at the N-terminus.

Pureté: > 95 % as determined by reducing SDS-PAGE.

Stérilité: 0.2 μm filtered

niveau d'endotoxine: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl, pH 7.4.

Conseil sur la manipulation: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Stock: 4 °C/-20 °C/-80 °C

Stockage commentaire: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Date de péremption: 5 months

Détail du antigène

Antigène: ABCB5 (ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 5 (ABCB5))

Autre désignation: ABCB5 (ABCB5 Produits)

Synonymes: ABCB5alpha Protein, ABCB5beta Protein, EST422562 Protein, 9230106F14Rik Protein, RGD1566342 Protein, ABCB5 Protein, mdr1 Protein, im:7158730 Protein, wu:fc18f02 Protein, wu:fi81f06 Protein, ATP binding cassette subfamily B member 5 Protein, ATP-binding cassette, sub-family B (MDR/TAP), member 5 Protein, ATP-binding cassette sub-family B member 5 Protein, ABCB5 Protein, Abcb5 Protein, abcb5 Protein, TGME49_249820 Protein, PAAG_04387 Protein, VDBG_00160 Protein, VDBG_02292 Protein

Sub Type: Fusionprotein

Sujet: ATP-binding cassette sub-family B member 5(ABCB5) is a plasma membrane-spanning protein. ABCB5 is principally expressed in physiological skin and human malignant melanoma. ABCB5 has been suggested to regulate skin progenitor cell fusion and mediate chemotherapeutic drug resistance in stem-like tumor cell subpopulations in human malignant melanoma. It is commonly over-expressed on circulating melanoma tumour cells. Furthermore, the ABCB5+ melanoma- initiating cells were demonstrated to express FLT1 (VEGFR1) receptor tyrosine kinase which was functionally required for efficient xenograft tumor formation, as demonstrated by shRNA knockdown experiments.
Alternative Names: ATP-binding cassette sub-family B member 5, P-glycoprotein ABCB5, ABCB5 P-gp, ABCB5,

Poids moléculaire: 29.4 kDa

UniProt: Q2M3G0