GABARAP Protein (AA 1-116) (His tag,Fc Tag)

N° du produit ABIN1880607

Détail du produit

Antigène: GABARAP (GABA(A) Receptor-Associated Protein (GABARAP))

Type de proteíne: Recombinant

Attributs du protein: AA 1-116

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette GABARAP protéine est marqué à la His tag,Fc Tag.

Fonction: Recombinant Human GABA(A) Receptor-Associated Protein/GABARAP (N-6His, C-Fc)

Séquence: MGSSHHHHHH SSGLVPRGSH MKFVYKEEHP FEKRRSEGEK IRKKYPDRVP VIVEKAPKAR IGDLDKKKYL VPSDLTVGQF YFLIRKRIHL RAEDALFFFV NNVIPPTSAT MGQLYQEHHE EDFFLYIAYS DESVYGLVDD IEGRMDEPKS CDKTHTCPPC PAPELLGGPS VFLFPPKPKD TLMISRTPEV TCVVVDVSHE DPEVKFNWYV DGVEVHNAKT KPREEQYNST YRVVSVLTVL HQDWLNGKEY KCKVSNKALP APIEKTISKA KGQPREPQVY TLPPSREEMT KNQVSLTCLV KGFYPSDIAV EWESNGQPEN NYKTTPPVLD SDGSFFLYSK LTVDKSRWQQ GNVFSCSVMH EALHNHYTQK SLSLSPGK

Attributs du produit: Recombinant Recombinant Human GABA(A) receptor-associated protein/GABARAP is produced with our E. coli expression system. The target protein is expressed with sequence (Met1-Gln116) of Human GABARAP fused with a polyhistidine tag at the N-terminus.

Pureté: > 95 % as determined by reducing SDS-PAGE.

Stérilité: 0.2 μm filtered

niveau d'endotoxine: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Reconstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl,20 % glycerol, pH 7.0.

Conseil sur la manipulation: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Stock: -80 °C

Stockage commentaire: Store at < -20°C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles.

Date de péremption: 6 months

Détail du antigène

Antigène: GABARAP (GABA(A) Receptor-Associated Protein (GABARAP))

Autre désignation: GABA(A) Receptor-Associated Protein/GABARAP (GABARAP Produits)

Synonymes: GABARAP Protein, ATG8A Protein, GABARAP-a Protein, MM46 Protein, gabarap Protein, mg:bb02b03 Protein, GABA type A receptor-associated protein Protein, gamma-aminobutyric acid receptor-associated protein Protein, GABA(A) receptor-associated protein a Protein, gamma-aminobutyric acid receptor associated protein Protein, GABARAP Protein, LOC5568843 Protein, Gabarap Protein, gabarapa Protein

Sujet: Gamma-Aminobutyric Acid Receptor-Associated Protein (GABARAP) is a ligand-gated chloride channel protein that mediates inhibitory neurotransmission and belongs to the MAP1 LC3 family. GABARAP is highly positively charged in its N-terminus and shares sequence similarity with light chain-3 of microtubule-associated proteins 1A and 1B. GABARAP clusters neurotransmitter receptors by mediating interaction with the cytoskeleton. Autophagy is the process by which cells recycle cytoplasm and dispose of excess or defective organelles. This process is suggested to be involved development, differentiation, growth regulation and tissue remodeling in multicellular organisms. An important inhibitory neurotransmitter, GABA, acts on GABA receptors that are ubiquitously expressed in the CNS. GABARAP has been shown to play a important role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton.

Poids moléculaire: 43.2 kDa

UniProt: Q6IAW1

Pathways: Autophagy