Mitogen-Activated Protein Kinase 1 (MAPK1) (AA 1-360) protein (GST tag)

Détails pour le produit réf. ABIN2001936, Fournisseur: Connectez-vous pour afficher
Nom de la protéine
  • ERK
  • ERK2
  • ERT1
  • MAPK2
  • P42MAPK
  • PRKM1
  • PRKM2
  • p38
  • p40
  • p41
  • p41mapk
  • 9030612K14Rik
  • AA407128
  • AU018647
  • C78273
  • Erk2
  • Prkm1
  • p42mapk
  • zERK2
  • MAPK1
  • Xp42
  • erk
  • erk2
  • ert1
  • mapk
  • mapk1b
  • mapk2
  • mpk1
  • prkm1
  • prkm2
  • mapk1
  • mapk1a
  • xp42
  • ATMPK1
  • F14N23.9
  • F14N23_9
  • MITOGEN-ACTIVATED PROTEIN KINASE
  • mitogen-activated protein kinase 1
  • mitogen-activated protein kinase 1
  • mitogen activated protein kinase 1
  • mitogen-activated protein kinase 1 L homeolog
  • mitogen-activated protein kinase 1 S homeolog
  • MAPK1
  • Mapk1
  • mapk1
  • mapk1.L
  • mapk1.S
  • PfMAP1
  • MPK1
  • PVX_084965
  • LOC9328617
  • Tsp_01601
Attributs du protein
AA 1-360
7
6
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Origine
Humain
25
6
5
2
2
1
1
Source
Baculovirus infected Insect Cells
13
7
4
3
2
2
2
Type de proteíne
Recombinant
Purification/Conjugué
Cette ERK2 protéine est marqué à la GST tag.
Application
SDS-PAGE (SDS)
Options
Fournisseur
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N° du produit (Fournisseur)
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Attributs du produit The recombinant human ERK2/GST chimera consists of 585 amino acids and predicts a molecular mass of 67 kDa as estimated in SDS-PAGE under reducing conditions.

Protein Structure: A DNA sequence encoding the human ERK2 (NP_002736.3) (Met 1-Ser 360) was fused with the GST tag at the N-terminus.
Predicted N-Term: Met
Pureté > 98 % as determined by SDS-PAGE
niveau d'endotoxine < 1.0 EU per μg of the protein as determined by the LAL method
Biological Activity Comment No Kinase Activity
Nom de la protéine
Sujet Synonyms: ERK,ERK-2,ERK2,ERT1,MAPK2,p38,p40,p41,p41mapk,p42-MAPK,P42MAPK,PRKM1,PRKM2
Poids moléculaire 67 kDa
NCBI Accession NP_002736
Pathways Signalisation MAPK, Signalisation RTK, Apoptose, Interferon-gamma Pathway, Fc-epsilon Receptor Signaling Pathway, Response to Growth Hormone Stimulus, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Protein targeting to Nucleus, Toll-Like Receptors Cascades, Monocarboxylic Acid Catabolic Process, Autophagy, G-protein mediated Events, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, VEGFR1 Specific Signals
Indications d'application Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Lyophilized
Buffer Lyophilized from sterile 50 mM Tris, 100 mM NaCl, 0.5 mM PMSF, 10 % Glycerol, pH 8.0
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.
Conseil sur la manipulation Avoid repeated freeze-thaw cycles. It is recommended that the protein be aliquoted for optimal storage.
Stock -20 °C,-80 °C
Stockage commentaire Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

Shipping: In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Date de péremption 12 months
Images (Fournisseur)
SDS-PAGE (SDS) image for Mitogen-Activated Protein Kinase 1 (MAPK1) (AA 1-360) protein (GST tag) (ABIN2001936) Mitogen-Activated Protein Kinase 1 (MAPK1) (AA 1-360) protein (GST tag)
Produit citée dans: Jahrling, Hernandez, Denner, Dineley: "PPAR? recruitment to active ERK during memory consolidation is required for Alzheimer's disease-related cognitive enhancement." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 34, Issue 11, pp. 4054-63, 2014 (PubMed).

Background publications Slack, Seternes, Gabrielsen, Keyse: "Distinct binding determinants for ERK2/p38alpha and JNK map kinases mediate catalytic activation and substrate selectivity of map kinase phosphatase-1." dans: The Journal of biological chemistry, Vol. 276, Issue 19, pp. 16491-500, 2001

Slack, Seternes, Gabrielsen, Keyse: "Distinct binding determinants for ERK2/p38alpha and JNK map kinases mediate catalytic activation and substrate selectivity of map kinase phosphatase-1." dans: The Journal of biological chemistry, Vol. 276, Issue 19, pp. 16491-500, 2001 (PubMed).

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