IL12 Protein (AA 23-215, AA 23-335) (His tag)
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- Antigène Voir toutes IL12 Protéines
- IL12 (Interleukin 12 (IL12))
- Type de proteíne
- Recombinant
- Activité biologique
- Active
- Attributs du protein
- AA 23-215, AA 23-335
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Origine
- Rat
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Source
- CHO Cells
- Purification/Conjugué
- Cette IL12 protéine est marqué à la His tag.
- Attributs du produit
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ED50< 0.1 ng/mL, measured in a cell proliferation assay using 2D6 cells.
AA 23-215 (p35) and AA 23-335 (p40), expressed with C-terminal 6×His. - Pureté
- > 95 % as analyzed by SDS-PAGE.
- niveau d'endotoxine
- < 0.2 EU/μg, determined by LAL method.
- Top Product
- Discover our top product IL12 Protéine
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Reconstituted in ddH2O or PBS at 100 μg/mL.
- Buffer
- Lyophilized after extensive dialysis against PBS.
- Stock
- -80 °C
- Stockage commentaire
- Lyophilized recombinant rat Interleukin-12 (IL-12), His remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, rat Interleukin-12 (IL-12), His should be stable up to 1 week at 4°C or up to 2 months at -20°C.
- Date de péremption
- 6 months
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- Antigène
- IL12 (Interleukin 12 (IL12))
- Autre désignation
- Interleukin-12 (IL-12) (IL12 Produits)
- Synonymes
- CLMF Protein, CLMF2 Protein, IL-12B Protein, NKSF Protein, NKSF2 Protein, p40 Protein, Il-12b Protein, Il12p40 Protein, Il-12p40 Protein, Il12 Protein, IL-12p40 Protein, IL-12 Protein, LOC100217488 Protein, IL-12p35 Protein, Il-12a Protein, Ll12a Protein, p35 Protein, IL12p40 Protein, IL12B Protein, IL-12 p35 Protein, interleukin 12B Protein, interleukin 12A Protein, interleukin 12b Protein, interleukin 12a Protein, Interleukin 12 level Protein, IL12B Protein, IL12A Protein, Il12b Protein, Il12a Protein, IL12 Protein, il12a Protein
- Sujet
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Interleukin-12 (IL-12), also known as NKSF, TCMF, CLMF and TSF, is a heterodimeric cytokine composed of p35 and p40 subunits. It is produced by monocytes, macrophages, B cells and dendritic cells in response to bacterial lipopolysaccharides and intracellular pathogens. IL-12 signals through the IL-12 receptor complex, which is comprised of IL-12 Rβ1 and IL-12 Rβ2. IL-12 induces the proliferation and activation of hematopoietic stem cells, natural killer cells and T- cells. It is indispensible during the development of Th1 cells, leading to the production of IFN-gamma and IL-2.
Synonyms: NKSF, TCMF, CLMF, TSF - Poids moléculaire
- 26-28kDa (p35) and 42-45 kDa (p40), observed by reducing SDS-PAGE.
- NCBI Accession
- NP_072133
- UniProt
- Q9R103
- Pathways
- Signalistation JAK/STAT, Signalisation TLR, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation, Cancer Immune Checkpoints, Inflammasome
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