FGF7 Protein (AA 32-194) (His tag)
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- Antigène Voir toutes FGF7 Protéines
- FGF7 (Fibroblast Growth Factor 7 (FGF7))
- Type de proteíne
- Recombinant
- Activité biologique
- Active
- Attributs du protein
- AA 32-194
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Origine
- Humain
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Source
- Escherichia coli (E. coli)
- Purification/Conjugué
- Cette FGF7 protéine est marqué à la His tag.
- Attributs du produit
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ED50 < 10 ng/mL, measured by a cell proliferation assay using 4MBr-5 cells, corresponding to a specific activity of > 1.0x 10^5 units/mg.
AA 32 -194, expressed with N-terminal His-Tag. - Pureté
- > 95 % by SDS-PAGE and HPLC analyses.
- niveau d'endotoxine
- < 0.2 EU/μg, determined by LAL method.
- Top Product
- Discover our top product FGF7 Protéine
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Reconstituted in ddH2O at 100 μg/mL.
- Buffer
- Lyophilized after extensive dialysis against PBS.
- Stock
- -80 °C
- Stockage commentaire
- Lyophilized recombinant human Keratinocyte Growth Factor (rhKGF) remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, rhKGF should be stable up to 2 weeks at 4 °C or up to 3 months at -20 °C.
- Date de péremption
- 6 months
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- Antigène
- FGF7 (Fibroblast Growth Factor 7 (FGF7))
- Autre désignation
- Keratinocyte Growth Factor (KGF/FGF-7) (FGF7 Produits)
- Synonymes
- HBGF-7 Protein, KGF Protein, Kgf Protein, kgf Protein, FGF-7 Protein, fgf7 Protein, fibroblast growth factor 7 Protein, fibroblast growth factor 7 L homeolog Protein, FGF7 Protein, Fgf7 Protein, fgf7 Protein, fgf7.L Protein
- Sujet
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Keratinocyte Growth Factor (KGF) is a highly specific epithelial mitogen produced by fibroblasts and mesenchymal stem cells. KGF belongs to the heparin binding Fibroblast Growth Factor (FGF) family, and is known as FGF-7. However, in contrast to the FGF-1, which binds to all known FGF receptors with high affinity, KGF only binds to a splice variant of an FGF receptor, FGFR2-IIIb. FGFR2-IIIb is produced by most of the epithelial cells, indicating that KGF plays roles as a paracrine mediator. KGF induces the differen-tiation and proliferation of various epithelial cells, including keratinocytes in the epidermis, hair follicles and sebaceous glands, and is responsible for the wound repairs of various tissues, including lung, bladder, and kidney. Recombinant human Keratinocyte Growth Factor (rhKGF) with N-terminal His-tag produced in E. coli is a single non-glycosylated polypeptide chain containing 181 amino acids. A fully biologically active molecule, rhKGF has a molecular mass of 21.2 kDa analyzed by reducing SDS-PAGE.
Synonyms: Keratinocyte Growth Factor, Fibroblast Growth Factor-7, HBGF-7 - Poids moléculaire
- 21.2 kDa, observed by reducing SDS-PAGE.
- UniProt
- P21781
- Pathways
- Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
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