CCL15 Protein (AA 22-113, Ile24Thr-Mutant)

N° du produit ABIN2018259

Détail du produit

Antigène: CCL15 (Chemokine (C-C Motif) Ligand 15 (CCL15))

Type de proteíne: Recombinant

Activité biologique: Active

Attributs du protein: AA 22-113, Ile24Thr-Mutant

Origine: Humain

Source: Escherichia coli (E. coli)

Attributs du produit: ED50 < 2 μg/mL, measured by the FLIPR assay using CHO cells transfected with human CCR1, the receptor of human CCL15, corresponding to a specific activity of > 500 units/mg.

Pureté: > 95 % by SDS-PAGE analysis.

niveau d'endotoxine: < 0.2 EU/μg, determined by LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Reconstituted in ddH2O at 100 μg/mL.

Buffer: Lyophilized after extensive dialysis against PBS.

Stock: -80 °C

Stockage commentaire: Lyophilized recombinant human MIP-5/CCL15 (rhMIP-5/CCL15) remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, rhMIP-5/CCL15 remains stable up to 2 weeks at 4 °C or up to 3 months at -20 °C.

Date de péremption: 6 months

Détail du antigène

Antigène: CCL15 (Chemokine (C-C Motif) Ligand 15 (CCL15))

Autre désignation: MIP-5 /CCL15 (CCL15 Produits)

Synonymes: HCC-2 Protein, HMRP-2B Protein, LKN-1 Protein, LKN1 Protein, MIP-1 delta Protein, MIP-1D Protein, MIP-5 Protein, MRP-2B Protein, NCC-3 Protein, NCC3 Protein, SCYA15 Protein, SCYL3 Protein, SY15 Protein, C-C motif chemokine ligand 15 Protein, CCL15 Protein

Sujet: Macrophage Inflammatory Protein-5 (MIP-5/CCL15) is a chemokine originally identified in the human hemofiltrate, thus it is also named Hemofiltrate CC Chemokine-2 (HCC-2). MIP-5 belongs to the CCL chemokine family, and its receptors are G-protein coupled receptors CCR1 and CCR3, with CCR1 being the major one. MIP-5 is mainly expressed in heart and skeletal muscle, and CCR1 is expressed on Th1 and Th2 cells in human cord blood lymphocytes. In vivo, MIP-5 promotes the accumulation of immature myeloid cells and the expansion of metastatic foci in the lever. MIP-5 contributes to severe asthma, sarcoidosis, and atherosclerosis,however, MIP-5 can also inhibit stem cell proliferation, implicating its therapeutic potential as an alternative to high dose chemotherapy.Recombinant human MIP-5/CCL15 (rhMIP-5/CCL15) produced in E.coli is a single non-glycosylated polypeptide chain containing 92 amino acids. A fully biologically active molecule, rhMIP-5/CCL15 has a molecular mass of 10.2 kDa analyzed by reducing SDS-PAGE.
Synonyms: HCC-2, LKN-1, MIP-1 delta

Poids moléculaire: 10.2 kDa, observed by reducing SDS-PAGE.

UniProt: Q16663