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PDGF-BB Homodimer (Active) Protéine

Origine: Humain Hôte: Escherichia coli (E. coli) Recombinant > 97 % by SDS-PAGE and HPLC analyses. Active
N° du produit ABIN2018319
  • Antigène
    PDGF-BB Homodimer
    Type de proteíne
    Recombinant
    Activité biologique
    Active
    Origine
    • 10
    • 5
    • 3
    Humain
    Source
    • 13
    • 2
    • 1
    • 1
    Escherichia coli (E. coli)
    Séquence
    MSLGSLTIAE PAMIAECKTR TEVFEISRRL IDRTNANFLV WPPCVEVQRC SGCCNNRNVQ CRPTQVQLRP VQVRKIEIVR KKPIFKKATV TLEDHLACKC ETVAAARPVT
    Attributs du produit
    Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine Balb/c 3T3 cells is less than 3 ng/mL, corresponding to a specific activity of > 3.3 x 10^5 IU/mg.
    Pureté
    > 97 % by SDS-PAGE and HPLC analyses.
    Stérilité
    0.2 μm filtered
    niveau d'endotoxine
    < 1 EU/μg of rHuPDGF-BB as determined by LAL method.
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
    Buffer
    Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4.
    Conseil sur la manipulation
    Avoid repeated freeze/thaw cycles.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    This lyophilized preparation is stable at 2-8 °C, but should be kept at -20 °C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 °C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 °C to -70 °C.
  • Antigène
    PDGF-BB Homodimer
    Autre désignation
    Platelet-Derived Growth Factor-BB
    Synonymes
    PDGF-2 Protein, PDGF2 Protein, SIS Protein, SSV Protein, c-sis Protein, PDGF-B Protein, Sis Protein, platelet derived growth factor subunit B Protein, platelet derived growth factor, B polypeptide Protein, PDGFB Protein, Pdgfb Protein
    Sujet
    Platelet-derived growth factor (PDGF) presenting in serum but absent from plasma was first discovered in animal study by Lynch and co-workers in the late 1980s. It is a disulfide-linked dimer consisting of two peptides-chain A and chain B. PDGF has three subforms: PDGF-AA, PDGF-BB, PDGF-AB. It is involved in a number of biological processes, including hyperplasia, embryonic neuron development, chemotaxis, and respiratory tubule epithelial cell development. The function of PDGF is mediated by two receptors (PDGFR-alpha and PDGFR-beta).
    Synonyms: PDGF-BB human, rHuPDGF-BB
    Poids moléculaire
    24.8 kDa, a disulfide-linked homodimeric protein containing two 110 amino acid residues polypeptide (B chain).
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