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BCMA Protein (AA 1-54) (Fc Tag)

TNFRSF17 Origine: Humain Hôte: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
N° du produit ABIN2180644
  • Antigène Voir toutes BCMA (TNFRSF17) Protéines
    BCMA (TNFRSF17) (Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17))
    Type de proteíne
    Recombinant
    Activité biologique
    Active
    Attributs du protein
    AA 1-54
    Origine
    • 42
    • 13
    • 6
    • 6
    • 2
    • 1
    • 1
    Humain
    Source
    • 42
    • 8
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    HEK-293 Cells
    Purification/Conjugué
    Cette BCMA protéine est marqué à la Fc Tag.
    Séquence
    AA 1-54
    Attributs du produit
    This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 32 kDa. As a result of glycosylation, the protein migrates as 35-40 kDa under reducing (R) condition, and 66 kDa under non-reducing (NR) condition (SDS-PAGE).
    Pureté
    >95 % as determined by SDS-PAGE.
    Stérilité
    0.22 μm filtered
    niveau d'endotoxine
    Less than 0.1 EU per μg by the LAL method.
    Top Product
    Discover our top product TNFRSF17 Protéine
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Buffer
    PBS, pH 7.4
    Conseil sur la manipulation
    Please avoid repeated freeze-thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
  • Berahovich, Liu, Zhou, Tsadik, Xu, Golubovskaya, Wu: "Hypoxia Selectively Impairs CAR-T Cells In Vitro." dans: Cancers, Vol. 11, Issue 5, (2019) (PubMed).

    Berahovich, Zhou, Xu, Wei, Guan, Guan, Harto, Fu, Yang, Zhu, Li, Wu, Golubovskaya: "CAR-T Cells Based on Novel BCMA Monoclonal Antibody Block Multiple Myeloma Cell Growth." dans: Cancers, Vol. 10, Issue 9, (2018) (PubMed).

  • Antigène
    BCMA (TNFRSF17) (Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17))
    Autre désignation
    BCMA (TNFRSF17 Produits)
    Synonymes
    TNFRSF17 Protein, BCM Protein, BCMA Protein, CD269 Protein, TNFRSF13A Protein, Tnfrsf13 Protein, Tnfrsf13a Protein, TNF receptor superfamily member 17 Protein, tumor necrosis factor receptor superfamily, member 17 Protein, Tnfrsf17 Protein, TNFRSF17 Protein
    Sujet
    Tumor necrosis factor receptor superfamily member 17 (TNFRSF17) is also known as B-cell maturation protein (BCMA), CD antigen CD269, which is a member of the TNF-receptor superfamily. TNFRSF17 contains one TNFR-Cys repeat. TNFRSF17 is expressed in mature B-cells, but not in T-cells or monocytes. TNFRSF17 is receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. TNFRSF17 promotes B-cell survival and plays a role in the regulation of humoral immunity. TNFRSF17 can activate NF-kappa-B and JNK.
    Poids moléculaire
    32.0 kDa
    NCBI Accession
    NP_001183
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