CD38 Protein (AA 43-300) (His tag)

N° du produit ABIN2180767

Détail du produit

Antigène: CD38

Type de proteíne: Recombinant

Activité biologique: Active

Attributs du protein: AA 43-300

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette CD38 protéine est marqué à la His tag.

Séquence: AA 43-300

Attributs du produit: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 30.7 kDa. The protein migrates as 30-45 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Pureté: >95 % as determined by SDS-PAGE.

Stérilité: 0.22 μm filtered

niveau d'endotoxine: Less than 1.0 EU per μg by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 50 mM MES, 100 mM NaCl, pH 6.5

Conseil sur la manipulation: Please avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C-8 °C), After reconstitution under sterile conditions for 1 month (4 °C-8 °C) or 3 months (-20 °C to -70 °C).

Référence

Wang, Chen, Hou, Liu, Zhang, Zhao, Zhang, An, Li, Hou, Huang, Liu, Zhao, Wei: "ImmunoPET imaging of multiple myeloma with [68Ga]Ga-NOTA-Nb1053." dans: European journal of nuclear medicine and molecular imaging, Vol. 48, Issue 9, pp. 2749-2760, (2021) (PubMed).

Détail du antigène

Antigène: CD38

Abstract: CD38 Produits

Synonymes: T10 Protein, Cd38-rs1 Protein, cd38 Protein, ADPRC 1 Protein, cADPr hydrolase 1 Protein, CD38 molecule Protein, CD38 antigen Protein, CD38 molecule L homeolog Protein, ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Protein, CD38 Protein, Cd38 Protein, cd38.L Protein

Sujet: CD antigen CD38 is also known as ADP-ribosyl cyclase 1, which belongs to the ADP-ribosyl cyclase family. CD38 is expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma. CD38 is a multifunctional ectoenzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD+ to ADP-ribose. These reaction products are essential for the regulation of intracellular Ca2+. The loss of CD38 function is associated with impaired immune responses, metabolic disturbances, and behavioral modifications. The CD38 protein is a marker of cell activation. It has been connected to HIV infection, leukemias, myelomas, solid tumors, type II diabetes mellitus and bone metabolism. CD38 has been used as a prognostic marker in leukemia.

Poids moléculaire: 30.7 kDa

NCBI Accession: NP_001766