CD47 Protein (CD47) (AA 19-139) (Fc Tag)

N° du produit ABIN2180805

Détail du produit

Antigène: CD47

Type de proteíne: Recombinant

Activité biologique: Active

Attributs du protein: AA 19-139

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette CD47 protéine est marqué à la Fc Tag.

Séquence: AA 19-139

Attributs du produit: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 40.4 kDa. The protein migrates as 50-65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Pureté: >95 % as determined by SDS-PAGE.

Stérilité: 0.22 μm filtered

niveau d'endotoxine: Less than 1.0 EU per μg by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 50 mM Tris, 100 mM Glycine, pH 7.5

Conseil sur la manipulation: Please avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).

Référence

Yu, Qiu, Long, Yang, Zhang, Xu, Chang, Du, Hou, Yu, Zeng, Wang, Sun: "A novel fully human anti-CD47 antibody as a potential therapy for human neoplasms with good safety." dans: Biochimie, Vol. 151, pp. 54-66, (2018) (PubMed).

Détail du antigène

Antigène: CD47

Autre désignation: CD47 (CD47 Produits)

Synonymes: IAP Protein, MER6 Protein, OA3 Protein, 9130415E20Rik Protein, AA407862 Protein, AI848868 Protein, AW108519 Protein, B430305P08Rik Protein, Itgp Protein, CD47/IAP Protein, alkaline phosphatase, intestinal Protein, CD47 molecule Protein, CD47 antigen (Rh-related antigen, integrin-associated signal transducer) Protein, Cd47 molecule Protein, ALPI Protein, CD47 Protein, Cd47 Protein

Sujet: Leukocyte surface antigen CD47 is also known as Antigenic surface determinant protein OA3, Integrin-associated protein (IAP) and Protein MER6. CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain. CD47 is very broadly distributed on normal adult tissues. CD47 has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins and plays an important role in memory formation and synaptic plasticity in the hippocampus by similarity. CD47 is the receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. CD47 Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation.

Poids moléculaire: 40.4 kDa

NCBI Accession: NP_942088