NCR3 Protein (AA 19-135) (Fc Tag)
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- Antigène Voir toutes NCR3 Protéines
- NCR3 (Natural Cytotoxicity Triggering Receptor 3 (NCR3))
- Type de proteíne
- Recombinant
- Attributs du protein
- AA 19-135
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Origine
- Humain
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Source
- HEK-293 Cells
- Purification/Conjugué
- Cette NCR3 protéine est marqué à la Fc Tag.
- Séquence
- AA 19-135
- Attributs du produit
- This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 39.5 kDa. As a result of glycosylation, the protein migrates as 45-55 kDa under reducing (R) condition, and 90-110 kDa under non-reducing (NR) condition (SDS-PAGE).
- Pureté
- >95 % as determined by SDS-PAGE.
- Stérilité
- 0.22 μm filtered
- niveau d'endotoxine
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product NCR3 Protéine
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- 50 mM Tris, 100 mM Glycine, 150 mM NaCl, pH 7.5
- Conseil sur la manipulation
- Please avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
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- Antigène
- NCR3 (Natural Cytotoxicity Triggering Receptor 3 (NCR3))
- Autre désignation
- NKp30 (NCR3 Produits)
- Synonymes
- MGC133750 Protein, 1C7 Protein, CD337 Protein, LY117 Protein, MALS Protein, NKp30 Protein, Nkp30 Protein, natural cytotoxicity triggering receptor 3 Protein, NCR3 Protein, Ncr3 Protein
- Sujet
- Natural cytotoxicity triggering receptor 3 (NCR3) is also known as Activating natural killer receptor p30, Natural killer cell p30-related protein (NK-p30), CD antigen CD337, 1C7, LY117. NCR3 /CD337 /NKp30 belongs to the natural cytotoxicity receptor (NCR) family. NCR3 /NKp30 contains one Ig-like (immunoglobulin-like) domain. NCR3 /NKp30 is selectively expressed by all resting and activated NK cells and weakly expressed in spleen. NCR3 is homodimer in the unliganted form. NCR3 interacts with CD3Z. NCR3 interacts with and is activated by binding to NCR3LG1 or BAG6. Engagement of NCR3 by BAG6 also promotes dendritic cell (DC) maturation, both through killing those DCs that did not properly acquire a mature phenotype, and inducing NK cells to release TNFA and IFNG, which promotes DC maturation.
- Poids moléculaire
- 39.5 kDa
- Pathways
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
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