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Oncostatin M Protein (OSM) (AA 26-252)

OSM Origine: Humain Hôte: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE.
N° du produit ABIN2181568
  • Antigène Voir toutes Oncostatin M (OSM) Protéines
    Oncostatin M (OSM)
    Type de proteíne
    Recombinant
    Attributs du protein
    AA 26-252
    Origine
    • 25
    • 7
    • 4
    • 3
    • 1
    • 1
    Humain
    Source
    • 22
    • 12
    • 1
    • 1
    • 1
    • 1
    • 1
    HEK-293 Cells
    Marque
    ActiveMax®
    Séquence
    AA 26-252
    Attributs du produit
    This protein carries no "tag". The protein has a calculated MW of 25.8 kDa. The protein migrates as 36 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
    Pureté
    >95 % as determined by SDS-PAGE.
    Stérilité
    0.22 μm filtered
    niveau d'endotoxine
    Less than 1.0 EU per μg by the LAL method.
    Top Product
    Discover our top product OSM Protéine
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Buffer
    PBS, pH 7.4
    Conseil sur la manipulation
    Please avoid repeated freeze-thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C-8 °C), After reconstitution under sterile conditions for 1 month (4 °C-8 °C) or 3 months (-20 °C to -70 °C).
  • Antigène
    Oncostatin M (OSM)
    Autre désignation
    Oncostatin M (OSM Produits)
    Synonymes
    OSM Protein, OncoM Protein, oncostatin M Protein, OSM Protein, Osm Protein
    Sujet
    Oncostatin M is also known as OSM, is a glycoprotein belonging to the interleukin-6 family of cytokines that has functions mainly in cell growth. Of these cytokines it most closely resembles leukemia inhibitory factor (LIF) in both structure and function. However, it is as yet poorly defined and is proving important in liver development, haematopoeisis, inflammation and possibly CNS development. It is also associated with bone formation and destruction. OSM signals through cell surface receptors that contain the protein gp130. The type I receptor is composed of gp130 and LIFR, the type II receptor is composed of gp130 and OSMR. Oncostatin M (OSM) was previoustly identified by its ability to inhibit the growth of cells from melanoma and other solid tumors. It also has been reported that OSM, like LIF, IL-6 and G-CSF, has the ability to inhibit the proliferation of murine M1 myeloid leukemic cells and can induce their differentiation into macrophage-like cells. The human form of OSM is insensitive between pH 2 and 11 and resistant to heating for one hour at 56 degree but is not stable at 90 degrees. The three dimensional structure of human OSM has been solved to atomic resolution, confirming the predicted long chain four helix bundle topology. Comparing this structure with the known structures of other known LC cytokines shows it to be most closely related to LIF.
    Poids moléculaire
    25.8 kDa
    NCBI Accession
    NP_065391
    Pathways
    Signalistation JAK/STAT, Negative Regulation of Hormone Secretion
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