PDCD1LG2 Protein (AA 20-219) (His tag)

N° du produit ABIN2181599

Détail du produit

Antigène: PDCD1LG2 (Programmed Cell Death 1 Ligand 2 (PDCD1LG2))

Type de proteíne: Recombinant

Activité biologique: Active

Attributs du protein: AA 20-219

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette PDCD1LG2 protéine est marqué à la His tag.

Séquence: AA 20-219

Attributs du produit: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 23.4 kDa. The protein migrates as 35-48 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Pureté: >95 % as determined by SDS-PAGE.

Stérilité: 0.22 μm filtered

niveau d'endotoxine: Less than 1.0 EU per μg by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: PBS, pH 7.4

Conseil sur la manipulation: Please avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).

Référence

Fromm, de Silva, Johannes, Patel, Hornblower, Schreiber: "Agonist redirected checkpoint, PD1-Fc-OX40L, for cancer immunotherapy." dans: Journal for immunotherapy of cancer, Vol. 6, Issue 1, pp. 149, (2018) (PubMed).

Détail du antigène

Antigène: PDCD1LG2 (Programmed Cell Death 1 Ligand 2 (PDCD1LG2))

Autre désignation: PD-L2 (PDCD1LG2 Produits)

Sujet: Programmed cell death 1 ligand 2 (PD-L2 or PDCD1 ligand 2) is also known as Butyrophilin B7-DC, CD antigen CD273, which belongs to the immunoglobulin superfamily or BTN/MOG family. The expression of PD-L2 is up-regulated by IFNG/IFN-gamma stimulation in monocytes and induced on dendritic cells grown from peripheral blood mononuclear cells with CSF2 and IL-4. PD-L2 Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. PD-L2 interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.

Poids moléculaire: 23.4 kDa